CD4 and TNFRSF10A

Number of citations of the paper that reports this interaction (PMID 7650480)
4

Data Source:
HPRD (in vivo)

		CD4	TNFRSF10A
Gene Name		CD4 molecule	tumor necrosis factor receptor superfamily, member 10a
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Membrane Raft	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Glycoprotein Binding Receptor Activity Transmembrane Signaling Receptor Activity Extracellular Matrix Structural Constituent Protein Binding Zinc Ion Binding Coreceptor Activity Enzyme Binding Protein Kinase Binding MHC Class II Protein Binding Protein Homodimerization Activity	Protease Binding Receptor Activity Death Receptor Activity Protein Binding Transcription Factor Binding TRAIL Binding
	Biological Process	Cytokine Production Induction By Virus Of Host Cell-cell Fusion Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Viral Process T Cell Differentiation Entry Into Host Cell T Cell Costimulation Maintenance Of Protein Location In Cell T Cell Selection Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Protein Palmitoleylation Positive Regulation Of Protein Kinase Activity Regulation Of Defense Response To Virus By Virus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Regulation Of T Cell Activation	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors TRAIL-activated Apoptotic Signaling Pathway Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Vpu mediated degradation of CD4 Downstream TCR signaling Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Costimulation by the CD28 family Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Early Phase of HIV Life Cycle HIV Life Cycle TCR signaling Alpha-defensins PD-1 signaling Defensins Phosphorylation of CD3 and TCR zeta chains Nef Mediated CD4 Down-regulation Binding and entry of HIV virion Innate Immune System Adaptive Immune System	Regulation by c-FLIP Death Receptor Signalling TRAIL signaling Dimerization of procaspase-8 Caspase-8 activation by cleavage Programmed Cell Death Extrinsic Pathway
Drugs
Diseases
GWAS		Response to Vitamin E supplementation ( 22437554)	Age-related macular degeneration ( 21909106 23455636) Attention deficit hyperactivity disorder ( 20732625)
Protein-Protein Interactions		38 interactors: ABCB1 ADRB2 CCR5 CD2 CD28 CD38 CD44 CD5 CD53 CD82 CTSD CXCL12 CXCR4 DPP4 FCGR3A HLA-DPA1 HLA-DQA2 HLA-DQB1 IL16 IL2RA INPPL1 KCNAB2 LAT LCK LGALS1 MAPK14 MARCH4 PI4KA PIK3R1 PIP PTPRC SELL SIVA1 SPG21 TFRC TNFRSF10A UBL7 UNC119	15 interactors: BCL10 BTK CASP8 CD4 COL2A1 DAP3 FADD MADD MOAP1 RASSF1 RIPK1 TNFRSF10B TNFRSF10D TNFSF10 TRADD
Entrez ID		920	8797
HPRD ID		01740	04679
Ensembl ID		ENSG00000010610
Uniprot IDs		B0AZV7 B4DT49 P01730	O00220
PDB IDs		1CDH 1CDI 1CDJ 1CDU 1CDY 1G9M 1G9N 1GC1 1JL4 1OPN 1OPT 1OPW 1Q68 1RZJ 1RZK 1WBR 1WIO 1WIP 1WIQ 2B4C 2JKR 2JKT 2KLU 2NXY 2NXZ 2NY0 2NY1 2NY2 2NY3 2NY4 2NY5 2NY6 2QAD 3B71 3CD4 3JWD 3JWO 3LQA 3O2D 3S4S 3S5L 3T0E 4JM2
Enriched GO Terms of Interacting Partners?		Immune System Process Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Regulation Of Immune System Process Regulation Of T Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Activation Positive Regulation Of Cell-cell Adhesion T Cell Costimulation Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Stimulus Immune Response-regulating Signaling Pathway T Cell Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune Response Signaling Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Lymphocyte Activation Leukocyte Aggregation Cellular Response To Stimulus Apoptotic Process Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Programmed Cell Death Response To Stress Leukocyte Migration Leukocyte Activation Cell Death Death Cell Activation Defense Response Homeostatic Process T Cell Aggregation T Cell Activation Lymphocyte Aggregation Locomotion Cell Migration Cell Motility Single Organismal Cell-cell Adhesion Cellular Chemical Homeostasis	Regulation Of Extrinsic Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Peptidase Activity Regulation Of Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway Zymogen Activation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Protein Processing Cellular Response To Stimulus Toll-like Receptor Signaling Pathway Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Signaling Cell Communication Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Macrophage Differentiation Regulation Of Signal Transduction Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Catalytic Activity Regulation Of Proteolysis
Tagcloud ?		allergen asthmatics box caat cd18 chemotactic coactivator complexity concert consists dyad exons ga gabp gabpalpha harbor inducible introns lymphocytes mast motifs posttranslational pro processed remote share supplementing symmetry tata tightly	aa activator atm atmmutated b bax cdkn1a cll combinations elicit harboring hot lymphocytic maintained mdm2 next notch1 notch1mutated notch1mutations notch2 nutlin showing spot subgroup subset surprisingly tp53 tp53mutated
Tagcloud (Difference) ?		allergen asthmatics box caat cd18 chemotactic coactivator complexity concert consists dyad exons ga gabp gabpalpha harbor inducible introns lymphocytes mast motifs posttranslational pro processed remote share supplementing symmetry tata tightly	aa activator atm atmmutated b bax cdkn1a cll combinations elicit harboring hot lymphocytic maintained mdm2 next notch1 notch1mutated notch1mutations notch2 nutlin showing spot subgroup subset surprisingly tp53 tp53mutated
Tagcloud (Intersection) ?