PJA1 and ELAC1

Number of citations of the paper that reports this interaction (PubMedID 21461837)
0

Data Source:
BioGRID (enzymatic study)

		PJA1	ELAC1
Description		praja ring finger ubiquitin ligase 1	elaC ribonuclease Z 1
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GO Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nuclease Activity Endonuclease Activity TRNA-specific Ribonuclease Activity Hydrolase Activity RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism 3'-tRNA Processing Endoribonuclease Activity Metal Ion Binding
	Biological Process	Protein Ubiquitination Protein Catabolic Process	TRNA 3'-terminal CCA Addition TRNA Processing TRNA 3'-end Processing Rescue Of Stalled Ribosome
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)	Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Oligoclonal band status in multiple sclerosis ( 25616667)
Interacting Genes		63 interacting genes: ABR ASCC2 ATP5F1C ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 DYRK1A EED ELAC1 ESPL1 EZH2 FGF12 GATD3 GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440	3 interacting genes: MIR200C MIR25 PJA1
Entrez ID		64219	55520
HPRD ID		02335	16275
Ensembl ID		ENSG00000181191	ENSG00000141642
Uniprot IDs		Q8NG27	Q9H777
PDB IDs		2L0B	3ZWF
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Deubiquitinase Activity Cysteine-type Peptidase Activity Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Proteolysis Protein Modification Process Peptidase Activity Deubiquitinase Activity Cytosol ATP Binding Pronucleus Ubiquitin Binding Protein K48-linked Deubiquitination Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Chromatin Silencing Complex Protein Polyubiquitination Macromolecule Metabolic Process Facultative Heterochromatin Formation ESC/E(Z) Complex Nucleotide Binding Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Cysteine-type Endopeptidase Activity DNA Repair Regulation Of Proteasomal Protein Catabolic Process Mitotic Cytokinesis Transferase Activity Protein K63-linked Deubiquitination DNA Damage Response Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Hydrolase Activity Protein Modification By Small Protein Conjugation DeNEDDylase Activity Sex Chromatin DNA Metabolic Process Ubiquitin-protein Transferase Activity Cytoskeleton-dependent Cytokinesis Kinase Activity Regulation Of Protein Catabolic Process Protein K11-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Antibiotic Negative Regulation Of Signal Transduction By P53 Class Mediator	MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Mesodermal Cell Differentiation Negative Regulation Of Interleukin-33 Production Regulation Of Muscle System Process Negative Regulation Of Calcium Ion Import Across Plasma Membrane Centriolar Subdistal Appendage Microtubule Anchoring At Centrosome Microtubule Anchoring At Microtubule Organizing Center Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Mesodermal Cell Differentiation Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Endothelial Cell Differentiation Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Microtubule Anchoring Negative Regulation Of Cardiac Muscle Tissue Growth Regulation Of System Process Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Post-transcriptional Regulation Of Gene Expression
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