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PRKAB2 and CDX4
Number of citations of the paper that reports this interaction (PubMedID
24722188
)
69
Data Source:
BioGRID
(two hybrid, two hybrid)
PRKAB2
CDX4
Description
protein kinase AMP-activated non-catalytic subunit beta 2
caudal type homeobox 4
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nucleotide-activated Protein Kinase Complex
Chromatin
Nucleus
Molecular Function
AMP-activated Protein Kinase Activity
Protein Binding
Protein Kinase Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Lipid Metabolic Process
Fatty Acid Metabolic Process
Fatty Acid Biosynthetic Process
Signal Transduction
Cellular Response To Nutrient Levels
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Transcription By RNA Polymerase II
Blood Vessel Development
Placenta Development
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Embryonic Pattern Specification
Anterior/posterior Axis Specification
Anterior/posterior Pattern Specification
Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Digestive Tract Development
Labyrinthine Layer Development
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Macroautophagy
AMPK inhibits chREBP transcriptional activation activity
AMPK inhibits chREBP transcriptional activation activity
Carnitine shuttle
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation
Lipophagy
Activation of AMPK downstream of NMDARs
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs
Adenosine phosphate
Acetylsalicylic acid
Fostamatinib
Diseases
GWAS
Interacting Genes
172 interacting genes:
ABHD11
ACTMAP
ADAMTSL4
ANAPC11
ARID5A
AUNIP
AVP
BANP
BEND5
BLZF1
C2orf42
C3orf36
CALCOCO2
CASP2
CASP6
CCDC28B
CCDC33
CDC14B
CDSN
CDX4
CFAP68
CFP
CREB3L1
CRX
CSNK2B
CYSRT1
DAO
DDAH2
DDIT4L
DICER1
DOK3
DST
ELL2
EPM2A
ESM1
FDX1
FLNC
GATA1
GATAD2B
GCSAML
GET4
GOLGA2
GOLGA6L9
GORASP2
GPRASP3
GRAPL
GRN
GSC2
IHO1
IKZF1
IKZF3
IL37
IRAK1BP1
KATNBL1
KCTD5
KHDC4
KLF15
KRABD4
KRT31
KRT40
KRTAP1-1
KRTAP1-3
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP17-1
KRTAP2-3
KRTAP2-4
KRTAP3-3
KRTAP4-12
KRTAP4-2
KRTAP4-5
KRTAP5-9
KRTAP9-2
KRTAP9-3
KRTAP9-4
KRTAP9-8
LHX3
LRIF1
LZTS1
LZTS2
MAGED1
MAJIN
MDFI
MEOX2
METTL27
MORN3
NAB2
NEBL
NHLRC4
NUTM1
OXER1
PDE6G
PDE6H
PFDN5
PIAS2
PNMA1
PPP1R13B
PPP1R16A
PPP1R3B
PPP1R3C
PRDM14
PRKAA1
PRKAG1
PRKAG2
PSMD11
PSME3
PYGM
QKI
RAB3IP
RACK1
RBM48
RBPMS
REL
RHEBL1
RIMBP3
RNF144B
ROR2
RPH3AL
SAMD4A
SERTAD2
SMARCB1
SMUG1
SPRY1
SPRY2
SSC4D
SSX2IP
STX11
STX19
TADA2A
TASOR2
TCF12
TCF19
TCF4
TCF7L2
TGM7
TLE5
TNNI1
TP53
TP53BP2
TRAF1
TRAF2
TRIB3
TRIM10
TRIM14
TRIM35
TRIM42
TRIM54
TRIM55
TRIM63
TSR2
TTC23
UBXN11
USP54
VBP1
VPS28
WDR83
YPEL3
YY1AP1
ZBTB32
ZC2HC1C
ZFP90
ZMYND19
ZNF177
ZNF236
ZNF474
ZNF526
ZNF559-ZNF177
ZNF581
9 interacting genes:
BANP
CKS1B
HOXA5
LMO1
LMO2
PITX1
PRKAA1
PRKAA2
PRKAB2
Entrez ID
5565
1046
HPRD ID
04117
02065
Ensembl ID
ENSG00000131791
ENSG00000131264
Uniprot IDs
O43741
X5D2Z8
O14627
PDB IDs
2F15
2V8Q
2V92
2V9J
2Y8L
2Y8Q
2YA3
4CFH
4EAI
4EAJ
4RER
4REW
6B2E
7JHG
7JHH
7JIJ
7M74
Enriched GO Terms of Interacting Partners
?
Keratin Filament
Intermediate Filament
Protein Binding
Identical Protein Binding
AMP-activated Protein Kinase Activity
Regulation Of Carbohydrate Catabolic Process
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
P53 Binding
Glycogen Binding
Nucleotide-activated Protein Kinase Complex
AMP-activated Protein Kinase Activity
Nucleotide-activated Protein Kinase Complex
Histone H2BS36 Kinase Activity
[hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
Protein Localization To Lipid Droplet
Negative Regulation Of Tubulin Deacetylation
Regulation Of Tubulin Deacetylation
Negative Regulation Of Hepatocyte Apoptotic Process
Lipid Droplet Disassembly
Phosphatidylethanolamine Biosynthetic Process
Regulation Of Protein Deacetylation
Regulation Of Stress Granule Assembly
Fatty Acid Biosynthetic Process
Fatty Acid Homeostasis
Hepatocyte Apoptotic Process
Cellular Response To Prostaglandin E Stimulus
Phosphatidylcholine Biosynthetic Process
Positive Regulation Of Glycolytic Process
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Cellular Response To Prostaglandin Stimulus
Protein K6-linked Ubiquitination
Response To Prostaglandin E
Negative Regulation Of Epithelial Cell Apoptotic Process
Phosphatidylethanolamine Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Cholesterol Biosynthetic Process
Positive Regulation Of ATP Metabolic Process
Lipid Droplet Organization
Sterol Biosynthetic Process
Regulation Of Release Of Cytochrome C From Mitochondria
Epithelial Cell Apoptotic Process
Negative Regulation Of Translational Initiation
Carboxylic Acid Biosynthetic Process
Cellular Response To Nutrient Levels
Positive Regulation Of Translational Initiation
Cellular Response To Glucose Starvation
Positive Regulation Of Metabolic Process
Regulation Of Glycolytic Process
Regulation Of Epithelial Cell Apoptotic Process
Protein Localization To Lysosome
Fatty Acid Metabolic Process
Cellular Response To Amino Acid Starvation
Negative Regulation Of TORC1 Signaling
Regulation Of Carbohydrate Catabolic Process
Cellular Response To Xenobiotic Stimulus
Negative Regulation Of Glucosylceramide Biosynthetic Process
Cellular Response To Glucose Stimulus
Response To Amino Acid Starvation
Positive Regulation Of TORC1 Signaling
Phosphatidylcholine Metabolic Process
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Tagcloud (Intersection)
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