PJA1 and ZNF440

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		PJA1	ZNF440
Gene Name		praja ring finger 1, E3 ubiquitin protein ligase	zinc finger protein 440
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	DNA Binding Metal Ion Binding
	Biological Process	Protein Ubiquitination Protein Catabolic Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Generic Transcription Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		36 interactors: ASCC2 ATP5C1 ATXN3 ATXN3L EED ESPL1 EZH2 GSR HNRNPL JOSD1 KIF22 MAGED1 MDM2 NDN NDNL2 OTUB1 OTUB2 RIBC2 SPTBN1 STAM STAMBP SUZ12 UBC UBE2D2 UBE2D3 UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP7 USP8 ZNF440	12 interactors: KRTAP10-1 KRTAP10-9 KRTAP4-12 MAP4K5 MDFI MID2 MTUS2 NOTCH2NL PAX9 PJA1 TRAF1 XBP1
Entrez ID		64219	126070
HPRD ID		02335	11718
Ensembl ID		ENSG00000181191	ENSG00000171295
Uniprot IDs		Q8NG27	Q8IYI8
PDB IDs		2L0B
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Protein Modification By Small Protein Removal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteolysis Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Protein Modification Process Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Catabolic Process Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process DNA Repair Cellular Response To Stress Protein K63-linked Deubiquitination Regulation Of Protein Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Metabolic Process Regulation Of Proteolysis Nucleobase-containing Compound Metabolic Process DNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Modification Cell Cycle Process Metabolic Process Nitrogen Compound Metabolic Process Protein Polyubiquitination Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Chromosome Organization Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Ubiquitination Cell Cycle Cytokinesis Protein Modification By Small Protein Conjugation Chromatin Modification Cellular Response To Oxygen Levels Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated Enzyme Linked Receptor Protein Signaling Pathway	Activation Of JUN Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Negative Regulation Of RNA Biosynthetic Process Regulation Of JUN Kinase Activity JNK Cascade Positive Regulation Of Lactation Positive Regulation Of Plasma Cell Differentiation Serotonin Secretion, Neurotransmission Epithelial Cell Maturation Involved In Salivary Gland Development Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Protein Kinase Activity Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Stress-activated MAPK Cascade Positive Regulation Of Transferase Activity Stress-activated Protein Kinase Signaling Cascade Cell Differentiation Involved In Salivary Gland Development Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Signal Transduction Activation Of MAPK Activity Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of JNK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Positive Regulation Of Protein Phosphorylation Regulation Of Protein Import Into Nucleus Regulation Of Protein Kinase Activity Regulation Of Signaling Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Serotonin Secretion Regulation Of Intracellular Signal Transduction Regulation Of Organ Morphogenesis Regulation Of Stress-activated MAPK Cascade Regulation Of Kinase Activity Regulation Of Protein Localization To Nucleus Positive Regulation Of MAP Kinase Activity Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Hepatocyte Proliferation Cellular Response To Fructose Stimulus Positive Regulation Of Interleukin-6 Secretion Positive Regulation Of Phosphorylation MAPK Cascade Cellular Response To Laminar Fluid Shear Stress
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