PRKAB2 and UBXN11

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid, two hybrid)

		PRKAB2	UBXN11
Gene Name		protein kinase, AMP-activated, beta 2 non-catalytic subunit	UBX domain protein 11
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol AMP-activated Protein Kinase Complex	Cytoplasm Cytoskeleton
	Molecular Function	AMP-activated Protein Kinase Activity Protein Binding Identical Protein Binding	Ubiquitin Binding
	Biological Process	Energy Reserve Metabolic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Carnitine Shuttle Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Regulation Of Protein Kinase Activity Membrane Organization	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Organelle biogenesis and maintenance Integration of energy metabolism Metabolism of lipids and lipoproteins Regulation of Rheb GTPase activity by AMPK IRS-mediated signalling mTOR signalling Translocation of GLUT4 to the plasma membrane Import of palmitoyl-CoA into the mitochondrial matrix mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Fatty acid, triacylglycerol, and ketone body metabolism Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Mitochondrial biogenesis IRS-mediated signalling Activation of PPARGC1A (PGC-1alpha) by phosphorylation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade
Drugs		Adenosine monophosphate
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		70 interactors: ADAMTSL4 BANP BEND5 BLZF1 CALCOCO2 CASP6 CCDC33 CCDC36 CDX4 CREB3L1 CRX CSNK2B DAO DDIT4L DICER1 DST EPM2A FAM208B FDX1 FLNC GATA1 GATAD2B GET4 GNB2L1 GOLGA2 GRN IKZF1 IKZF3 KCTD5 KLF15 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-4 LZTS2 MAGED1 MDFI MEOX2 NEBL PIAS2 PRDM14 PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 PSME3 PYGM RBPMS REL RHEBL1 RIMBP3 SPRY2 STX11 STX19 TADA2A TCF4 TP53BP2 TRAF2 TRIM10 UBXN11 YY1AP1 ZBTB32	18 interactors: AES C6orf165 EIF4E EIF4E2 ENKD1 PRKAA1 PRKAB2 PSMA1 RHOBTB3 RND1 RND2 RND3 RNF213 SCNM1 SH2D4A TRAF2 USHBP1 ZFYVE9
Entrez ID		5565	91544
HPRD ID		04117	10245
Ensembl ID		ENSG00000131791	ENSG00000158062
Uniprot IDs		O43741	Q5T124
PDB IDs		2F15 2V8Q 2V92 2V9J 2Y8L 2Y8Q 2Y94 2YA3 4EAI 4EAJ
Enriched GO Terms of Interacting Partners?		Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Arrest Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Glycogen Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Glycolytic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Cell Cycle Energy Reserve Metabolic Process Regulation Of Cell Cycle Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Biosynthetic Process Cellular Macromolecule Biosynthetic Process Polysaccharide Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Organelle Organization Gene Expression Cell Cycle Process Positive Regulation Of Phosphorylation RNA Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Fatty Acid Biosynthetic Process Cellular Process Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Binding Regulation Of Metabolic Process Regulation Of Carbohydrate Metabolic Process Regulation Of Phosphorylation Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Death	Signal Transduction Signaling Cell Communication Cellular Response To Stimulus Insulin Receptor Signaling Pathway Protein Autoubiquitination Cellular Response To Insulin Stimulus Response To Stimulus Response To Organic Substance Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Cellular Response To Organic Substance Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Response To Insulin Response To Cytokine Regulation Of Cellular Protein Metabolic Process Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Cellular Response To Reactive Oxygen Species Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Glucose Import In Response To Insulin Stimulus Regulation Of Cell Cycle Cytokine-mediated Signaling Pathway Response To Camptothecin Positive Regulation Of Anoikis Negative Regulation Of Cell Cycle Response To Peptide Hormone Cellular Response To Organonitrogen Compound Protein Heterooligomerization Response To Peptide Fatty Acid Biosynthetic Process Metabolic Process Cell Cycle Process Regulation Of Lipid Biosynthetic Process Negative Regulation Of Sphingolipid Biosynthetic Process Regulation Of Cellular Process Cell Cycle Arrest Regulation Of Protein Binding Negative Regulation Of Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transferase Activity Regulation Of Ceramide Biosynthetic Process Protein Ubiquitination Protein Polyubiquitination Negative Regulation Of Signaling
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