CD4 and CD28

Number of citations of the paper that reports this interaction (PMID 7539755)
7

Data Source:
HPRD (in vitro)

		CD4	CD28
Gene Name		CD4 molecule	CD28 molecule
Image
Gene Ontology Annotations	Cellular Component	Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Membrane Raft	Immunological Synapse Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Glycoprotein Binding Receptor Activity Transmembrane Signaling Receptor Activity Extracellular Matrix Structural Constituent Protein Binding Zinc Ion Binding Coreceptor Activity Enzyme Binding Protein Kinase Binding MHC Class II Protein Binding Protein Homodimerization Activity	Protease Binding SH3/SH2 Adaptor Activity Protein Binding Coreceptor Activity Identical Protein Binding
	Biological Process	Cytokine Production Induction By Virus Of Host Cell-cell Fusion Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Viral Process T Cell Differentiation Entry Into Host Cell T Cell Costimulation Maintenance Of Protein Location In Cell T Cell Selection Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Protein Palmitoleylation Positive Regulation Of Protein Kinase Activity Regulation Of Defense Response To Virus By Virus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Regulation Of T Cell Activation	Positive Regulation Of Inflammatory Response To Antigenic Stimulus Humoral Immune Response Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Cytokine Biosynthetic Process Positive Regulation Of T Cell Proliferation Negative Thymic T Cell Selection Regulatory T Cell Differentiation Positive Regulation Of Viral Genome Replication Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Positive Regulation Of Translation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Alpha-beta T Cell Proliferation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Defense Response To Virus By Virus T Cell Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway
Pathways		Vpu mediated degradation of CD4 Downstream TCR signaling Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Costimulation by the CD28 family Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Early Phase of HIV Life Cycle HIV Life Cycle TCR signaling Alpha-defensins PD-1 signaling Defensins Phosphorylation of CD3 and TCR zeta chains Nef Mediated CD4 Down-regulation Binding and entry of HIV virion Innate Immune System Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Costimulation by the CD28 family PIP3 activates AKT signaling HIV Infection Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Nef mediated downregulation of CD28 cell surface expression CD28 co-stimulation Host Interactions of HIV factors CD28 dependent PI3K/Akt signaling The role of Nef in HIV-1 replication and disease pathogenesis Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR CD28 dependent Vav1 pathway Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		Response to Vitamin E supplementation ( 22437554)	Celiac disease ( 20190752) Graves' disease ( 21841780)
Protein-Protein Interactions		38 interactors: ABCB1 ADRB2 CCR5 CD2 CD28 CD38 CD44 CD5 CD53 CD82 CTSD CXCL12 CXCR4 DPP4 FCGR3A HLA-DPA1 HLA-DQA2 HLA-DQB1 IL16 IL2RA INPPL1 KCNAB2 LAT LCK LGALS1 MAPK14 MARCH4 PI4KA PIK3R1 PIP PTPRC SELL SIVA1 SPG21 TFRC TNFRSF10A UBL7 UNC119	17 interactors: CD247 CD4 CD80 CD86 DUSP14 GRAP2 GRB2 IL12A ITK LCK LRRC23 NSF PIK3CG PIK3R1 PIK3R2 PLCG1 PTPRC
Entrez ID		920	940
HPRD ID		01740	01727
Ensembl ID		ENSG00000010610	ENSG00000178562
Uniprot IDs		B0AZV7 B4DT49 P01730	B4E0L1 P10747
PDB IDs		1CDH 1CDI 1CDJ 1CDU 1CDY 1G9M 1G9N 1GC1 1JL4 1OPN 1OPT 1OPW 1Q68 1RZJ 1RZK 1WBR 1WIO 1WIP 1WIQ 2B4C 2JKR 2JKT 2KLU 2NXY 2NXZ 2NY0 2NY1 2NY2 2NY3 2NY4 2NY5 2NY6 2QAD 3B71 3CD4 3JWD 3JWO 3LQA 3O2D 3S4S 3S5L 3T0E 4JM2	1YJD
Enriched GO Terms of Interacting Partners?		Immune System Process Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Regulation Of Immune System Process Regulation Of T Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Activation Positive Regulation Of Cell-cell Adhesion T Cell Costimulation Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Stimulus Immune Response-regulating Signaling Pathway T Cell Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune Response Signaling Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Lymphocyte Activation Leukocyte Aggregation Cellular Response To Stimulus Apoptotic Process Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Programmed Cell Death Response To Stress Leukocyte Migration Leukocyte Activation Cell Death Death Cell Activation Defense Response Homeostatic Process T Cell Aggregation T Cell Activation Lymphocyte Aggregation Locomotion Cell Migration Cell Motility Single Organismal Cell-cell Adhesion Cellular Chemical Homeostasis	Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway T Cell Costimulation Positive Regulation Of Cell-cell Adhesion Regulation Of Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Defense Response Innate Immune Response Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Fc-epsilon Receptor Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Cell Adhesion Immune Response Regulation Of Immune System Process Regulation Of Cell Activation Immune System Process Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Phosphorylation Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Activation Regulation Of Phosphorus Metabolic Process T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Activation Leukocyte Aggregation Response To Stress Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Viral Process Positive Regulation Of Signal Transduction
Tagcloud ?		allergen asthmatics box caat cd18 chemotactic coactivator complexity concert consists dyad exons ga gabp gabpalpha harbor inducible introns lymphocytes mast motifs posttranslational pro processed remote share supplementing symmetry tata tightly	accelerated allows augment b7 catalytically cd28re composite concert consistently converge costimulatory element herein ikappab ikk ikkalpha ikkbeta ikks inactive initiated interleukin liberated mitogen presenting proteasome robust tcr transactivation upstream
Tagcloud (Difference) ?		allergen asthmatics box caat cd18 chemotactic coactivator complexity consists dyad exons ga gabp gabpalpha harbor inducible introns lymphocytes mast motifs posttranslational pro processed remote share supplementing symmetry tata tightly	accelerated allows augment b7 catalytically cd28re composite consistently converge costimulatory element herein ikappab ikk ikkalpha ikkbeta ikks inactive initiated interleukin liberated mitogen presenting proteasome robust tcr transactivation upstream
Tagcloud (Intersection) ?		concert