PRKAB2 and DST

Number of citations of the paper that reports this interaction (PMID 19616115)
4

Data Source:
BioGRID (two hybrid)

		PRKAB2	DST
Gene Name		protein kinase, AMP-activated, beta 2 non-catalytic subunit	dystonin
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol AMP-activated Protein Kinase Complex	Basement Membrane Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Membrane Cytosol Intermediate Filament Focal Adhesion Cell Cortex Basal Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Z Disc Hemidesmosome Axon Cell Leading Edge H Zone Microtubule Plus-end Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	AMP-activated Protein Kinase Activity Protein Binding Identical Protein Binding	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Protein Homodimerization Activity Microtubule Plus-end Binding
	Biological Process	Energy Reserve Metabolic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Carnitine Shuttle Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Regulation Of Protein Kinase Activity Membrane Organization	Microtubule Cytoskeleton Organization Cytoskeleton Organization Cell Cycle Arrest Cell Adhesion Integrin-mediated Signaling Pathway Response To Wounding Maintenance Of Cell Polarity Extracellular Matrix Organization Hemidesmosome Assembly Intermediate Filament Cytoskeleton Organization Cell Motility
Pathways		Organelle biogenesis and maintenance Integration of energy metabolism Metabolism of lipids and lipoproteins Regulation of Rheb GTPase activity by AMPK IRS-mediated signalling mTOR signalling Translocation of GLUT4 to the plasma membrane Import of palmitoyl-CoA into the mitochondrial matrix mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Fatty acid, triacylglycerol, and ketone body metabolism Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Mitochondrial biogenesis IRS-mediated signalling Activation of PPARGC1A (PGC-1alpha) by phosphorylation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade	Cell junction organization Type I hemidesmosome assembly
Drugs		Adenosine monophosphate
Diseases
GWAS
Protein-Protein Interactions		70 interactors: ADAMTSL4 BANP BEND5 BLZF1 CALCOCO2 CASP6 CCDC33 CCDC36 CDX4 CREB3L1 CRX CSNK2B DAO DDIT4L DICER1 DST EPM2A FAM208B FDX1 FLNC GATA1 GATAD2B GET4 GNB2L1 GOLGA2 GRN IKZF1 IKZF3 KCTD5 KLF15 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-4 LZTS2 MAGED1 MDFI MEOX2 NEBL PIAS2 PRDM14 PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 PSME3 PYGM RBPMS REL RHEBL1 RIMBP3 SPRY2 STX11 STX19 TADA2A TCF4 TP53BP2 TRAF2 TRIM10 UBXN11 YY1AP1 ZBTB32	26 interactors: APC CALM1 CDC5L CELSR3 CEP63 COL17A1 DCTN1 DISC1 DTNBP1 ERBB2IP EXOC1 ITGB4 ITSN2 KIAA0368 KIAA1549 KRT14 KRT5 MAPK6 NFYC PAK2 PRKAB2 PRKD2 SH3BP5 SMAD9 TNIK TRAF3IP1
Entrez ID		5565	667
HPRD ID		04117	00222
Ensembl ID		ENSG00000131791	ENSG00000151914
Uniprot IDs		O43741	B4DGY0 B4DSS9 Q03001 Q6P0N6
PDB IDs		2F15 2V8Q 2V92 2V9J 2Y8L 2Y8Q 2Y94 2YA3 4EAI 4EAJ	3GJO
Enriched GO Terms of Interacting Partners?		Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Arrest Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Glycogen Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Glycolytic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Cell Cycle Energy Reserve Metabolic Process Regulation Of Cell Cycle Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Biosynthetic Process Cellular Macromolecule Biosynthetic Process Polysaccharide Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Organelle Organization Gene Expression Cell Cycle Process Positive Regulation Of Phosphorylation RNA Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Fatty Acid Biosynthetic Process Cellular Process Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Binding Regulation Of Metabolic Process Regulation Of Carbohydrate Metabolic Process Regulation Of Phosphorylation Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Death	Hemidesmosome Assembly Cell-substrate Junction Assembly Cell Junction Assembly Signaling Organelle Organization Cell Communication Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Intracellular Signal Transduction Regulation Of Kinase Activity Anatomical Structure Development Regulation Of Phosphorylation Cell Cycle Nervous System Development Developmental Process Cellular Component Assembly Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Epithelium Development Regulation Of Cellular Protein Metabolic Process Microtubule-based Process Cytoskeleton Organization Response To Stimulus Cell Projection Organization Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Epidermis Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cell Projection Assembly Tissue Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Negative Regulation Of Protein Phosphorylation Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport System Development Regulation Of Catalytic Activity Cellular Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cell Adhesion Regulation Of Signal Transduction
Tagcloud ?			125i alanine amines analogous asked attach attached attaches attempted b2 bradykinin bromide covalently cyanogen disuccinimidyl epsilon exchanged homobifunctional immunoidentification k174a labeling linker lys172 lys174 reacts reagent tartarate tyr8 worked
Tagcloud (Difference) ?			125i alanine amines analogous asked attach attached attaches attempted b2 bradykinin bromide covalently cyanogen disuccinimidyl epsilon exchanged homobifunctional immunoidentification k174a labeling linker lys172 lys174 reacts reagent tartarate tyr8 worked
Tagcloud (Intersection) ?