CD4 and FCGR3A

Number of citations of the paper that reports this interaction (PubMedID 11756173)
0

Data Source:
HPRD (in vitro)

		CD4	FCGR3A
Description		CD4 molecule	Fc gamma receptor IIIa
Image
GO Annotations	Cellular Component	Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Clathrin-coated Endocytic Vesicle Membrane T Cell Receptor Complex Membrane Raft	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Fc-gamma Receptor III Complex Extracellular Exosome
	Molecular Function	Virus Receptor Activity Transmembrane Signaling Receptor Activity Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Zinc Ion Binding Lipid Binding Coreceptor Activity Immunoglobulin Binding Enzyme Binding Protein Kinase Binding MHC Class II Protein Complex Binding Signaling Receptor Activity Interleukin-16 Binding Interleukin-16 Receptor Activity MHC Class II Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Tyrosine Kinase Binding	Protein Binding IgG Receptor Activity Low-affinity IgG Receptor Activity IgG Binding Immune Receptor Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Adaptive Immune Response Immune System Process Positive Regulation Of Immune System Process Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Calcium Ion Transport Into Cytosol Calcium-mediated Signaling T Cell Differentiation Macrophage Differentiation Response To Estradiol Maintenance Of Protein Location In Cell Positive Regulation Of Interleukin-2 Production Response To Vitamin D Positive Regulation Of Kinase Activity Helper T Cell Enhancement Of Adaptive Immune Response Interleukin-15-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation T Cell Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade T Cell Selection Response To Ethanol Positive Regulation Of Monocyte Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of Viral Entry Into Host Cell Symbiont Entry Into Host Cell Defense Response To Gram-negative Bacterium Positive Regulation Of Calcium-mediated Signaling Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Positive Regulation Of Multicellular Organismal Process Regulation Of Calcium Ion Transport Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Response To Methamphetamine Hydrochloride Cellular Response To Ionomycin	Antibody-dependent Cellular Cytotoxicity T Cell Mediated Cytotoxicity Immune System Process Immune Response Cell Surface Receptor Signaling Pathway Protein Import Calcium-mediated Signaling Natural Killer Cell Activation Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Proliferation Fc-gamma Receptor Signaling Pathway Macrophage Activation Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Degranulation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Transmembrane Transport Granzyme-mediated Programmed Cell Death Signaling Pathway
Pathways		Alpha-defensins Nef Mediated CD4 Down-regulation Binding and entry of HIV virion Vpu mediated degradation of CD4 Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules Co-inhibition by PD-1 Other interleukin signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis
Drugs		Antithymocyte immunoglobulin (rabbit) Clenoliximab Ibalizumab	Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Alemtuzumab Alefacept Palivizumab Daclizumab Bevacizumab Catumaxomab Sarilumab Benralizumab Amivantamab
Diseases			NK cell defects, including the following disease: CD16 deficiency Systemic lupus erythematosus
GWAS		Bone mineral density (hip) ( 30172743) Response to Vitamin E supplementation ( 22437554)	Alanine aminotransferase levels ( 33547301) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Birth weight ( 31043758) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Hematocrit ( 32888494) Hemoglobin ( 32888494) Inflammatory bowel disease ( 23128233 28067908) Monocyte percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Systemic lupus erythematosus ( 28714469) Takayasu arteritis ( 23830517 30498034) Type 1 diabetes (age at diagnosis) ( 33179336) Ulcerative colitis ( 28067908)
Interacting Genes		39 interacting genes: ABCB1 ADORA2A ADRB2 CCR5 CD2 CD28 CD38 CD44 CD5 CD53 CD82 CTSD CXCL12 CXCR4 DPP4 FCGR3A HLA-DPA1 HLA-DQA2 HLA-DQB1 IL16 IL2RA INPPL1 KCNAB2 LAT LCK LGALS1 MAPK14 MARCHF4 PI4KA PIK3R1 PIP PTPRC SELL SIVA1 SPG21 TFRC TNFRSF10A UBL7 UNC119	20 interacting genes: APCS APP CD247 CD38 CD4 CFTR FCER1G FCGR1A GP6 IGHG1 LCK LXN PRKCA PRKCI PTPRC S100A4 SHC1 SYK ZAP70 ZBTB25
Entrez ID		920	2214
HPRD ID		01740	00903
Ensembl ID		ENSG00000010610	ENSG00000203747
Uniprot IDs		A0A4Y5UGE4 B0AZV7 B4DT49 P01730	H0Y755 P08637
PDB IDs		1CDH 1CDI 1CDJ 1CDU 1CDY 1G9M 1G9N 1GC1 1JL4 1Q68 1RZJ 1RZK 1WBR 1WIO 1WIP 1WIQ 2B4C 2JKR 2JKT 2KLU 2NXY 2NXZ 2NY0 2NY1 2NY2 2NY3 2NY4 2NY5 2NY6 2QAD 3B71 3CD4 3J70 3JCB 3JCC 3JWD 3JWO 3LQA 3O2D 3S4S 3S5L 3T0E 4H8W 4JM2 4P9H 4Q6I 4R2G 4R4H 4RQS 5A7X 5A8H 5CAY 5THR 5U1F 5VN3 6CM3 6EDU 6L1Y 6MEO 6MET 6OPN 6OPO 6OPP 6OPQ 6QH6 6QH7 6U0L 6U0N 6URI 6X5B 6X5C 7T0O 7T0R 7TXD 8D5C 8FYI 8FYJ 8W90 8Z7N	3AY4 3SGJ 3SGK 3WN5 5BW7 5D6D 5ML9 5MN2 5VU0 5XJE 5XJF 5YC5 7SEG 7URU
Enriched GO Terms of Interacting Partners?		Immune System Process Regulation Of Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Cell Adhesion Positive Regulation Of Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Antigen Receptor-mediated Signaling Pathway Plasma Membrane Cell Activation External Side Of Plasma Membrane Lymphocyte Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Signal Transduction Leukocyte Activation Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response T Cell Activation Immune Response-regulating Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation T Cell Costimulation Immune Response-activating Signaling Pathway Positive Regulation Of Leukocyte Proliferation Defense Response Immune Response Activation Of Immune Response Membrane Raft Distribution Clathrin-coated Endocytic Vesicle Membrane Apoptotic Signaling Pathway Membrane Raft Localization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Leukocyte Migration Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II MHC Class II Receptor Activity	Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Immune Response Fc Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Transport Regulation Of Cell Activation Adaptive Immune Response Cell Activation Positive Regulation Of Immune Response Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Complex Gamma-delta T Cell Activation Leukocyte Activation Activation Of Immune Response T Cell Differentiation Immune System Process Positive Regulation Of Endocytosis Positive Regulation Of MAPK Cascade Lymphocyte Activation T Cell Selection Defense Response To Bacterium T Cell Activation Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Cytokine Production Positive Regulation Of Multicellular Organismal Process Regulation Of Calcium-mediated Signaling Antibody-dependent Cellular Cytotoxicity Positive Regulation Of Leukocyte Differentiation Defense Response Regulation Of Phagocytosis Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of Vesicle-mediated Transport Response To Stress Immunoglobulin Mediated Immune Response Membrane Raft Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cytokine Production Plasma Membrane
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