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PRKAB2 and FLNC
Number of citations of the paper that reports this interaction (PMID
19616115
)
4
Data Source:
BioGRID
(two hybrid)
PRKAB2
FLNC
Gene Name
protein kinase, AMP-activated, beta 2 non-catalytic subunit
filamin C, gamma
Image
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytosol
AMP-activated Protein Kinase Complex
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Focal Adhesion
Sarcoplasm
Z Disc
Sarcolemma
Costamere
Molecular Function
AMP-activated Protein Kinase Activity
Protein Binding
Identical Protein Binding
Protein Binding
Cytoskeletal Protein Binding
Ankyrin Binding
Actin Filament Binding
Biological Process
Energy Reserve Metabolic Process
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Carnitine Shuttle
Organelle Organization
Mitochondrion Organization
Cell Cycle Arrest
Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Fatty Acid Biosynthetic Process
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Regulation Of Protein Kinase Activity
Membrane Organization
Cell Junction Assembly
Muscle Fiber Development
Pathways
Organelle biogenesis and maintenance
Integration of energy metabolism
Metabolism of lipids and lipoproteins
Regulation of Rheb GTPase activity by AMPK
IRS-mediated signalling
mTOR signalling
Translocation of GLUT4 to the plasma membrane
Import of palmitoyl-CoA into the mitochondrial matrix
mTOR signalling
IGF1R signaling cascade
IRS-related events triggered by IGF1R
Energy dependent regulation of mTOR by LKB1-AMPK
PKB-mediated events
PI3K Cascade
Signaling by Insulin receptor
Fatty acid, triacylglycerol, and ketone body metabolism
Insulin receptor signalling cascade
Regulation of AMPK activity via LKB1
IRS-related events
Mitochondrial biogenesis
IRS-mediated signalling
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
AMPK inhibits chREBP transcriptional activation activity
PKB-mediated events
PI3K Cascade
Cell junction organization
Cell-extracellular matrix interactions
Drugs
Adenosine monophosphate
Diseases
GWAS
Protein-Protein Interactions
70 interactors:
ADAMTSL4
BANP
BEND5
BLZF1
CALCOCO2
CASP6
CCDC33
CCDC36
CDX4
CREB3L1
CRX
CSNK2B
DAO
DDIT4L
DICER1
DST
EPM2A
FAM208B
FDX1
FLNC
GATA1
GATAD2B
GET4
GNB2L1
GOLGA2
GRN
IKZF1
IKZF3
KCTD5
KLF15
KRT40
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP4-12
KRTAP4-2
KRTAP5-9
KRTAP9-2
KRTAP9-4
LZTS2
MAGED1
MDFI
MEOX2
NEBL
PIAS2
PRDM14
PRKAA1
PRKAA2
PRKAG1
PRKAG2
PRKAG3
PSME3
PYGM
RBPMS
REL
RHEBL1
RIMBP3
SPRY2
STX11
STX19
TADA2A
TCF4
TP53BP2
TRAF2
TRIM10
UBXN11
YY1AP1
ZBTB32
29 interactors:
ADRA1A
ADRA1B
ADRA1D
CAPN3
FURIN
HIPK3
INPPL1
KCND2
KY
MAP2K4
MYOT
MYOZ1
MYOZ2
MYOZ3
NPHP1
PHLDB2
PRKAB2
PRKCA
RPS6KA2
SGCD
SGCG
SYNPO2
TRIM54
TRIM55
TRIM63
USP25
WNK1
XIRP1
XIRP2
Entrez ID
5565
2318
HPRD ID
04117
00018
Ensembl ID
ENSG00000131791
ENSG00000128591
Uniprot IDs
O43741
Q14315
Q59H94
PDB IDs
2F15
2V8Q
2V92
2V9J
2Y8L
2Y8Q
2Y94
2YA3
4EAI
4EAJ
1V05
2D7M
2D7N
2D7O
2D7P
2D7Q
2K9U
2NQC
3V8O
Enriched GO Terms of Interacting Partners
?
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Cell Cycle Arrest
Transcription, DNA-templated
Regulation Of Gene Expression
RNA Biosynthetic Process
Glycogen Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Glycolytic Process
Regulation Of Transcription, DNA-templated
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Phosphorylation
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Protein Modification Process
Negative Regulation Of Cell Cycle
Energy Reserve Metabolic Process
Regulation Of Cell Cycle
Regulation Of RNA Metabolic Process
Positive Regulation Of Gene Expression
Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Polysaccharide Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Macromolecule Biosynthetic Process
Organelle Organization
Gene Expression
Cell Cycle Process
Positive Regulation Of Phosphorylation
RNA Metabolic Process
Regulation Of Protein Phosphorylation
Regulation Of Protein Metabolic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Signaling
Fatty Acid Biosynthetic Process
Cellular Process
Regulation Of Cellular Ketone Metabolic Process
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Transcription From RNA Polymerase II Promoter
Regulation Of Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Binding
Regulation Of Metabolic Process
Regulation Of Carbohydrate Metabolic Process
Regulation Of Phosphorylation
Regulation Of Generation Of Precursor Metabolites And Energy
Regulation Of Cell Death
Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure
Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback
Muscle Cell Development
Blood Circulation
Muscle Structure Development
Heart Development
Regulation Of Systemic Arterial Blood Pressure
Positive Regulation Of Blood Pressure
Cardiovascular System Development
Positive Regulation Of Systemic Arterial Blood Pressure
Adrenergic Receptor Signaling Pathway
Muscle Cell Differentiation
Regulation Of Blood Pressure
Negative Regulation Of The Force Of Heart Contraction Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure
Cardiac Muscle Tissue Development
Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure
Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine
Organ Development
Multicellular Organismal Development
Developmental Process
Regulation Of The Force Of Heart Contraction
Vasoconstriction
Positive Regulation Of The Force Of Heart Contraction By Chemical Signal
Muscle Organ Development
Positive Regulation Of Heart Rate By Epinephrine-norepinephrine
Peptidyl-threonine Phosphorylation
Striated Muscle Tissue Development
Striated Muscle Cell Development
System Development
Muscle Tissue Development
Regulation Of Heart Contraction
Anatomical Structure Development
Actin Cytoskeleton Organization
Regulation Of The Force Of Heart Contraction By Chemical Signal
Heart Contraction
Actin Filament-based Process
Myofibril Assembly
Cell Development
Regulation Of Blood Vessel Size
Cellular Response To Carbohydrate Stimulus
Regulation Of Tube Size
Striated Muscle Cell Differentiation
Adult Heart Development
Muscle System Process
Signaling
Organ Growth
Actomyosin Structure Organization
Cell Communication
Positive Regulation Of Heart Rate
Peptidyl-serine Phosphorylation
Tagcloud
?
adh6
aflatoxin
areca
arecoline
bard1
betel
brms1
ccnd2
cdk2ap1
cdkn1a
cdkn2b
chewing
exonic
fermented
fgfr4
gas1
hras
il12b
il8
indels
msh6
nbl1
nitrosamines
northeast
nut
quid
rassf1
tobacco
toxogenomic
Tagcloud (Difference)
?
adh6
aflatoxin
areca
arecoline
bard1
betel
brms1
ccnd2
cdk2ap1
cdkn1a
cdkn2b
chewing
exonic
fermented
fgfr4
gas1
hras
il12b
il8
indels
msh6
nbl1
nitrosamines
northeast
nut
quid
rassf1
tobacco
toxogenomic
Tagcloud (Intersection)
?