PJA1 and GLO1

Number of citations of the paper that reports this interaction (PubMedID 21461837)
0

Data Source:
BioGRID (enzymatic study)

		PJA1	GLO1
Description		praja ring finger ubiquitin ligase 1	glyoxalase I
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GO Annotations	Cellular Component	Cytoplasm	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Lactoylglutathione Lyase Activity Protein Binding Zinc Ion Binding Lyase Activity Metal Ion Binding
	Biological Process	Protein Ubiquitination Protein Catabolic Process	Carbohydrate Metabolic Process Regulation Of Transcription By RNA Polymerase II Glutathione Metabolic Process Methylglyoxal Metabolic Process Osteoclast Differentiation Negative Regulation Of Apoptotic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Pyruvate metabolism
Drugs			Glutathione Indomethacin S-P-Nitrobenzyloxycarbonylglutathione S-(N-hydroxy-N-iodophenylcarbamoyl)glutathione Mercaptoethanol S-benzylglutathione S-Hexylglutathione methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate
Diseases
GWAS		Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)	Blood protein levels ( 30072576) Major depressive disorder ( 29317602) Restless legs syndrome ( 29029846) Tuberculosis susceptibility in HIV infection ( 26942285)
Interacting Genes		63 interacting genes: ABR ASCC2 ATP5F1C ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 DYRK1A EED ELAC1 ESPL1 EZH2 FGF12 GATD3 GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440	5 interacting genes: CEBPA IKBKG MAP3K13 MEOX2 PJA1
Entrez ID		64219	2739
HPRD ID		02335	00730
Ensembl ID		ENSG00000181191	ENSG00000124767
Uniprot IDs		Q8NG27	Q04760 X5DNM4
PDB IDs		2L0B	1BH5 1FRO 1QIN 1QIP 3VW9 3W0T 3W0U 7WSZ 7WT0 7WT1 7WT2
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Deubiquitinase Activity Cysteine-type Peptidase Activity Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Proteolysis Protein Modification Process Peptidase Activity Deubiquitinase Activity Cytosol ATP Binding Pronucleus Ubiquitin Binding Protein K48-linked Deubiquitination Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Chromatin Silencing Complex Protein Polyubiquitination Macromolecule Metabolic Process Facultative Heterochromatin Formation ESC/E(Z) Complex Nucleotide Binding Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Cysteine-type Endopeptidase Activity DNA Repair Regulation Of Proteasomal Protein Catabolic Process Mitotic Cytokinesis Transferase Activity Protein K63-linked Deubiquitination DNA Damage Response Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Hydrolase Activity Protein Modification By Small Protein Conjugation DeNEDDylase Activity Sex Chromatin DNA Metabolic Process Ubiquitin-protein Transferase Activity Cytoskeleton-dependent Cytokinesis Kinase Activity Regulation Of Protein Catabolic Process Protein K11-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Antibiotic Negative Regulation Of Signal Transduction By P53 Class Mediator	Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Homodimerization Activity Response To Vitamin B2 C/EBP Complex Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Branching Morphogenesis Of A Nerve IkappaB Kinase Complex Binding Positive Regulation Of Proteolysis CHOP-C/EBP Complex Intracellular Signaling Cassette Regulation Of Ubiquitin-dependent Protein Catabolic Process White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Somite Specification Regulation Of DNA-binding Transcription Factor Activity Linear Polyubiquitin Binding Regulation Of Branching Morphogenesis Of A Nerve Positive Regulation Of Neuron Maturation Protein Domain Specific Binding Response To Phenylpropanoid IkappaB Kinase Complex Fat Cell Proliferation Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Cell Maturation Regulation Of Neuron Maturation Urea Metabolic Process HMG Box Domain Binding Urea Cycle STAT Family Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Transferrin Receptor Binding Anoikis Response To Lithium Ion Regulation Of DNA-templated Transcription Transcription By RNA Polymerase I Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Interleukin-6-mediated Signaling Pathway Regulation Of RNA Biosynthetic Process Protein Heterodimerization Activity Regulation Of Proteolysis Osteoblast Development Segment Specification Somite Development
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