PJA1 and ATXN3L

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		PJA1	ATXN3L
Gene Name		praja ring finger 1, E3 ubiquitin protein ligase	ataxin 3-like
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Gene Ontology Annotations	Cellular Component	Cytoplasm	Mitochondrial Matrix Mitochondrial Membrane Nuclear Inclusion Body
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	RNA Polymerase II Regulatory Region DNA Binding Histone Deacetylase Activity Ubiquitin-specific Protease Activity Omega Peptidase Activity Ubiquitin Protein Ligase Binding
	Biological Process	Protein Ubiquitination Protein Catabolic Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Misfolded Or Incompletely Synthesized Protein Catabolic Process Protein Deubiquitination Cellular Response To Heat Monoubiquitinated Protein Deubiquitination Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone H3 Deacetylation Cellular Response To Misfolded Protein
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		36 interactors: ASCC2 ATP5C1 ATXN3 ATXN3L EED ESPL1 EZH2 GSR HNRNPL JOSD1 KIF22 MAGED1 MDM2 NDN NDNL2 OTUB1 OTUB2 RIBC2 SPTBN1 STAM STAMBP SUZ12 UBC UBE2D2 UBE2D3 UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP7 USP8 ZNF440	6 interactors: PJA1 RFFL TRIM54 TRIM55 TRIM63 USP28
Entrez ID		64219	92552
HPRD ID		02335	19697
Ensembl ID		ENSG00000181191	ENSG00000123594
Uniprot IDs		Q8NG27	B4DYC7 Q9H3M9
PDB IDs		2L0B	3O65
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Protein Modification By Small Protein Removal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteolysis Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Protein Modification Process Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Catabolic Process Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process DNA Repair Cellular Response To Stress Protein K63-linked Deubiquitination Regulation Of Protein Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Metabolic Process Regulation Of Proteolysis Nucleobase-containing Compound Metabolic Process DNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Modification Cell Cycle Process Metabolic Process Nitrogen Compound Metabolic Process Protein Polyubiquitination Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Chromosome Organization Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Ubiquitination Cell Cycle Cytokinesis Protein Modification By Small Protein Conjugation Chromatin Modification Cellular Response To Oxygen Levels Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated Enzyme Linked Receptor Protein Signaling Pathway	Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Catabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis Cellular Macromolecule Catabolic Process Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Skeletal Muscle Atrophy Striated Muscle Atrophy Muscle Atrophy Negative Regulation Of Execution Phase Of Apoptosis Skeletal Muscle Adaptation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Protein Modification Process Proteolysis Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cellular Response To Dexamethasone Stimulus Regulation Of Fibroblast Migration Response To Dexamethasone Negative Regulation Of Microtubule Depolymerization Protein K48-linked Ubiquitination Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Regulation Of Proteolysis Response To Electrical Stimulus Regulation Of Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Microtubule Polymerization Or Depolymerization Cellular Protein Metabolic Process Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of TOR Signaling Cellular Response To UV
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