CD4 and KCNAB2

Number of citations of the paper that reports this interaction (PubMedID 12893943)
0

Data Source:
HPRD (in vitro)

		CD4	KCNAB2
Description		CD4 molecule	potassium voltage-gated channel subfamily A regulatory beta subunit 2
Image
GO Annotations	Cellular Component	Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Clathrin-coated Endocytic Vesicle Membrane T Cell Receptor Complex Membrane Raft	Cytoplasm Cytosol Cytoskeleton Microtubule Plasma Membrane Voltage-gated Potassium Channel Complex Cytoplasmic Side Of Plasma Membrane Membrane Axon Specific Granule Membrane Cell Projection Neuron Projection Juxtaparanode Region Of Axon Synapse Tertiary Granule Membrane Pinceau Fiber
	Molecular Function	Virus Receptor Activity Transmembrane Signaling Receptor Activity Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Zinc Ion Binding Lipid Binding Coreceptor Activity Immunoglobulin Binding Enzyme Binding Protein Kinase Binding MHC Class II Protein Complex Binding Signaling Receptor Activity Interleukin-16 Binding Interleukin-16 Receptor Activity MHC Class II Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Tyrosine Kinase Binding	Voltage-gated Potassium Channel Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Potassium Channel Regulator Activity Oxidoreductase Activity Transmembrane Transporter Binding Methylglyoxal Reductase (NADPH) (acetol Producing) Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Adaptive Immune Response Immune System Process Positive Regulation Of Immune System Process Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Calcium Ion Transport Into Cytosol Calcium-mediated Signaling T Cell Differentiation Macrophage Differentiation Response To Estradiol Maintenance Of Protein Location In Cell Positive Regulation Of Interleukin-2 Production Response To Vitamin D Positive Regulation Of Kinase Activity Helper T Cell Enhancement Of Adaptive Immune Response Interleukin-15-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation T Cell Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade T Cell Selection Response To Ethanol Positive Regulation Of Monocyte Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of Viral Entry Into Host Cell Symbiont Entry Into Host Cell Defense Response To Gram-negative Bacterium Positive Regulation Of Calcium-mediated Signaling Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Positive Regulation Of Multicellular Organismal Process Regulation Of Calcium Ion Transport Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Response To Methamphetamine Hydrochloride Cellular Response To Ionomycin	Monoatomic Ion Transport Potassium Ion Transport Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Protein Localization To Cell Surface
Pathways		Alpha-defensins Nef Mediated CD4 Down-regulation Binding and entry of HIV virion Vpu mediated degradation of CD4 Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules Co-inhibition by PD-1 Other interleukin signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Voltage gated Potassium channels Neutrophil degranulation
Drugs		Antithymocyte immunoglobulin (rabbit) Clenoliximab Ibalizumab	Enflurane Promethazine Miconazole
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Response to Vitamin E supplementation ( 22437554)	Metabolite levels ( 23823483)
Interacting Genes		39 interacting genes: ABCB1 ADORA2A ADRB2 CCR5 CD2 CD28 CD38 CD44 CD5 CD53 CD82 CTSD CXCL12 CXCR4 DPP4 FCGR3A HLA-DPA1 HLA-DQA2 HLA-DQB1 IL16 IL2RA INPPL1 KCNAB2 LAT LCK LGALS1 MAPK14 MARCHF4 PI4KA PIK3R1 PIP PTPRC SELL SIVA1 SPG21 TFRC TNFRSF10A UBL7 UNC119	10 interacting genes: ATXN1 CD4 CEBPA KCNA2 LCOR NEDD4 NEDD4L SLC39A1 SLC39A2 SQSTM1
Entrez ID		920	8514
HPRD ID		01740	03090
Ensembl ID		ENSG00000010610	ENSG00000069424
Uniprot IDs		A0A4Y5UGE4 B0AZV7 B4DT49 P01730	B2R776 Q13303
PDB IDs		1CDH 1CDI 1CDJ 1CDU 1CDY 1G9M 1G9N 1GC1 1JL4 1Q68 1RZJ 1RZK 1WBR 1WIO 1WIP 1WIQ 2B4C 2JKR 2JKT 2KLU 2NXY 2NXZ 2NY0 2NY1 2NY2 2NY3 2NY4 2NY5 2NY6 2QAD 3B71 3CD4 3J70 3JCB 3JCC 3JWD 3JWO 3LQA 3O2D 3S4S 3S5L 3T0E 4H8W 4JM2 4P9H 4Q6I 4R2G 4R4H 4RQS 5A7X 5A8H 5CAY 5THR 5U1F 5VN3 6CM3 6EDU 6L1Y 6MEO 6MET 6OPN 6OPO 6OPP 6OPQ 6QH6 6QH7 6U0L 6U0N 6URI 6X5B 6X5C 7T0O 7T0R 7TXD 8D5C 8FYI 8FYJ 8W90 8Z7N	1ZSX 7EJ1 7EJ2 7WF3 7WF4
Enriched GO Terms of Interacting Partners?		Immune System Process Regulation Of Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Cell Adhesion Positive Regulation Of Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Antigen Receptor-mediated Signaling Pathway Plasma Membrane Cell Activation External Side Of Plasma Membrane Lymphocyte Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Signal Transduction Leukocyte Activation Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response T Cell Activation Immune Response-regulating Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation T Cell Costimulation Immune Response-activating Signaling Pathway Positive Regulation Of Leukocyte Proliferation Defense Response Immune Response Activation Of Immune Response Membrane Raft Distribution Clathrin-coated Endocytic Vesicle Membrane Apoptotic Signaling Pathway Membrane Raft Localization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Leukocyte Migration Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II MHC Class II Receptor Activity	Fat Cell Proliferation Sodium Channel Inhibitor Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Channel Inhibitor Activity Metal Ion Transport Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Monoatomic Cation Transport Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Metal Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transporter Activity Positive Regulation Of Protein Metabolic Process DNA-templated Transcription Zinc Ion Transport Zinc Ion Transmembrane Transport Regulation Of Membrane Potential Ionotropic Glutamate Receptor Binding Negative Regulation Of Potassium Ion Transport Monoatomic Ion Transport Regulation Of Protein Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Neuromuscular Junction Development Positive Regulation Of Protein Catabolic Process Macrophage Differentiation Positive Regulation Of Catabolic Process Receptor Metabolic Process Interleukin-16 Binding Regulation Of Biological Quality Interleukin-16 Receptor Activity Helper T Cell Enhancement Of Adaptive Immune Response Regulation Of Monoatomic Cation Transmembrane Transport RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Protein Targeting To Vacuole Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process Protein Polyubiquitination Regulation Of Dendrite Morphogenesis Establishment Of Protein Localization To Vacuole Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Transcription By RNA Polymerase II Inorganic Ion Transmembrane Transport Energy Homeostasis Negative Regulation Of Cation Transmembrane Transport Regulation Of Sodium Ion Transport Receptor Internalization Response To Methamphetamine Hydrochloride
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