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PJA1 and UCHL3
Number of citations of the paper that reports this interaction (PMID
22626734
)
2
Data Source:
BioGRID
(enzymatic study)
PJA1
UCHL3
Gene Name
praja ring finger 1, E3 ubiquitin protein ligase
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Image
Gene Ontology Annotations
Cellular Component
Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Extracellular Vesicular Exosome
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Ubiquitin-specific Protease Activity
Protein Binding
Peptidase Activity
Ubiquitin Binding
Biological Process
Protein Ubiquitination
Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Protein Catabolic Process
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Diabetic retinopathy (
23562823
)
Protein-Protein Interactions
36 interactors:
ASCC2
ATP5C1
ATXN3
ATXN3L
EED
ESPL1
EZH2
GSR
HNRNPL
JOSD1
KIF22
MAGED1
MDM2
NDN
NDNL2
OTUB1
OTUB2
RIBC2
SPTBN1
STAM
STAMBP
SUZ12
UBC
UBE2D2
UBE2D3
UBE2L3
UBE2U
UCHL3
UCHL5
USP20
USP28
USP5
USP51
USP7
USP8
ZNF440
17 interactors:
ATXN7L3
CDH1
HMP19
LONRF1
NEDD8
PJA1
PLA2G2A
POGK
TRIM27
TRIM54
TRIM55
TRIM63
UBC
UBE2S
USP15
USP21
USP28
Entrez ID
64219
7347
HPRD ID
02335
04367
Ensembl ID
ENSG00000181191
ENSG00000118939
Uniprot IDs
Q8NG27
P15374
PDB IDs
2L0B
1UCH
1XD3
Enriched GO Terms of Interacting Partners
?
Protein Deubiquitination
Protein Modification By Small Protein Removal
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Proteolysis
Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Protein K48-linked Deubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Cellular Protein Modification Process
Regulation Of Protein Catabolic Process
Cellular Protein Metabolic Process
Catabolic Process
Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
DNA Repair
Cellular Response To Stress
Protein K63-linked Deubiquitination
Regulation Of Protein Metabolic Process
Cellular Response To DNA Damage Stimulus
Cellular Metabolic Process
Regulation Of Proteolysis
Nucleobase-containing Compound Metabolic Process
DNA Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Histone Modification
Cell Cycle Process
Metabolic Process
Nitrogen Compound Metabolic Process
Protein Polyubiquitination
Regulation Of Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Chromosome Organization
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Protein Ubiquitination
Cell Cycle
Cytokinesis
Protein Modification By Small Protein Conjugation
Chromatin Modification
Cellular Response To Oxygen Levels
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Transcription, DNA-templated
Enzyme Linked Receptor Protein Signaling Pathway
Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Catabolic Process
Protein Modification By Small Protein Conjugation
Proteolysis
Histone Deubiquitination
Protein Deubiquitination
Protein Modification By Small Protein Removal
Cellular Protein Modification Process
Protein Ubiquitination
Protein Polyubiquitination
Regulation Of Protein Catabolic Process
Activation Of Anaphase-promoting Complex Activity
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Cellular Protein Metabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Protein Metabolic Process
Regulation Of Proteolysis
Positive Regulation Of Protein Ubiquitination
Protein K11-linked Ubiquitination
Transforming Growth Factor Beta Receptor Signaling Pathway
DNA Damage Checkpoint
Regulation Of Cellular Protein Metabolic Process
Protein K63-linked Ubiquitination
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Protein Ubiquitination
Regulation Of Protein Metabolic Process
Cell Cycle Checkpoint
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Cellular Process
Negative Regulation Of Transferase Activity
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Free Ubiquitin Chain Polymerization
Negative Regulation Of Interleukin-2 Secretion
Histone H2B Conserved C-terminal Lysine Deubiquitination
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Tagcloud
?
attempts
c2
canine
changed
chemokine
depends
eia3
eia4
epo
folding
gstt3
hours
hsp90
hypothetical
introduced
kit
masitinib
mast
neoplastic
pdia3
pro
proliferative
proteome
selenbp1
steroid
tardbp
transcriptionally
transcriptome
tumour
Tagcloud (Difference)
?
attempts
c2
canine
changed
chemokine
depends
eia3
eia4
epo
folding
gstt3
hours
hsp90
hypothetical
introduced
kit
masitinib
mast
neoplastic
pdia3
pro
proliferative
proteome
selenbp1
steroid
tardbp
transcriptionally
transcriptome
tumour
Tagcloud (Intersection)
?