GGA2 and ARF1

Number of citations of the paper that reports this interaction (PubMedID 10747089)
57

Data Source:
HPRD (two hybrid, in vitro)

		GGA2	ARF1
Description		golgi associated, gamma adaptin ear containing, ARF binding protein 2	ARF GTPase 1
Image
GO Annotations	Cellular Component	Endosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Membrane Clathrin-coated Vesicle Early Endosome Membrane	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endomembrane System Postsynaptic Density Membrane Sarcomere Cell Leading Edge Protein-containing Complex Neuron Projection Synapse Extracellular Exosome
	Molecular Function	Protein Binding Small GTPase Binding Phosphatidylinositol Binding Ubiquitin Binding	Nucleotide Binding Magnesium Ion Binding RNA Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein Domain Specific Binding
	Biological Process	Intracellular Protein Transport Golgi To Plasma Membrane Transport Protein Transport Vesicle-mediated Transport Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport	Regulation Of Receptor Internalization Intracellular Copper Ion Homeostasis Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Regulation Of Arp2/3 Complex-mediated Actin Nucleation Long-term Synaptic Depression Dendritic Spine Organization Cellular Response To Virus Mitotic Cleavage Furrow Ingression
Pathways		TBC/RABGAPs Amyloid fiber formation	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Nef Mediated CD4 Down-regulation trans-Golgi Network Vesicle Budding MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Glycosphingolipid transport
Drugs			1,3-Propanediol Guanosine-3'-monophosphate-5'-diphosphate Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate Brefeldin A Myristic acid Chlortetracycline Glycerin
Diseases
GWAS			Adolescent idiopathic scoliosis ( 31417091)
Interacting Genes		43 interacting genes: ADRA2B AFTPH AP1G1 APP ARF1 ARF3 ATXN1 BACE1 BACE2 CA8 CCDC91 CLINT1 CLTC ETS1 FBXO7 GGA1 GGA3 GOLGA2 GTPBP4 HGS HTT IGF2R JUN LRP3 M6PR MAP3K1 MEMO1 NPM1 PIN1 RABEP1 RABGEF1 RNF11 RTN4IP1 SORL1 SORT1 SPG21 STAB1 SYNRG TOLLIP TP53 TRIM23 VPS18 ZNF536	50 interacting genes: AGAP1 AGAP2 AP1B1 AP1G1 AP3B1 AP3D1 AP3S2 AP4E1 AP4M1 ARFGAP1 ARFIP1 ARFIP2 ARHGAP21 ASAP1 ASAP2 CHRM3 COPB1 COPE COPG1 CYTH1 CYTH2 DENND1A DENND1B DUX4 EEF1G ERBB2 GGA1 GGA2 GGA3 GORAB GOSR2 HTR2A INSR KDELR1 MDM4 NOA1 NPM1 PICK1 PIP5K1A PLD1 PLD2 PLEKHA8 PLIN2 RALA SCYL1 SNCA TMED10 TMED2 TMEM106A WBP11
Entrez ID		23062	375
HPRD ID		09347	00054
Ensembl ID		ENSG00000103365	ENSG00000143761
Uniprot IDs		Q9UJY4	P84077
PDB IDs		1MHQ	1HUR 1RE0 1U81 3O47 4HMY 6CM9 6CRI 6D83 6D84 6DFF 6FAE 7DN8 7DN9 7MGE 7R4H 7UX3 8D4C 8D4D 8D4E 8D4F 8D4G 8D9R 8D9S 8D9U 8D9W 8SDW 9C58 9C59 9C5A 9C5B
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Intracellular Transport Early Endosome Endosome Cellular Localization Establishment Of Protein Localization Establishment Of Localization In Cell Protein Transport Intracellular Protein Transport Endocytosis Golgi Apparatus Lysosomal Transport Trans-Golgi Network Import Into Cell Intracellular Protein Localization Vacuolar Transport Clathrin-coated Vesicle Golgi Vesicle Transport Recycling Endosome Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Protein Targeting To Lysosome Protein Targeting Perinuclear Region Of Cytoplasm Establishment Of Protein Localization To Organelle Protein Targeting To Vacuole Protein-containing Complex Trans-Golgi Network Membrane Protein Localization To Lysosome Endosome Membrane Establishment Of Protein Localization To Vacuole Early Endosome Membrane Cytoplasmic Vesicle Cytosolic Transport Clathrin-coated Pit Retromer Complex Binding Golgi To Lysosome Transport Nuclear Envelope Lumen Lysosome Protein Localization To Organelle AP-1 Adaptor Complex Endosomal Transport Protein Localization To Vacuole Ubiquitin Binding Protein Transporter Activity Regulation Of Amyloid Precursor Protein Catabolic Process Trans-Golgi Network Transport Vesicle Golgi To Vacuole Transport Vesicle-mediated Transport To The Plasma Membrane Amyloid-beta Metabolic Process	Vesicle-mediated Transport Intracellular Protein Localization Golgi Apparatus Protein Transport Establishment Of Protein Localization Cellular Localization Intracellular Transport Establishment Of Localization In Cell Golgi Vesicle Transport Intracellular Protein Transport Membrane Coat Golgi Membrane Cytoplasmic Vesicle Membrane COPI-coated Vesicle Membrane Trans-Golgi Network Membrane Melanosome Assembly Localization Within Membrane Platelet Dense Granule Organization Post-Golgi Vesicle-mediated Transport Vesicle Cargo Loading COPI Vesicle Coat COPI-coated Vesicle Melanosome Organization Pigment Granule Organization Endoplasmic Reticulum-Golgi Intermediate Compartment Protein Localization To Membrane Golgi To Vacuole Transport Early Endosome Transport Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Trans-Golgi Network Secretory Granule Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Localization To Cell Surface Intra-Golgi Vesicle-mediated Transport Organelle Organization Vesicle Organization Clathrin-coated Vesicle Membrane Synaptic Vesicle Transport Vesicle Coating AP-3 Adaptor Complex Protein Localization To Cell Periphery Endocytosis Clathrin Adaptor Complex Organelle Transport Along Microtubule Cytosol Synaptic Vesicle Budding From Endosome Vacuolar Transport
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