PJA1 and PFKFB4

Number of citations of the paper that reports this interaction (PubMedID 21461837)
0

Data Source:
BioGRID (enzymatic study)

		PJA1	PFKFB4
Description		praja ring finger ubiquitin ligase 1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Cytosol 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Catalytic Activity 6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity
	Biological Process	Protein Ubiquitination Protein Catabolic Process	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Gluconeogenesis Glycolytic Process Carbohydrate Phosphorylation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Drugs			Phosphoaminophosphonic Acid-Adenylate Ester Fructose-6-phosphate
Diseases
GWAS		Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)	Bitter beverage consumption ( 31046077) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Mental health study participation (completed survey) ( 31263887) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 25082827 28067908) Waist-hip index ( 34021172)
Interacting Genes		63 interacting genes: ABR ASCC2 ATP5F1C ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 DYRK1A EED ELAC1 ESPL1 EZH2 FGF12 GATD3 GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440	11 interacting genes: CCDC102B CDC23 CSNK2B FBXL7 FBXO28 GADD45A GSK3B LRR1 PJA1 THOC3 YBX1
Entrez ID		64219	5210
HPRD ID		02335	05613
Ensembl ID		ENSG00000181191	ENSG00000114268
Uniprot IDs		Q8NG27	B7Z5C3 Q16877 Q5XLC3 Q66S35
PDB IDs		2L0B
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Deubiquitinase Activity Cysteine-type Peptidase Activity Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Proteolysis Protein Modification Process Peptidase Activity Deubiquitinase Activity Cytosol ATP Binding Pronucleus Ubiquitin Binding Protein K48-linked Deubiquitination Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Chromatin Silencing Complex Protein Polyubiquitination Macromolecule Metabolic Process Facultative Heterochromatin Formation ESC/E(Z) Complex Nucleotide Binding Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Cysteine-type Endopeptidase Activity DNA Repair Regulation Of Proteasomal Protein Catabolic Process Mitotic Cytokinesis Transferase Activity Protein K63-linked Deubiquitination DNA Damage Response Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Hydrolase Activity Protein Modification By Small Protein Conjugation DeNEDDylase Activity Sex Chromatin DNA Metabolic Process Ubiquitin-protein Transferase Activity Cytoskeleton-dependent Cytokinesis Kinase Activity Regulation Of Protein Catabolic Process Protein K11-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Antibiotic Negative Regulation Of Signal Transduction By P53 Class Mediator	Protein Modification Process Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Protein Ubiquitination Mitotic Cell Cycle Phase Transition Post-translational Protein Modification Cell Cycle Phase Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Protein Metabolic Process Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Anchoring At Centrosome Protein Polyubiquitination Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Cell Migration Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Locomotion Negative Regulation Of Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body MiRNA Transport Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of TORC2 Signaling Negative Regulation Of Dopaminergic Neuron Differentiation Regulation Of Glycogen (starch) Synthase Activity C5-methylcytidine-containing RNA Reader Activity Negative Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Proteolysis Negative Regulation Of Viral Life Cycle Release From Viral Latency Viral Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cilium Macromolecule Catabolic Process Proteasomal Protein Catabolic Process TRNA Transport Histone Pre-mRNA 3'end Processing Complex
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