DNAJB2 and FBXO25

Number of citations of the paper that reports this interaction (PubMedID 23940030)
41

Data Source:
BioGRID (enzymatic study)

		DNAJB2	FBXO25
Description		DnaJ heat shock protein family (Hsp40) member B2	F-box protein 25
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Inclusion Body Nuclear Membrane Perinuclear Region Of Cytoplasm Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex
	Molecular Function	ATPase Activator Activity Protein Binding Hsp70 Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Unfolded Protein Binding Protein-folding Chaperone Binding Proteasome Binding Protein Serine/threonine Kinase Binding Ubiquitin-modified Protein Reader Activity Protein Transporter Activity	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Protein Folding Response To Unfolded Protein Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Growth Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ATP-dependent Activity Regulation Of Protein Localization ERAD Pathway Protein Refolding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neuron Cellular Homeostasis Negative Regulation Of Inclusion Body Assembly Negative Regulation Of Protein Deubiquitination Regulation Of Protein Folding	Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS			Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)
Interacting Genes		11 interacting genes: CSNK2A1 FBXO25 HSPA4 MAP3K1 NEDD8 RPS27A SMAD4 UBA52 UBC UBQLN1 VPS26C	82 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		3300	26260
HPRD ID		07249	16439
Ensembl ID		ENSG00000135924	ENSG00000147364
Uniprot IDs		P25686	Q8TCJ0
PDB IDs		2LGW
Enriched GO Terms of Interacting Partners?		Protein Tag Activity Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Endocytic Vesicle Membrane Protein Ubiquitination Aggrephagy Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Protein Metabolic Process Post-translational Protein Modification Vesicle Protein Modification Process Mitochondrial Outer Membrane Nucleus Macromolecule Metabolic Process Catabolic Process Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Proteolysis Negative Regulation Of Store-operated Calcium Channel Activity Endosome Membrane Cytosol Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Protein Kinase CK2 Complex Regulation Of Protein Catabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Proteolysis Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis Cytosolic Ribosome Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Protein Catabolic Process Cytoplasmic Translation Positive Regulation Of Aggrephagy Sulfate Binding Endocardial Cell Differentiation Cellular Response To Camptothecin Macroautophagy SMAD Protein Complex Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Atrioventricular Valve Formation Formation Of Anatomical Boundary Mesendoderm Development Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis	Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?