ADAMTSL4 and PKN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ADAMTSL4	PKN1
Description		ADAMTS like 4	protein kinase N1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Interstitial Matrix Endoplasmic Reticulum Lumen Extracellular Matrix	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Membrane Midbody Cytoplasmic Vesicle Cleavage Furrow Protein-containing Complex
	Molecular Function	Protease Binding Protein Binding Identical Protein Binding	Nucleotide Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Histone H3T11 Kinase Activity Histone Binding Histone Deacetylase Binding Nuclear Androgen Receptor Binding Protein Serine Kinase Activity
	Biological Process	Epithelial Cell Development Apoptotic Process Extracellular Matrix Organization Positive Regulation Of Apoptotic Process Pigment Cell Development	B Cell Homeostasis B Cell Apoptotic Process Regulation Of Germinal Center Formation Regulation Of Immunoglobulin Production Renal System Process Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Hyperosmotic Response Signal Transduction Epithelial Cell Migration Negative Regulation Of B Cell Proliferation Intracellular Signal Transduction Post-translational Protein Modification Positive Regulation Of DNA-templated Transcription Spleen Development Regulation Of Androgen Receptor Signaling Pathway Regulation Of Cell Motility
Pathways		Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins	RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle
Drugs			Fostamatinib
Diseases		Ectopia lentis
GWAS		Appendicular lean mass ( 33097823) Asthma ( 32296059) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Migraine ( 27322543) Refractive error ( 32231278) Rhegmatogenous retinal detachment ( 23585552) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Pancreatic cancer ( 30206226) Urolithiasis ( 30975718)
Interacting Genes		212 interacting genes: ADAM12 ADAMTSL5 ALPP AMMECR1 APOL6 AQP1 ARNT2 ASPSCR1 ATG9A BAG4 BANF2 BOLA2 BOLA2B BRME1 CATSPER1 CBX3 CCDC26 CFAP206 CHCHD2 CHERP CHIC2 CHRD CHRNG CLEC18A COL8A1 CPNE7 CREB5 CST2 CTSB CXCL16 CYP2S1 CYSRT1 DGCR6 DGCR6L DIP2A DLK2 DNPEP DSCR8 EFEMP2 EIF4E2 EPDR1 ERCC3 EXOSC5 FAH FAM124B FARS2 FBLN1 FBXL9P FBXO17 FBXW5 FHL3 FKBP1B FLNA FRS3 FXR1 GATA2 GIP GLRX3 GLYCTK GMCL2 GNE GNG13 GNMT GOLGA8EP GSTP1 GUCD1 HEXIM2 HGF HNRNPLL HOXA1 HOXC8 HSD3B7 INS IP6K1 ITGB2 ITGB4 JOSD1 KCTD7 KCTD9 KIF1A KLHL38 KRTAP1-1 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP19-2 KRTAP21-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 LCE1A LCE1B LCE1C LCE1D LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LGALS14 LHX4 LINC00671 LMO1 LMO2 LMO4 LNX1 LONRF1 LRFN4 MAGOHB MAPKBP1 MGAT5B MID2 MKRN3 MORN3 MVP MYLIP MYO15B NATD1 NBPF19 NEK8 NFKBID NMUR2 NOTCH2NLA NR4A3 NTAQ1 NTF4 NTN4 NUFIP2 OLFM3 OTX1 PCSK5 PID1 PIN1 PKN1 PLSCR1 PLSCR4 POLD1 POLR1C POU4F2 PRKAB2 PRR19 PTGER3 PTPMT1 QPRT R3HDM2 RAB2B RCHY1 RGL2 RHOJ RPS19BP1 RUNX1T1 SALL2 SCNM1 SHFL SLC13A5 SLC23A1 SLC6A20 SLIT1 SMARCC1 SORBS3 SPATA8 SPINK2 SPRY1 SPRY2 STK16 SUSD6 TAPBPL TCEA2 TFAP2D TGFB1 THAP6 TMEM150A TMSB4XP6 TOP3B TRIM42 TRIM55 TRIM63 TRIP6 TSSK3 TUBGCP4 USP21 VASN VENTX VWC2 ZFHX2 ZNF330 ZNF414 ZNF417 ZNF587	83 interacting genes: ACTN1 ADAMTSL4 AKAP9 ARHGAP10 ARHGAP26 ARSA BLZF1 BUD23 CASP3 CCDC136 CCDC138 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57 CEP57L1 CEP70 CYSRT1 DISC1 DNAAF19 DYDC1 EIF3F GOLGA2 GOLGA6L9 H3C14 HAP1 HAUS1 HDAC5 HOMER3 HSF2BP INTS11 KIAA1328 KRT15 KRT16 KRT19 KRT31 KRT34 KRT35 KRT36 KRT37 LRRC61 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 MID2 MIPOL1 MKRN3 MTDH MTUS2 NEFH NEFL NEUROD2 PDPK1 PICK1 PLD1 PNMA1 POU6F2 PSMB4 RAB3IP RHOA RHOB SERTAD3 SMYD3 SPAG5 SPRR2D SSX2IP STX11 SYCE3 TNFRSF1B TRAF1 TRAF2 TSGA10 UBR2 USHBP1 VIM ZFAND6 ZNF282 ZRANB1
Entrez ID		54507	5585
HPRD ID		18237	03019
Ensembl ID		ENSG00000143382	ENSG00000123143
Uniprot IDs		A0A669KBE7 B7ZMJ3 Q6UY14	Q16512
PDB IDs			1CXZ 1URF 2RMK 4NKG 4OTD 4OTG 4OTH 4OTI
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratinization Keratin Filament Epidermis Development Protein Binding Tissue Development Identical Protein Binding Hair Cycle	Cytoskeleton Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Intermediate Filament Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Organelle Organization Keratin Filament Morphogenesis Of An Epithelium Structural Constituent Of Cytoskeleton Cytosol Identical Protein Binding Structural Molecule Activity Protein Binding Tissue Morphogenesis Microtubule Binding Regulation Of Microtubule-based Process Microtubule Cytoplasm Regulation Of Microtubule Cytoskeleton Organization Centrosome Epithelial Cell Differentiation Developmental Process Microtubule Cytoskeleton Organization Epidermis Development Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton Postsynaptic Intermediate Filament Cytoskeleton Organization Neurofilament Bundle Assembly Protein Localization To Cytoskeleton Intermediate Filament Cytoskeleton Cellular Component Assembly Microtubule-based Process Postsynaptic Intermediate Filament Cytoskeleton Tumor Necrosis Factor Receptor Superfamily Complex Cellular Developmental Process Axon Development Neurofibrillary Tangle Regulation Of Synapse Maturation Tumor Necrosis Factor Binding Gamma-tubulin Binding Intermediate Filament Bundle Assembly Cell Projection Organization Regulation Of Organelle Transport Along Microtubule Response To Electrical Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Neurofilament Cytoskeleton Organization Thioesterase Binding Focal Adhesion
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