PRKAB2 and KLF15

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid, two hybrid)

		PRKAB2	KLF15
Gene Name		protein kinase, AMP-activated, beta 2 non-catalytic subunit	Kruppel-like factor 15
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol AMP-activated Protein Kinase Complex	Nucleus
	Molecular Function	AMP-activated Protein Kinase Activity Protein Binding Identical Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Energy Reserve Metabolic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Carnitine Shuttle Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Regulation Of Protein Kinase Activity Membrane Organization	Transcription, DNA-templated Glial Cell Differentiation Cardiac Muscle Hypertrophy In Response To Stress Glucose Transport Positive Regulation Of Transcription From RNA Polymerase II Promoter Glomerular Visceral Epithelial Cell Differentiation Cellular Response To Peptide Negative Regulation Of Peptidyl-lysine Acetylation
Pathways		Organelle biogenesis and maintenance Integration of energy metabolism Metabolism of lipids and lipoproteins Regulation of Rheb GTPase activity by AMPK IRS-mediated signalling mTOR signalling Translocation of GLUT4 to the plasma membrane Import of palmitoyl-CoA into the mitochondrial matrix mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Fatty acid, triacylglycerol, and ketone body metabolism Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Mitochondrial biogenesis IRS-mediated signalling Activation of PPARGC1A (PGC-1alpha) by phosphorylation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade
Drugs		Adenosine monophosphate
Diseases
GWAS			Metabolite levels ( 23378610)
Protein-Protein Interactions		70 interactors: ADAMTSL4 BANP BEND5 BLZF1 CALCOCO2 CASP6 CCDC33 CCDC36 CDX4 CREB3L1 CRX CSNK2B DAO DDIT4L DICER1 DST EPM2A FAM208B FDX1 FLNC GATA1 GATAD2B GET4 GNB2L1 GOLGA2 GRN IKZF1 IKZF3 KCTD5 KLF15 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-4 LZTS2 MAGED1 MDFI MEOX2 NEBL PIAS2 PRDM14 PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 PSME3 PYGM RBPMS REL RHEBL1 RIMBP3 SPRY2 STX11 STX19 TADA2A TCF4 TP53BP2 TRAF2 TRIM10 UBXN11 YY1AP1 ZBTB32	5 interactors: PRKAB2 SNX13 SUV39H1 TCF21 ZBTB24
Entrez ID		5565	28999
HPRD ID		04117	07568
Ensembl ID		ENSG00000131791	ENSG00000163884
Uniprot IDs		O43741	Q9UIH9
PDB IDs		2F15 2V8Q 2V92 2V9J 2Y8L 2Y8Q 2Y94 2YA3 4EAI 4EAJ	2ENT
Enriched GO Terms of Interacting Partners?		Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Arrest Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Glycogen Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Glycolytic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Cell Cycle Energy Reserve Metabolic Process Regulation Of Cell Cycle Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Biosynthetic Process Cellular Macromolecule Biosynthetic Process Polysaccharide Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Organelle Organization Gene Expression Cell Cycle Process Positive Regulation Of Phosphorylation RNA Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Fatty Acid Biosynthetic Process Cellular Process Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Binding Regulation Of Metabolic Process Regulation Of Carbohydrate Metabolic Process Regulation Of Phosphorylation Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Death	Bronchiole Development Metanephric Mesenchymal Cell Differentiation Branchiomeric Skeletal Muscle Development Metanephric Glomerular Capillary Formation Histone H3-K9 Dimethylation Carnitine Shuttle Glomerular Capillary Formation Mesenchymal Cell Differentiation Involved In Kidney Development Lung Vasculature Development Histone H3-K9 Trimethylation Metanephric Glomerulus Vasculature Development Carnitine Transmembrane Transport Diaphragm Development Carnitine Transport Peptidyl-lysine Dimethylation Cell Differentiation Involved In Metanephros Development Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Metabolic Process Chromatin Silencing At RDNA Metanephric Glomerulus Development Glomerulus Morphogenesis Metanephric Mesenchyme Development Quaternary Ammonium Group Transport Negative Regulation Of Circadian Rhythm Regulation Of Androgen Receptor Signaling Pathway Histone H3-K9 Methylation Glomerulus Vasculature Development Sex Determination Peptidyl-lysine Trimethylation Embryonic Digestive Tract Morphogenesis Sertoli Cell Differentiation Regulation Of Fatty Acid Biosynthetic Process Biosynthetic Process Chromatin Silencing Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Histone H3-K9 Modification Transcription, DNA-templated Immune System Development Cell Differentiation Involved In Kidney Development Metanephric Nephron Development Long-chain Fatty Acid Transport RNA Biosynthetic Process Ammonium Transmembrane Transport Embryonic Digestive Tract Development Spleen Development Negative Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?			adig adipogenesis adipogenic axin bmp2 cebpa cebpb damiana ddit3 dlk ebpalpha fasn favors fgf10 fgf2 foxo1 guarana klf2 lep lpl mate ppargamma2 resveratrol sirt2 srebf1 synergy ucp1 yerba ygd
Tagcloud (Difference) ?			adig adipogenesis adipogenic axin bmp2 cebpa cebpb damiana ddit3 dlk ebpalpha fasn favors fgf10 fgf2 foxo1 guarana klf2 lep lpl mate ppargamma2 resveratrol sirt2 srebf1 synergy ucp1 yerba ygd
Tagcloud (Intersection) ?