PJA1 and USP51

Number of citations of the paper that reports this interaction (PubMedID 22626734)
34

Data Source:
BioGRID (enzymatic study)

		PJA1	USP51
Description		praja ring finger ubiquitin ligase 1	ubiquitin specific peptidase 51
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Chromosome
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Chromatin Binding Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Histone Binding Metal Ion Binding Histone H2A Deubiquitinase Activity
	Biological Process	Protein Ubiquitination Protein Catabolic Process	DNA Repair Proteolysis DNA Damage Response Regulation Of Cell Cycle Process Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Deubiquitination DNA Repair-dependent Chromatin Remodeling Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)	Educational attainment (years of education) ( 30038396) Mean corpuscular volume ( 29403010) Smoking initiation ( 24665060)
Interacting Genes		63 interacting genes: ABR ASCC2 ATP5F1C ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 DYRK1A EED ELAC1 ESPL1 EZH2 FGF12 GATD3 GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440	11 interacting genes: CDK4 CDK6 DGCR8 ELOC H2AC20 H2AC4 H2BC3 PJA1 USP15 USP21 USP28
Entrez ID		64219	158880
HPRD ID		02335	07167
Ensembl ID		ENSG00000181191	ENSG00000247746
Uniprot IDs		Q8NG27	Q70EK9
PDB IDs		2L0B
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Deubiquitinase Activity Cysteine-type Peptidase Activity Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Proteolysis Protein Modification Process Peptidase Activity Deubiquitinase Activity Cytosol ATP Binding Pronucleus Ubiquitin Binding Protein K48-linked Deubiquitination Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Chromatin Silencing Complex Protein Polyubiquitination Macromolecule Metabolic Process Facultative Heterochromatin Formation ESC/E(Z) Complex Nucleotide Binding Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Cysteine-type Endopeptidase Activity DNA Repair Regulation Of Proteasomal Protein Catabolic Process Mitotic Cytokinesis Transferase Activity Protein K63-linked Deubiquitination DNA Damage Response Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Hydrolase Activity Protein Modification By Small Protein Conjugation DeNEDDylase Activity Sex Chromatin DNA Metabolic Process Ubiquitin-protein Transferase Activity Cytoskeleton-dependent Cytokinesis Kinase Activity Regulation Of Protein Catabolic Process Protein K11-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Antibiotic Negative Regulation Of Signal Transduction By P53 Class Mediator	Chromatin Remodeling Structural Constituent Of Chromatin Cysteine-type Deubiquitinase Activity Protein Deubiquitination Nucleosome Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Chromatin Organization Post-translational Protein Modification Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Deubiquitinase Activity Cyclin Binding Nucleus Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleoplasm Positive Regulation Of Fibroblast Proliferation Cyclin D2-CDK6 Complex Epigenetic Regulation Of Gene Expression Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Protein Heterodimerization Activity Negative Regulation Of Antifungal Innate Immune Response Microprocessor Complex Positive Regulation Of Pre-miRNA Processing Nuclear Body Regulation Of Fibroblast Proliferation Cyclin D2-CDK4 Complex Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Modification Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cell Cycle Phase Transition Target-directed MiRNA Degradation Elongin Complex Peptidase Activity Protein K27-linked Deubiquitination Protein-RNA Adaptor Activity Cellular Response To Ionomycin Gliogenesis Negative Regulation Of Monocyte Differentiation Cell Dedifferentiation Heterochromatin Formation DeNEDDylase Activity
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