GGA2 and LRP3

Number of citations of the paper that reports this interaction (PubMedID 11390366)
0

Data Source:
HPRD (two hybrid, in vitro)

		GGA2	LRP3
Description		golgi associated, gamma adaptin ear containing, ARF binding protein 2	LDL receptor related protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Membrane Clathrin-coated Vesicle Early Endosome Membrane	Plasma Membrane Clathrin-coated Pit Membrane
	Molecular Function	Protein Binding Small GTPase Binding Phosphatidylinositol Binding Ubiquitin Binding
	Biological Process	Intracellular Protein Transport Golgi To Plasma Membrane Transport Protein Transport Vesicle-mediated Transport Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport	Endocytosis Receptor-mediated Endocytosis Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Vesicle-mediated Transport Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Transport Across Blood-brain Barrier
Pathways		TBC/RABGAPs Amyloid fiber formation
Drugs
Diseases
GWAS			Asthma ( 31959851) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433)
Interacting Genes		43 interacting genes: ADRA2B AFTPH AP1G1 APP ARF1 ARF3 ATXN1 BACE1 BACE2 CA8 CCDC91 CLINT1 CLTC ETS1 FBXO7 GGA1 GGA3 GOLGA2 GTPBP4 HGS HTT IGF2R JUN LRP3 M6PR MAP3K1 MEMO1 NPM1 PIN1 RABEP1 RABGEF1 RNF11 RTN4IP1 SORL1 SORT1 SPG21 STAB1 SYNRG TOLLIP TP53 TRIM23 VPS18 ZNF536	3 interacting genes: GGA1 GGA2 MTNR1A
Entrez ID		23062	4037
HPRD ID		09347	04406
Ensembl ID		ENSG00000103365	ENSG00000130881
Uniprot IDs		Q9UJY4	O75074
PDB IDs		1MHQ
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Intracellular Transport Early Endosome Endosome Cellular Localization Establishment Of Protein Localization Establishment Of Localization In Cell Protein Transport Intracellular Protein Transport Endocytosis Golgi Apparatus Lysosomal Transport Trans-Golgi Network Import Into Cell Intracellular Protein Localization Vacuolar Transport Clathrin-coated Vesicle Golgi Vesicle Transport Recycling Endosome Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Protein Targeting To Lysosome Protein Targeting Perinuclear Region Of Cytoplasm Establishment Of Protein Localization To Organelle Protein Targeting To Vacuole Protein-containing Complex Trans-Golgi Network Membrane Protein Localization To Lysosome Endosome Membrane Establishment Of Protein Localization To Vacuole Early Endosome Membrane Cytoplasmic Vesicle Cytosolic Transport Clathrin-coated Pit Retromer Complex Binding Golgi To Lysosome Transport Nuclear Envelope Lumen Lysosome Protein Localization To Organelle AP-1 Adaptor Complex Endosomal Transport Protein Localization To Vacuole Ubiquitin Binding Protein Transporter Activity Regulation Of Amyloid Precursor Protein Catabolic Process Trans-Golgi Network Transport Vesicle Golgi To Vacuole Transport Vesicle-mediated Transport To The Plasma Membrane Amyloid-beta Metabolic Process	Golgi To Plasma Membrane Protein Transport Protein Localization To Cell Surface Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Ubiquitin Binding Phosphatidylinositol Binding Post-Golgi Vesicle-mediated Transport Vesicle-mediated Transport To The Plasma Membrane Protein Localization To Plasma Membrane Early Endosome Membrane Establishment Of Protein Localization To Membrane Trans-Golgi Network Protein Localization To Cell Periphery Melatonin Receptor Activity Endosome Membrane Small GTPase Binding Golgi Vesicle Transport Protein Localization To Membrane Protein Localization To Ciliary Membrane Hormone Binding Localization Within Membrane Intracellular Protein Transport Mating Behavior Reproductive Behavior Endosome G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Protein Localization To Cilium Protein Transport Clathrin-coated Vesicle Vesicle-mediated Transport Intracellular Transport Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Establishment Of Protein Localization Golgi Apparatus Retrograde Transport, Endosome To Golgi
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