CD4 and CD38

Number of citations of the paper that reports this interaction (PMID 7539755)
7

Data Source:
HPRD (in vitro)

		CD4	CD38
Gene Name		CD4 molecule	CD38 molecule
Image
Gene Ontology Annotations	Cellular Component	Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Membrane Raft	Nucleus Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Glycoprotein Binding Receptor Activity Transmembrane Signaling Receptor Activity Extracellular Matrix Structural Constituent Protein Binding Zinc Ion Binding Coreceptor Activity Enzyme Binding Protein Kinase Binding MHC Class II Protein Binding Protein Homodimerization Activity	NAD+ Nucleosidase Activity Transferase Activity Phosphorus-oxygen Lyase Activity NAD(P)+ Nucleosidase Activity
	Biological Process	Cytokine Production Induction By Virus Of Host Cell-cell Fusion Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Viral Process T Cell Differentiation Entry Into Host Cell T Cell Costimulation Maintenance Of Protein Location In Cell T Cell Selection Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Protein Palmitoleylation Positive Regulation Of Protein Kinase Activity Regulation Of Defense Response To Virus By Virus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Regulation Of T Cell Activation	Response To Hypoxia Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Female Pregnancy Metabolic Process Positive Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Insulin Secretion Response To Estradiol Response To Retinoic Acid Response To Progesterone Response To Hydroperoxide Response To Drug Negative Regulation Of Apoptotic Process Negative Regulation Of Bone Resorption Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasoconstriction B Cell Receptor Signaling Pathway Long Term Synaptic Depression Response To Interleukin-1 Apoptotic Signaling Pathway
Pathways		Vpu mediated degradation of CD4 Downstream TCR signaling Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Costimulation by the CD28 family Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Early Phase of HIV Life Cycle HIV Life Cycle TCR signaling Alpha-defensins PD-1 signaling Defensins Phosphorylation of CD3 and TCR zeta chains Nef Mediated CD4 Down-regulation Binding and entry of HIV virion Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS		Response to Vitamin E supplementation ( 22437554)
Protein-Protein Interactions		38 interactors: ABCB1 ADRB2 CCR5 CD2 CD28 CD38 CD44 CD5 CD53 CD82 CTSD CXCL12 CXCR4 DPP4 FCGR3A HLA-DPA1 HLA-DQA2 HLA-DQB1 IL16 IL2RA INPPL1 KCNAB2 LAT LCK LGALS1 MAPK14 MARCH4 PI4KA PIK3R1 PIP PTPRC SELL SIVA1 SPG21 TFRC TNFRSF10A UBL7 UNC119	6 interactors: CBL CD4 CD9 FCGR3A LCK PECAM1
Entrez ID		920	952
HPRD ID		01740	00116
Ensembl ID		ENSG00000010610
Uniprot IDs		B0AZV7 B4DT49 P01730	P28907
PDB IDs		1CDH 1CDI 1CDJ 1CDU 1CDY 1G9M 1G9N 1GC1 1JL4 1OPN 1OPT 1OPW 1Q68 1RZJ 1RZK 1WBR 1WIO 1WIP 1WIQ 2B4C 2JKR 2JKT 2KLU 2NXY 2NXZ 2NY0 2NY1 2NY2 2NY3 2NY4 2NY5 2NY6 2QAD 3B71 3CD4 3JWD 3JWO 3LQA 3O2D 3S4S 3S5L 3T0E 4JM2	1YH3 1ZVM 2EF1 2HCT 2I65 2I66 2I67 2O3Q 2O3R 2O3S 2O3T 2O3U 2PGJ 2PGL 3DZF 3DZG 3DZH 3DZI 3DZJ 3DZK 3F6Y 3I9M 3I9N 3OFS 3RAJ 3ROK 3ROM 3ROP 3ROQ 3U4H 3U4I 4F45 4F46
Enriched GO Terms of Interacting Partners?		Immune System Process Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Regulation Of Immune System Process Regulation Of T Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Activation Positive Regulation Of Cell-cell Adhesion T Cell Costimulation Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Stimulus Immune Response-regulating Signaling Pathway T Cell Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune Response Signaling Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Lymphocyte Activation Leukocyte Aggregation Cellular Response To Stimulus Apoptotic Process Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Programmed Cell Death Response To Stress Leukocyte Migration Leukocyte Activation Cell Death Death Cell Activation Defense Response Homeostatic Process T Cell Aggregation T Cell Activation Lymphocyte Aggregation Locomotion Cell Migration Cell Motility Single Organismal Cell-cell Adhesion Cellular Chemical Homeostasis	Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Cell Activation Platelet Activation Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Defense Response To Virus By Virus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Cell Adhesion Positive Regulation Of JAK-STAT Cascade Blood Coagulation Positive Regulation Of Signal Transduction Hemostasis Regulation Of Immune System Process Platelet Degranulation Immune Response-regulating Signaling Pathway T Cell Costimulation Regulation Of Cellular Ketone Metabolic Process Regulation Of Defense Response To Virus Regulation Of JAK-STAT Cascade Induction By Virus Of Host Cell-cell Fusion Protein Palmitoleylation Regulation Of Body Fluid Levels Wound Healing T Cell Receptor Signaling Pathway Response To Stress Positive Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Antigen Receptor-mediated Signaling Pathway Diapedesis Positive Regulation Of Protein Phosphorylation T Cell Differentiation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Phosphorylation Immune System Process Regulation Of Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of T Cell Activation
Tagcloud ?		allergen asthmatics box caat cd18 chemotactic coactivator complexity concert consists dyad exons ga gabp gabpalpha harbor inducible introns lymphocytes mast motifs posttranslational pro processed remote share supplementing symmetry tata tightly	alters apl cd18 changing coexpressed confirms develops engineered fuses heterodimerize hl60 leucine lost nb4 pml proline promyelocytic r4 rar rares relapsed relieved repressed retain retains retinoid subclone subclones unrearranged
Tagcloud (Difference) ?		allergen asthmatics box caat chemotactic coactivator complexity concert consists dyad exons ga gabp gabpalpha harbor inducible introns lymphocytes mast motifs posttranslational pro processed remote share supplementing symmetry tata tightly	alters apl changing coexpressed confirms develops engineered fuses heterodimerize hl60 leucine lost nb4 pml proline promyelocytic r4 rar rares relapsed relieved repressed retain retains retinoid subclone subclones unrearranged
Tagcloud (Intersection) ?		cd18