PRKAB2 and PRKAG2

Number of citations of the paper that reports this interaction (PMID 10698692)
99

Data Source:
HPRD (two hybrid)

		PRKAB2	PRKAG2
Gene Name		protein kinase, AMP-activated, beta 2 non-catalytic subunit	protein kinase, AMP-activated, gamma 2 non-catalytic subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol AMP-activated Protein Kinase Complex	Extracellular Space Nucleoplasm Cytosol AMP-activated Protein Kinase Complex
	Molecular Function	AMP-activated Protein Kinase Activity Protein Binding Identical Protein Binding	AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Inhibitor Activity ATP Binding CAMP-dependent Protein Kinase Regulator Activity Phosphorylase Kinase Regulator Activity AMP Binding Protein Kinase Binding Protein Kinase Activator Activity ADP Binding
	Biological Process	Energy Reserve Metabolic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Carnitine Shuttle Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Regulation Of Protein Kinase Activity Membrane Organization	Glycogen Metabolic Process Regulation Of Glycolytic Process Energy Reserve Metabolic Process Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Fatty Acid Biosynthetic Process ATP Biosynthetic Process Carnitine Shuttle Organelle Organization Mitochondrion Organization Cell Cycle Arrest Insulin Receptor Signaling Pathway Positive Regulation Of Peptidyl-threonine Phosphorylation Sterol Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Intracellular Signal Transduction Regulation Of Fatty Acid Biosynthetic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Regulation Of Fatty Acid Oxidation Regulation Of Glucose Import Membrane Organization Negative Regulation Of Protein Serine/threonine Kinase Activity
Pathways		Organelle biogenesis and maintenance Integration of energy metabolism Metabolism of lipids and lipoproteins Regulation of Rheb GTPase activity by AMPK IRS-mediated signalling mTOR signalling Translocation of GLUT4 to the plasma membrane Import of palmitoyl-CoA into the mitochondrial matrix mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Fatty acid, triacylglycerol, and ketone body metabolism Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Mitochondrial biogenesis IRS-mediated signalling Activation of PPARGC1A (PGC-1alpha) by phosphorylation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade	Organelle biogenesis and maintenance Integration of energy metabolism Metabolism of lipids and lipoproteins Regulation of Rheb GTPase activity by AMPK IRS-mediated signalling mTOR signalling Translocation of GLUT4 to the plasma membrane Import of palmitoyl-CoA into the mitochondrial matrix mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Fatty acid, triacylglycerol, and ketone body metabolism Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Mitochondrial biogenesis IRS-mediated signalling Activation of PPARGC1A (PGC-1alpha) by phosphorylation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade
Drugs		Adenosine monophosphate
Diseases
GWAS			Bipolar disorder (age of onset and psychomotor symptoms) ( 21305692) Chronic kidney disease ( 20383146) Hematocrit ( 19862010) Hemoglobin ( 19862010) Red blood cell traits ( 23222517) Urate levels ( 23263486)
Protein-Protein Interactions		70 interactors: ADAMTSL4 BANP BEND5 BLZF1 CALCOCO2 CASP6 CCDC33 CCDC36 CDX4 CREB3L1 CRX CSNK2B DAO DDIT4L DICER1 DST EPM2A FAM208B FDX1 FLNC GATA1 GATAD2B GET4 GNB2L1 GOLGA2 GRN IKZF1 IKZF3 KCTD5 KLF15 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-4 LZTS2 MAGED1 MDFI MEOX2 NEBL PIAS2 PRDM14 PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 PSME3 PYGM RBPMS REL RHEBL1 RIMBP3 SPRY2 STX11 STX19 TADA2A TCF4 TP53BP2 TRAF2 TRIM10 UBXN11 YY1AP1 ZBTB32	3 interactors: PRKAB1 PRKAB2 PRKAG1
Entrez ID		5565	51422
HPRD ID		04117	04119
Ensembl ID		ENSG00000131791	ENSG00000106617
Uniprot IDs		O43741	G8JLM0 Q9UGJ0
PDB IDs		2F15 2V8Q 2V92 2V9J 2Y8L 2Y8Q 2Y94 2YA3 4EAI 4EAJ
Enriched GO Terms of Interacting Partners?		Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Arrest Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Glycogen Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Glycolytic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Cell Cycle Energy Reserve Metabolic Process Regulation Of Cell Cycle Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Biosynthetic Process Cellular Macromolecule Biosynthetic Process Polysaccharide Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Organelle Organization Gene Expression Cell Cycle Process Positive Regulation Of Phosphorylation RNA Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Fatty Acid Biosynthetic Process Cellular Process Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Binding Regulation Of Metabolic Process Regulation Of Carbohydrate Metabolic Process Regulation Of Phosphorylation Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Death	Fatty Acid Biosynthetic Process Cell Cycle Arrest Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Cellular Response To Peptide Hormone Stimulus Fatty Acid Metabolic Process Cellular Response To Peptide Mitochondrion Organization Negative Regulation Of Cell Cycle Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Cellular Response To Hormone Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Response To Organonitrogen Compound Membrane Organization Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Response To Hormone Cellular Lipid Metabolic Process Carboxylic Acid Metabolic Process Cell Cycle Process Protein Heterooligomerization Regulation Of Protein Phosphorylation Organic Acid Metabolic Process Lipid Metabolic Process Regulation Of Phosphorylation Protein Phosphorylation Cell Cycle Regulation Of Phosphorus Metabolic Process Phosphorylation Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Protein Oligomerization Small Molecule Metabolic Process Carnitine Shuttle Regulation Of Catalytic Activity Response To Organic Substance Carnitine Transmembrane Transport Carnitine Transport Phosphate-containing Compound Metabolic Process Quaternary Ammonium Group Transport Cell Surface Receptor Signaling Pathway Organelle Organization
Tagcloud ?			aetiology ancestry college direction equivocal european europeans gckr genotyped gout hlf inconsistency inhbc loci maaori maf meeting obvious opposing pacific pdzk1 polynesian replicated rheumatology sizes slc16a9 slc22a11 urate zealand
Tagcloud (Difference) ?			aetiology ancestry college direction equivocal european europeans gckr genotyped gout hlf inconsistency inhbc loci maaori maf meeting obvious opposing pacific pdzk1 polynesian replicated rheumatology sizes slc16a9 slc22a11 urate zealand
Tagcloud (Intersection) ?