ADAMTSL4 and FRS3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ADAMTSL4	FRS3
Gene Name		ADAMTS-like 4	fibroblast growth factor receptor substrate 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Interstitial Matrix Endoplasmic Reticulum Lumen	Plasma Membrane
	Molecular Function	Protease Binding Metalloendopeptidase Activity Protein Binding	Fibroblast Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding
	Biological Process	Protein O-linked Glycosylation Proteolysis Apoptotic Process Extracellular Matrix Organization Protein O-linked Fucosylation Positive Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process	Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway
Pathways		Post-translational protein modification O-glycosylation of TSR domain-containing proteins O-linked glycosylation	Signaling by FGFR in disease FRS2-mediated cascade Downstream signaling of activated FGFR Signaling by FGFR
Drugs
Diseases
GWAS		Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		106 interactors: ADAMTSL5 AMMECR1 APOL6 AQP1 ARNT2 ASPSCR1 C19orf66 C6orf165 CATSPER1 CCDC26 CHCHD2 CLEC18A COL8A1 CPNE7 CREB5 CST2 CTSB CXCL16 CYP2S1 DGCR6 DIP2A DLK2 DNPEP DSCR8 EIF4E2 FAH FAM124B FARS2 FBLN1 FBXW5 FHL3 FKBP1B FLNA FRS3 GATA2 GIP GLRX3 GMCL1P1 GNE GNMT GOLGA8EP HGF HOXA1 KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2D LCE3C LCE3E LCE4A LGALS14 LINC00671 LMO1 LMO2 LONRF1 LRRC29 MAPKBP1 MID2 MORN3 MVP NATD1 NMUR2 NTF4 NTN4 OLFM3 PID1 PIN1 PLSCR1 PRKAB2 PTGER3 RAB2B RCHY1 RHOJ SALL2 SLC23A1 SLC6A20 SMARCC1 SORBS3 SPATA8 SPINK2 SPRY2 STK16 SUSD6 TAPBPL TCEA2 TMEM150A TMSB4XP6 TOP3B TRIM42 TRIP6 TSSK3 TUBGCP4 ZNF417 ZNF587	20 interactors: ADAMTSL4 AES BMPR2 FGFR1 GATA1 GRB2 KARS MAPK1 NOTCH2NL NTRK1 NTRK2 PLSCR1 PRKCI PTPN11 RFX6 RND1 SPERT SPRY2 TCF4 TRIP6
Entrez ID		54507	10817
HPRD ID		18237	06373
Ensembl ID		ENSG00000143382	ENSG00000137218
Uniprot IDs		F8WAD0 Q6UY14 Q9UFG7	O43559
PDB IDs			2KUP 2KUQ 2YS5 2YT2
Enriched GO Terms of Interacting Partners?		Multicellular Organismal Development Keratinization Organ Development Developmental Process Keratinocyte Differentiation System Development Anatomical Structure Development Epidermis Development Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Epidermal Cell Differentiation Sensory Organ Development Response To Organic Substance Organic Anion Transport Positive Regulation Of Neuron Projection Regeneration Regulation Of Transcription From RNA Polymerase II Promoter Epithelium Development Cellular Response To Thyroid Hormone Stimulus MRNA Transcription From RNA Polymerase II Promoter Skin Development Positive Regulation Of Transcription, DNA-templated Transepithelial Transport Semicircular Canal Development Positive Regulation Of Gene Expression Regulation Of Branching Involved In Salivary Gland Morphogenesis MRNA Transcription Response To Thyroid Hormone Negative Regulation Of Hydrolase Activity Cell Differentiation Negative Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Signaling Cellular Response To Growth Factor Stimulus Response To Growth Factor Cell Differentiation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Cell Development Response To External Stimulus Organ Development Positive Regulation Of Protein Phosphorylation Response To Organic Substance Multicellular Organismal Development Positive Regulation Of Cellular Metabolic Process Generation Of Neurons Positive Regulation Of Intracellular Signal Transduction System Development Positive Regulation Of Neuron Differentiation Neurogenesis Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Protein Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of MAPK Cascade Response To Fibroblast Growth Factor Neuron Development Developmental Process Intracellular Signal Transduction Axon Guidance Organ Morphogenesis Positive Regulation Of Neurogenesis Cell Surface Receptor Signaling Pathway Signaling Cellular Response To Insulin Stimulus Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Neuron Projection Development Cell Communication Regulation Of Protein Phosphorylation Cell Morphogenesis Involved In Differentiation Epithelium Development
Tagcloud ?		abl baalc bcr cd83 ciita council ctnnd1 e2993 gab1 gli1 hubs il15 irs1 p185bcr p210bcr pilrb ptp4a3 rab21 serpinb9 spp1 spry1 supervised transcriptomic tspan16 ukall underexpressed unsupervised xbp1 xii	2yf 4yf adapters alleviated anophthalmia coordinated ectodermal embryogenesis eye fgf fgfr laevis maternally microphthalmia mo morphants morpholino oligonucleotide pax6 pi3 placode rescue served shp2 vertebrate xenopus xfrs3 zygotically
Tagcloud (Difference) ?		abl baalc bcr cd83 ciita council ctnnd1 e2993 gab1 gli1 hubs il15 irs1 p185bcr p210bcr pilrb ptp4a3 rab21 serpinb9 spp1 spry1 supervised transcriptomic tspan16 ukall underexpressed unsupervised xbp1 xii	2yf 4yf adapters alleviated anophthalmia coordinated ectodermal embryogenesis eye fgf fgfr laevis maternally microphthalmia mo morphants morpholino oligonucleotide pax6 pi3 placode rescue served shp2 vertebrate xenopus xfrs3 zygotically
Tagcloud (Intersection) ?