CD4 and PIP

Number of citations of the paper that reports this interaction (PubMedID 10820003)
0

Data Source:
HPRD (in vitro, in vivo)

		CD4	PIP
Description		CD4 molecule	prolactin induced protein
Image
GO Annotations	Cellular Component	Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Clathrin-coated Endocytic Vesicle Membrane T Cell Receptor Complex Membrane Raft	Extracellular Region Extracellular Space Nucleus Extracellular Exosome
	Molecular Function	Virus Receptor Activity Transmembrane Signaling Receptor Activity Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Zinc Ion Binding Lipid Binding Coreceptor Activity Immunoglobulin Binding Enzyme Binding Protein Kinase Binding MHC Class II Protein Complex Binding Signaling Receptor Activity Interleukin-16 Binding Interleukin-16 Receptor Activity MHC Class II Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Tyrosine Kinase Binding	Actin Binding Aspartic-type Endopeptidase Activity Protein Binding IgG Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Adaptive Immune Response Immune System Process Positive Regulation Of Immune System Process Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Calcium Ion Transport Into Cytosol Calcium-mediated Signaling T Cell Differentiation Macrophage Differentiation Response To Estradiol Maintenance Of Protein Location In Cell Positive Regulation Of Interleukin-2 Production Response To Vitamin D Positive Regulation Of Kinase Activity Helper T Cell Enhancement Of Adaptive Immune Response Interleukin-15-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation T Cell Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade T Cell Selection Response To Ethanol Positive Regulation Of Monocyte Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of Viral Entry Into Host Cell Symbiont Entry Into Host Cell Defense Response To Gram-negative Bacterium Positive Regulation Of Calcium-mediated Signaling Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Positive Regulation Of Multicellular Organismal Process Regulation Of Calcium Ion Transport Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Response To Methamphetamine Hydrochloride Cellular Response To Ionomycin	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Regulation Of Immune System Process Proteolysis Positive Regulation Of Gene Expression Negative Regulation Of T Cell Apoptotic Process
Pathways		Alpha-defensins Nef Mediated CD4 Down-regulation Binding and entry of HIV virion Vpu mediated degradation of CD4 Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules Co-inhibition by PD-1 Other interleukin signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Miscellaneous transport and binding events
Drugs		Antithymocyte immunoglobulin (rabbit) Clenoliximab Ibalizumab
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Response to Vitamin E supplementation ( 22437554)	Blood protein levels ( 30072576) Cancer ( 29299148) Dermatomyositis ( 27153935)
Interacting Genes		39 interacting genes: ABCB1 ADORA2A ADRB2 CCR5 CD2 CD28 CD38 CD44 CD5 CD53 CD82 CTSD CXCL12 CXCR4 DPP4 FCGR3A HLA-DPA1 HLA-DQA2 HLA-DQB1 IL16 IL2RA INPPL1 KCNAB2 LAT LCK LGALS1 MAPK14 MARCHF4 PI4KA PIK3R1 PIP PTPRC SELL SIVA1 SPG21 TFRC TNFRSF10A UBL7 UNC119	4 interacting genes: CD4 NEIL3 SPI1 USP7
Entrez ID		920	5304
HPRD ID		01740	07179
Ensembl ID		ENSG00000010610	ENSG00000159763
Uniprot IDs		A0A4Y5UGE4 B0AZV7 B4DT49 P01730	P12273
PDB IDs		1CDH 1CDI 1CDJ 1CDU 1CDY 1G9M 1G9N 1GC1 1JL4 1Q68 1RZJ 1RZK 1WBR 1WIO 1WIP 1WIQ 2B4C 2JKR 2JKT 2KLU 2NXY 2NXZ 2NY0 2NY1 2NY2 2NY3 2NY4 2NY5 2NY6 2QAD 3B71 3CD4 3J70 3JCB 3JCC 3JWD 3JWO 3LQA 3O2D 3S4S 3S5L 3T0E 4H8W 4JM2 4P9H 4Q6I 4R2G 4R4H 4RQS 5A7X 5A8H 5CAY 5THR 5U1F 5VN3 6CM3 6EDU 6L1Y 6MEO 6MET 6OPN 6OPO 6OPP 6OPQ 6QH6 6QH7 6U0L 6U0N 6URI 6X5B 6X5C 7T0O 7T0R 7TXD 8D5C 8FYI 8FYJ 8W90 8Z7N	3ES6
Enriched GO Terms of Interacting Partners?		Immune System Process Regulation Of Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Cell Adhesion Positive Regulation Of Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Antigen Receptor-mediated Signaling Pathway Plasma Membrane Cell Activation External Side Of Plasma Membrane Lymphocyte Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Signal Transduction Leukocyte Activation Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response T Cell Activation Immune Response-regulating Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation T Cell Costimulation Immune Response-activating Signaling Pathway Positive Regulation Of Leukocyte Proliferation Defense Response Immune Response Activation Of Immune Response Membrane Raft Distribution Clathrin-coated Endocytic Vesicle Membrane Apoptotic Signaling Pathway Membrane Raft Localization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Leukocyte Migration Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II MHC Class II Receptor Activity	Regulation Of Myeloid Cell Differentiation Response To Ethanol Macrophage Differentiation Immunoglobulin Binding Response To Methamphetamine Hydrochloride MHC Class II Protein Binding Response To Stress Interleukin-16 Binding Positive Regulation Of Leukocyte Differentiation Lymphocyte Differentiation Interleukin-16 Receptor Activity Cellular Response To Ionomycin Myeloid Cell Differentiation Helper T Cell Enhancement Of Adaptive Immune Response Myeloid Leukocyte Differentiation Acetylcholine Receptor Inhibitor Activity Regulation Of Myeloid Progenitor Cell Differentiation Regulation Of Neutrophil Degranulation Positive Regulation Of Microglial Cell Mediated Cytotoxicity Pericyte Cell Differentiation Endothelial To Hematopoietic Transition Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Apoptotic Process Involved In Blood Vessel Morphogenesis Positive Regulation Of Antifungal Innate Immune Response Pro-T Cell Differentiation NFAT Protein Binding Oncogene-induced Cell Senescence Negative Regulation Of Neutrophil Degranulation Negative Regulation Of MHC Class II Biosynthetic Process Follicular B Cell Differentiation Negative Regulation Of Protein Localization To Chromatin Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Retrograde Transport, Endosome To Golgi Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Depurination MCM Complex Binding Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Response To Alcohol Delamination Negative Regulation Of Adipose Tissue Development Bubble DNA Binding Regulation Of Protein Localization To Chromatin TRAIL-activated Apoptotic Signaling Pathway Germinal Center B Cell Differentiation Epigenetic Regulation Of Gene Expression Monoubiquitinated Protein Deubiquitination Cellular Response To Ether Interleukin-15-mediated Signaling Pathway
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