PJA1 and SPTBN1

Number of citations of the paper that reports this interaction (PMID 16247473)
10

Data Source:
BioGRID (affinity chromatography technology, pull down)

		PJA1	SPTBN1
Gene Name		praja ring finger 1, E3 ubiquitin protein ligase	spectrin, beta, non-erythrocytic 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleolus Cytoplasm Cytosol Spectrin Spectrin-associated Cytoskeleton Axolemma M Band Cuticular Plate Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding Phospholipid Binding Ankyrin Binding Protein Complex Binding Poly(A) RNA Binding
	Biological Process	Protein Ubiquitination Protein Catabolic Process	Mitotic Cytokinesis Plasma Membrane Organization Common-partner SMAD Protein Phosphorylation SMAD Protein Import Into Nucleus Axon Guidance Golgi To Plasma Membrane Protein Transport Actin Filament Capping Membrane Assembly Protein Targeting To Plasma Membrane
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Interaction between L1 and Ankyrins Axon guidance Nephrin interactions L1CAM interactions NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS			Bone mineral density ( 22504420) Bone mineral density (spine) ( 19079262 19801982 18445777) Myopia (pathological) ( 22685421)
Protein-Protein Interactions		36 interactors: ASCC2 ATP5C1 ATXN3 ATXN3L EED ESPL1 EZH2 GSR HNRNPL JOSD1 KIF22 MAGED1 MDM2 NDN NDNL2 OTUB1 OTUB2 RIBC2 SPTBN1 STAM STAMBP SUZ12 UBC UBE2D2 UBE2D3 UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP7 USP8 ZNF440	39 interactors: ACTR1A ANK2 APC ATF7IP CAPN1 CDC5L CEP63 CPNE1 CPNE4 CSNK2A1 CTNNA1 DISC1 EPB41 EPB41L3 GRB2 GRIA2 MAPK14 MEF2C NF2 PACSIN1 PDE4D PJA1 PLCB1 PLEKHA5 PRKACA PYGO1 RINT1 SH3BP5 SMAD3 SMAD4 SMAD9 SNCA SPTAN1 SREBF2 STAT1 TNIK TRAF3IP1 YWHAG ZNF512B
Entrez ID		64219	6711
HPRD ID		02335	01683
Ensembl ID		ENSG00000181191	ENSG00000115306
Uniprot IDs		Q8NG27	B2ZZ89 Q01082
PDB IDs		2L0B	1AA2 1BKR 3EDV
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Protein Modification By Small Protein Removal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteolysis Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Protein Modification Process Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Catabolic Process Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process DNA Repair Cellular Response To Stress Protein K63-linked Deubiquitination Regulation Of Protein Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Metabolic Process Regulation Of Proteolysis Nucleobase-containing Compound Metabolic Process DNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Modification Cell Cycle Process Metabolic Process Nitrogen Compound Metabolic Process Protein Polyubiquitination Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Chromosome Organization Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Ubiquitination Cell Cycle Cytokinesis Protein Modification By Small Protein Conjugation Chromatin Modification Cellular Response To Oxygen Levels Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated Enzyme Linked Receptor Protein Signaling Pathway	Regulation Of Cellular Component Organization System Development Intracellular Signal Transduction Nervous System Development Regulation Of Cellular Localization Cell Differentiation Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation Regulation Of Phosphorylation Regulation Of Signal Transduction Multicellular Organismal Development Anatomical Structure Development Cell-cell Junction Organization Regulation Of Intracellular Transport Developmental Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Protein Phosphorylation Neurogenesis Negative Regulation Of Phosphorylation Apoptotic Process Signaling Anatomical Structure Morphogenesis Negative Regulation Of Cellular Metabolic Process Cell Development Organelle Organization Programmed Cell Death Cell Communication Generation Of Neurons Kidney Development Cell Death Cell Morphogenesis Death Regulation Of Protein Metabolic Process Cell-cell Junction Assembly Epithelium Development Cellular Response To Organonitrogen Compound Renal System Development Cell Activation Organ Development Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Protein Metabolic Process Cell Projection Organization Regulation Of Organelle Organization Positive Regulation Of Metabolic Process G2/M Transition Of Mitotic Cell Cycle Neuron Development
Tagcloud ?			adipocyte analyzing classified cytoskeletal differentially exposed exposure fact fatty insights k18 keratin mediating morphogenesis nicotine obstructive osf3 peroxiredoxin phosphoprotein phosphoproteins phosphoproteomic regeneration semi sixteen smoke sought spectrin spt16 tobacco
Tagcloud (Difference) ?			adipocyte analyzing classified cytoskeletal differentially exposed exposure fact fatty insights k18 keratin mediating morphogenesis nicotine obstructive osf3 peroxiredoxin phosphoprotein phosphoproteins phosphoproteomic regeneration semi sixteen smoke sought spectrin spt16 tobacco
Tagcloud (Intersection) ?