ADAMTSL4 and NTN4

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		ADAMTSL4	NTN4
Gene Name		ADAMTS-like 4	netrin 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Interstitial Matrix Endoplasmic Reticulum Lumen	Basement Membrane Plasma Membrane
	Molecular Function	Protease Binding Metalloendopeptidase Activity Protein Binding	Laminin-1 Binding
	Biological Process	Protein O-linked Glycosylation Proteolysis Apoptotic Process Extracellular Matrix Organization Protein O-linked Fucosylation Positive Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process	Axon Guidance Neuron Remodeling Extracellular Matrix Organization Regulation Of Branching Involved In Salivary Gland Morphogenesis By Extracellular Matrix-epithelial Cell Signaling
Pathways		Post-translational protein modification O-glycosylation of TSR domain-containing proteins O-linked glycosylation	Axon guidance Non-integrin membrane-ECM interactions Netrin-1 signaling
Drugs
Diseases
GWAS		Rhegmatogenous retinal detachment ( 23585552)	Breast cancer ( 23535729 23535733)
Protein-Protein Interactions		106 interactors: ADAMTSL5 AMMECR1 APOL6 AQP1 ARNT2 ASPSCR1 C19orf66 C6orf165 CATSPER1 CCDC26 CHCHD2 CLEC18A COL8A1 CPNE7 CREB5 CST2 CTSB CXCL16 CYP2S1 DGCR6 DIP2A DLK2 DNPEP DSCR8 EIF4E2 FAH FAM124B FARS2 FBLN1 FBXW5 FHL3 FKBP1B FLNA FRS3 GATA2 GIP GLRX3 GMCL1P1 GNE GNMT GOLGA8EP HGF HOXA1 KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2D LCE3C LCE3E LCE4A LGALS14 LINC00671 LMO1 LMO2 LONRF1 LRRC29 MAPKBP1 MID2 MORN3 MVP NATD1 NMUR2 NTF4 NTN4 OLFM3 PID1 PIN1 PLSCR1 PRKAB2 PTGER3 RAB2B RCHY1 RHOJ SALL2 SLC23A1 SLC6A20 SMARCC1 SORBS3 SPATA8 SPINK2 SPRY2 STK16 SUSD6 TAPBPL TCEA2 TMEM150A TMSB4XP6 TOP3B TRIM42 TRIP6 TSSK3 TUBGCP4 ZNF417 ZNF587	3 interactors: ADAMTSL4 KRTAP5-9 PLSCR1
Entrez ID		54507	59277
HPRD ID		18237	10121
Ensembl ID		ENSG00000143382	ENSG00000074527
Uniprot IDs		F8WAD0 Q6UY14 Q9UFG7	Q9HB63
PDB IDs
Enriched GO Terms of Interacting Partners?		Multicellular Organismal Development Keratinization Organ Development Developmental Process Keratinocyte Differentiation System Development Anatomical Structure Development Epidermis Development Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Epidermal Cell Differentiation Sensory Organ Development Response To Organic Substance Organic Anion Transport Positive Regulation Of Neuron Projection Regeneration Regulation Of Transcription From RNA Polymerase II Promoter Epithelium Development Cellular Response To Thyroid Hormone Stimulus MRNA Transcription From RNA Polymerase II Promoter Skin Development Positive Regulation Of Transcription, DNA-templated Transepithelial Transport Semicircular Canal Development Positive Regulation Of Gene Expression Regulation Of Branching Involved In Salivary Gland Morphogenesis MRNA Transcription Response To Thyroid Hormone Negative Regulation Of Hydrolase Activity Cell Differentiation Negative Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process	Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Phosphatidylserine Biosynthetic Process Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Phospholipid Scrambling Protein O-linked Fucosylation Response To Interferon-beta Phosphatidylserine Metabolic Process Positive Regulation Of ATPase Activity Fucosylation Regulation Of Mast Cell Activation Apoptotic Process Acute-phase Response Regulation Of ATPase Activity Programmed Cell Death Negative Regulation Of Viral Genome Replication Cell Death Death
Tagcloud ?		abl baalc bcr cd83 ciita council ctnnd1 e2993 gab1 gli1 hubs il15 irs1 p185bcr p210bcr pilrb ptp4a3 rab21 serpinb9 spp1 spry1 supervised transcriptomic tspan16 ukall underexpressed unsupervised xbp1 xii	absolute ascertained automated dense esr1 estimates heritability heritable loci mammographic menopausal mlk1 nondense percent rs10995190 rs17356907 rs2046210 rs6001930 rs9383938 rs9485372 sib sided swedish tab2 trait volume volumetric weaker znf365
Tagcloud (Difference) ?		abl baalc bcr cd83 ciita council ctnnd1 e2993 gab1 gli1 hubs il15 irs1 p185bcr p210bcr pilrb ptp4a3 rab21 serpinb9 spp1 spry1 supervised transcriptomic tspan16 ukall underexpressed unsupervised xbp1 xii	absolute ascertained automated dense esr1 estimates heritability heritable loci mammographic menopausal mlk1 nondense percent rs10995190 rs17356907 rs2046210 rs6001930 rs9383938 rs9485372 sib sided swedish tab2 trait volume volumetric weaker znf365
Tagcloud (Intersection) ?