GGA2 and BACE2

Number of citations of the paper that reports this interaction (PubMedID 12135764)
0

Data Source:
BioGRID (unspecified method, pull down)

		GGA2	BACE2
Description		golgi associated, gamma adaptin ear containing, ARF binding protein 2	beta-secretase 2
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GO Annotations	Cellular Component	Endosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Membrane Clathrin-coated Vesicle Early Endosome Membrane	Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Melanosome Membrane Melanosome
	Molecular Function	Protein Binding Small GTPase Binding Phosphatidylinositol Binding Ubiquitin Binding	Aspartic-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Intracellular Protein Transport Golgi To Plasma Membrane Transport Protein Transport Vesicle-mediated Transport Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport	Proteolysis Membrane Protein Ectodomain Proteolysis Protein Processing Peptide Hormone Processing Melanosome Organization Glucose Homeostasis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Amyloid-beta Metabolic Process
Pathways		TBC/RABGAPs Amyloid fiber formation
Drugs
Diseases
GWAS			Adult body size ( 32376654) Body mass index ( 25673413) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Elevated fasting plasma glucose ( 30004843) Glycemic traits (pregnancy) ( 23903356) Systemic lupus erythematosus ( 32771030)
Interacting Genes		43 interacting genes: ADRA2B AFTPH AP1G1 APP ARF1 ARF3 ATXN1 BACE1 BACE2 CA8 CCDC91 CLINT1 CLTC ETS1 FBXO7 GGA1 GGA3 GOLGA2 GTPBP4 HGS HTT IGF2R JUN LRP3 M6PR MAP3K1 MEMO1 NPM1 PIN1 RABEP1 RABGEF1 RNF11 RTN4IP1 SORL1 SORT1 SPG21 STAB1 SYNRG TOLLIP TP53 TRIM23 VPS18 ZNF536	5 interacting genes: APP GGA1 GGA2 PCM1 SNRNP70
Entrez ID		23062	25825
HPRD ID		09347	05744
Ensembl ID		ENSG00000103365	ENSG00000182240
Uniprot IDs		Q9UJY4	Q9Y5Z0
PDB IDs		1MHQ	2EWY 3ZKG 3ZKI 3ZKM 3ZKN 3ZKQ 3ZKS 3ZKX 3ZL7 3ZLQ 4BEL 4BFB 6JSZ 6UJ0 6UJ1 7D5B 7D5U 7F1G 7N4N
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Intracellular Transport Early Endosome Endosome Cellular Localization Establishment Of Protein Localization Establishment Of Localization In Cell Protein Transport Intracellular Protein Transport Endocytosis Golgi Apparatus Lysosomal Transport Trans-Golgi Network Import Into Cell Intracellular Protein Localization Vacuolar Transport Clathrin-coated Vesicle Golgi Vesicle Transport Recycling Endosome Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Protein Targeting To Lysosome Protein Targeting Perinuclear Region Of Cytoplasm Establishment Of Protein Localization To Organelle Protein Targeting To Vacuole Protein-containing Complex Trans-Golgi Network Membrane Protein Localization To Lysosome Endosome Membrane Establishment Of Protein Localization To Vacuole Early Endosome Membrane Cytoplasmic Vesicle Cytosolic Transport Clathrin-coated Pit Retromer Complex Binding Golgi To Lysosome Transport Nuclear Envelope Lumen Lysosome Protein Localization To Organelle AP-1 Adaptor Complex Endosomal Transport Protein Localization To Vacuole Ubiquitin Binding Protein Transporter Activity Regulation Of Amyloid Precursor Protein Catabolic Process Trans-Golgi Network Transport Vesicle Golgi To Vacuole Transport Vesicle-mediated Transport To The Plasma Membrane Amyloid-beta Metabolic Process	Regulation Of Protein Folding
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