PJA1 and JOSD1

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		PJA1	JOSD1
Gene Name		praja ring finger 1, E3 ubiquitin protein ligase	Josephin domain containing 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	Omega Peptidase Activity
	Biological Process	Protein Ubiquitination Protein Catabolic Process	Proteolysis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		36 interactors: ASCC2 ATP5C1 ATXN3 ATXN3L EED ESPL1 EZH2 GSR HNRNPL JOSD1 KIF22 MAGED1 MDM2 NDN NDNL2 OTUB1 OTUB2 RIBC2 SPTBN1 STAM STAMBP SUZ12 UBC UBE2D2 UBE2D3 UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP7 USP8 ZNF440	20 interactors: KRT31 KRT40 KRTAP10-3 KRTAP10-4 KRTAP10-8 KRTAP5-9 KRTAP9-2 LNX1 MID2 NOTCH2NL PJA1 STUB1 TRAF1 TRIM23 TRIM27 TRIM54 TRIM63 USP15 USP21 USP28
Entrez ID		64219	9929
HPRD ID		02335	08823
Ensembl ID		ENSG00000181191	ENSG00000100221
Uniprot IDs		Q8NG27	Q15040
PDB IDs		2L0B
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Protein Modification By Small Protein Removal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteolysis Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Protein Modification Process Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Catabolic Process Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process DNA Repair Cellular Response To Stress Protein K63-linked Deubiquitination Regulation Of Protein Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Metabolic Process Regulation Of Proteolysis Nucleobase-containing Compound Metabolic Process DNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Modification Cell Cycle Process Metabolic Process Nitrogen Compound Metabolic Process Protein Polyubiquitination Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Chromosome Organization Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Ubiquitination Cell Cycle Cytokinesis Protein Modification By Small Protein Conjugation Chromatin Modification Cellular Response To Oxygen Levels Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated Enzyme Linked Receptor Protein Signaling Pathway	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Deubiquitination Negative Regulation Of Viral Release From Host Cell Catabolic Process Cellular Protein Metabolic Process Protein Modification By Small Protein Removal Histone Deubiquitination Regulation Of Protein Catabolic Process Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Protein K63-linked Ubiquitination Proteolysis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Metabolic Process Regulation Of Proteolysis Regulation Of Viral Transcription Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Viral Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly Negative Regulation Of Interleukin-2 Secretion Histone H2B Conserved C-terminal Lysine Deubiquitination Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Communication Negative Regulation Of Calcium Ion Import Skeletal Muscle Atrophy Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Viral Process Ubiquitin-dependent SMAD Protein Catabolic Process Striated Muscle Atrophy Muscle Atrophy Protein Localization To Microtubule Protein Polyubiquitination
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