PJA1 and LRG1

Number of citations of the paper that reports this interaction (PubMedID 21461837)
0

Data Source:
BioGRID (enzymatic study)

		PJA1	LRG1
Description		praja ring finger ubiquitin ligase 1	leucine rich alpha-2-glycoprotein 1
Image
GO Annotations	Cellular Component	Cytoplasm	Extracellular Region Extracellular Space Membrane Specific Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Binding Protein Binding Type I Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Binding
	Biological Process	Protein Ubiquitination Protein Catabolic Process	Positive Regulation Of Endothelial Cell Proliferation Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Response To Bacterium Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Keratinocyte Proliferation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Angiogenesis Brown Fat Cell Differentiation Keratinocyte Migration Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Neutrophil degranulation
Drugs			Copper
Diseases
GWAS		Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		63 interacting genes: ABR ASCC2 ATP5F1C ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 DYRK1A EED ELAC1 ESPL1 EZH2 FGF12 GATD3 GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440	2 interacting genes: FN1 PJA1
Entrez ID		64219	116844
HPRD ID		02335	10056
Ensembl ID		ENSG00000181191	ENSG00000171236
Uniprot IDs		Q8NG27	P02750 Q68CK4
PDB IDs		2L0B	7Q4Q 8H24
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Deubiquitinase Activity Cysteine-type Peptidase Activity Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Proteolysis Protein Modification Process Peptidase Activity Deubiquitinase Activity Cytosol ATP Binding Pronucleus Ubiquitin Binding Protein K48-linked Deubiquitination Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Chromatin Silencing Complex Protein Polyubiquitination Macromolecule Metabolic Process Facultative Heterochromatin Formation ESC/E(Z) Complex Nucleotide Binding Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Cysteine-type Endopeptidase Activity DNA Repair Regulation Of Proteasomal Protein Catabolic Process Mitotic Cytokinesis Transferase Activity Protein K63-linked Deubiquitination DNA Damage Response Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Hydrolase Activity Protein Modification By Small Protein Conjugation DeNEDDylase Activity Sex Chromatin DNA Metabolic Process Ubiquitin-protein Transferase Activity Cytoskeleton-dependent Cytokinesis Kinase Activity Regulation Of Protein Catabolic Process Protein K11-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Antibiotic Negative Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Monocyte Activation Calcium-independent Cell-matrix Adhesion Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Peptidase Activator Activity Blood Coagulation, Fibrin Clot Formation Fibrinogen Complex Neural Crest Cell Migration Involved In Autonomic Nervous System Development Integrin Activation Negative Regulation Of Transforming Growth Factor Beta Production Proteoglycan Binding Protein Activation Cascade Acute-phase Response Cell-substrate Junction Organization Endodermal Cell Differentiation Positive Regulation Of Axon Extension Biological Process Involved In Interaction With Symbiont Response To Muscle Activity Cell-substrate Junction Assembly
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