PJA1 and UCHL3

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		PJA1	UCHL3
Gene Name		praja ring finger 1, E3 ubiquitin protein ligase	ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity Ubiquitin Binding
	Biological Process	Protein Ubiquitination Protein Catabolic Process	Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Diabetic retinopathy ( 23562823)
Protein-Protein Interactions		36 interactors: ASCC2 ATP5C1 ATXN3 ATXN3L EED ESPL1 EZH2 GSR HNRNPL JOSD1 KIF22 MAGED1 MDM2 NDN NDNL2 OTUB1 OTUB2 RIBC2 SPTBN1 STAM STAMBP SUZ12 UBC UBE2D2 UBE2D3 UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP7 USP8 ZNF440	17 interactors: ATXN7L3 CDH1 HMP19 LONRF1 NEDD8 PJA1 PLA2G2A POGK TRIM27 TRIM54 TRIM55 TRIM63 UBC UBE2S USP15 USP21 USP28
Entrez ID		64219	7347
HPRD ID		02335	04367
Ensembl ID		ENSG00000181191	ENSG00000118939
Uniprot IDs		Q8NG27	P15374
PDB IDs		2L0B	1UCH 1XD3
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Protein Modification By Small Protein Removal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteolysis Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Protein Modification Process Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Catabolic Process Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process DNA Repair Cellular Response To Stress Protein K63-linked Deubiquitination Regulation Of Protein Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Metabolic Process Regulation Of Proteolysis Nucleobase-containing Compound Metabolic Process DNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Modification Cell Cycle Process Metabolic Process Nitrogen Compound Metabolic Process Protein Polyubiquitination Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Chromosome Organization Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Ubiquitination Cell Cycle Cytokinesis Protein Modification By Small Protein Conjugation Chromatin Modification Cellular Response To Oxygen Levels Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated Enzyme Linked Receptor Protein Signaling Pathway	Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Catabolic Process Protein Modification By Small Protein Conjugation Proteolysis Histone Deubiquitination Protein Deubiquitination Protein Modification By Small Protein Removal Cellular Protein Modification Process Protein Ubiquitination Protein Polyubiquitination Regulation Of Protein Catabolic Process Activation Of Anaphase-promoting Complex Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Cellular Protein Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Ubiquitination Protein K11-linked Ubiquitination Transforming Growth Factor Beta Receptor Signaling Pathway DNA Damage Checkpoint Regulation Of Cellular Protein Metabolic Process Protein K63-linked Ubiquitination Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Cell Cycle Checkpoint Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cellular Process Negative Regulation Of Transferase Activity Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Free Ubiquitin Chain Polymerization Negative Regulation Of Interleukin-2 Secretion Histone H2B Conserved C-terminal Lysine Deubiquitination Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?			attempts c2 canine changed chemokine depends eia3 eia4 epo folding gstt3 hours hsp90 hypothetical introduced kit masitinib mast neoplastic pdia3 pro proliferative proteome selenbp1 steroid tardbp transcriptionally transcriptome tumour
Tagcloud (Difference) ?			attempts c2 canine changed chemokine depends eia3 eia4 epo folding gstt3 hours hsp90 hypothetical introduced kit masitinib mast neoplastic pdia3 pro proliferative proteome selenbp1 steroid tardbp transcriptionally transcriptome tumour
Tagcloud (Intersection) ?