ADAMTSL4 and SPATA8

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ADAMTSL4	SPATA8
Gene Name		ADAMTS-like 4	spermatogenesis associated 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Interstitial Matrix Endoplasmic Reticulum Lumen
	Molecular Function	Protease Binding Metalloendopeptidase Activity Protein Binding
	Biological Process	Protein O-linked Glycosylation Proteolysis Apoptotic Process Extracellular Matrix Organization Protein O-linked Fucosylation Positive Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Post-translational protein modification O-glycosylation of TSR domain-containing proteins O-linked glycosylation
Drugs
Diseases
GWAS		Rhegmatogenous retinal detachment ( 23585552)	Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Obesity-related traits ( 23251661)
Protein-Protein Interactions		106 interactors: ADAMTSL5 AMMECR1 APOL6 AQP1 ARNT2 ASPSCR1 C19orf66 C6orf165 CATSPER1 CCDC26 CHCHD2 CLEC18A COL8A1 CPNE7 CREB5 CST2 CTSB CXCL16 CYP2S1 DGCR6 DIP2A DLK2 DNPEP DSCR8 EIF4E2 FAH FAM124B FARS2 FBLN1 FBXW5 FHL3 FKBP1B FLNA FRS3 GATA2 GIP GLRX3 GMCL1P1 GNE GNMT GOLGA8EP HGF HOXA1 KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2D LCE3C LCE3E LCE4A LGALS14 LINC00671 LMO1 LMO2 LONRF1 LRRC29 MAPKBP1 MID2 MORN3 MVP NATD1 NMUR2 NTF4 NTN4 OLFM3 PID1 PIN1 PLSCR1 PRKAB2 PTGER3 RAB2B RCHY1 RHOJ SALL2 SLC23A1 SLC6A20 SMARCC1 SORBS3 SPATA8 SPINK2 SPRY2 STK16 SUSD6 TAPBPL TCEA2 TMEM150A TMSB4XP6 TOP3B TRIM42 TRIP6 TSSK3 TUBGCP4 ZNF417 ZNF587	14 interactors: ADAMTSL4 CMTM5 GOPC KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP9-2 MDFI MTUS2 NOTCH2NL PLSCR1 PSMA3 RBPMS
Entrez ID		54507	145946
HPRD ID		18237	15432
Ensembl ID		ENSG00000143382	ENSG00000185594
Uniprot IDs		F8WAD0 Q6UY14 Q9UFG7	Q6RVD6
PDB IDs
Enriched GO Terms of Interacting Partners?		Multicellular Organismal Development Keratinization Organ Development Developmental Process Keratinocyte Differentiation System Development Anatomical Structure Development Epidermis Development Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Epidermal Cell Differentiation Sensory Organ Development Response To Organic Substance Organic Anion Transport Positive Regulation Of Neuron Projection Regeneration Regulation Of Transcription From RNA Polymerase II Promoter Epithelium Development Cellular Response To Thyroid Hormone Stimulus MRNA Transcription From RNA Polymerase II Promoter Skin Development Positive Regulation Of Transcription, DNA-templated Transepithelial Transport Semicircular Canal Development Positive Regulation Of Gene Expression Regulation Of Branching Involved In Salivary Gland Morphogenesis MRNA Transcription Response To Thyroid Hormone Negative Regulation Of Hydrolase Activity Cell Differentiation Negative Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process	Cytoplasmic Sequestering Of Protein Regulation Of Intracellular Protein Transport Regulation Of Intracellular Transport Cytoplasmic Sequestering Of CFTR Protein Negative Regulation Of Intracellular Protein Transport Negative Regulation Of Intracellular Transport Regulation Of Protein Transport Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Regulation Of Establishment Of Protein Localization Regulation Of Protein Import Into Nucleus Negative Regulation Of Protein Transport Negative Regulation Of Wnt Signaling Pathway Regulation Of Protein Localization Regulation Of Protein Localization To Nucleus Phosphatidylserine Biosynthetic Process Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of Protein Modification Process Regulation Of Golgi To Plasma Membrane Protein Transport Apoptotic Process Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Programmed Cell Death Protein O-linked Fucosylation Phospholipid Scrambling Regulation Of Cellular Localization Cell Death Death Regulation Of Cellular Process Regulation Of Wnt Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of SMAD Protein Import Into Nucleus Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Catalytic Activity Regulation Of SMAD Protein Import Into Nucleus Apical Protein Localization Trophoblast Giant Cell Differentiation Positive Regulation Of Protein Metabolic Process Response To Interferon-beta Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Transport Cytoplasmic Sequestering Of Transcription Factor Dorsal/ventral Axis Specification Negative Regulation Of Myoblast Differentiation
Tagcloud ?		abl baalc bcr cd83 ciita council ctnnd1 e2993 gab1 gli1 hubs il15 irs1 p185bcr p210bcr pilrb ptp4a3 rab21 serpinb9 spp1 spry1 supervised transcriptomic tspan16 ukall underexpressed unsupervised xbp1 xii
Tagcloud (Difference) ?		abl baalc bcr cd83 ciita council ctnnd1 e2993 gab1 gli1 hubs il15 irs1 p185bcr p210bcr pilrb ptp4a3 rab21 serpinb9 spp1 spry1 supervised transcriptomic tspan16 ukall underexpressed unsupervised xbp1 xii
Tagcloud (Intersection) ?