DNAJB2 and VPS26C

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DNAJB2	VPS26C
Description		DnaJ heat shock protein family (Hsp40) member B2	VPS26 endosomal protein sorting factor C
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Inclusion Body Nuclear Membrane Perinuclear Region Of Cytoplasm Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Nucleus Endosome
	Molecular Function	ATPase Activator Activity Protein Binding Hsp70 Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Unfolded Protein Binding Protein-folding Chaperone Binding Proteasome Binding Protein Serine/threonine Kinase Binding Ubiquitin-modified Protein Reader Activity Protein Transporter Activity	Protein Binding
	Biological Process	Protein Folding Response To Unfolded Protein Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Growth Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ATP-dependent Activity Regulation Of Protein Localization ERAD Pathway Protein Refolding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neuron Cellular Homeostasis Negative Regulation Of Inclusion Body Assembly Negative Regulation Of Protein Deubiquitination Regulation Of Protein Folding	Intracellular Protein Transport Endocytic Recycling
Pathways
Drugs
Diseases
GWAS
Interacting Genes		11 interacting genes: CSNK2A1 FBXO25 HSPA4 MAP3K1 NEDD8 RPS27A SMAD4 UBA52 UBC UBQLN1 VPS26C	44 interacting genes: AGTPBP1 ARHGAP21 ASH1L CBLB CCDC85A CIPC DCLK1 DDIT4L DECR2 DNAJB2 EPHB6 INCA1 KIF1A KIF21A LRIF1 MAML3 MAPK6 MAPK8IP1 MDM4 MEI4 MEOX2 MRPS35 MYRIP NRCAM NSMF PALS2 PCM1 PEG10 PMS2 PRKD2 PTPN21 RAB39B RAP1GAP RAP1GAP2 SETMAR TAF1C TEPSIN TET2 TRAPPC1 U2AF1 VPS26A VPS35L XPA ZNF655
Entrez ID		3300	10311
HPRD ID		07249	10390
Ensembl ID		ENSG00000135924	ENSG00000157538
Uniprot IDs		P25686	A8MTY9 A8MY26 O14972
PDB IDs		2LGW	8P0X 8SYN 8SYO 9AU7
Enriched GO Terms of Interacting Partners?		Protein Tag Activity Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Endocytic Vesicle Membrane Protein Ubiquitination Aggrephagy Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Protein Metabolic Process Post-translational Protein Modification Vesicle Protein Modification Process Mitochondrial Outer Membrane Nucleus Macromolecule Metabolic Process Catabolic Process Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Proteolysis Negative Regulation Of Store-operated Calcium Channel Activity Endosome Membrane Cytosol Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Protein Kinase CK2 Complex Regulation Of Protein Catabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Proteolysis Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis Cytosolic Ribosome Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Protein Catabolic Process Cytoplasmic Translation Positive Regulation Of Aggrephagy Sulfate Binding Endocardial Cell Differentiation Cellular Response To Camptothecin Macroautophagy SMAD Protein Complex Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Atrioventricular Valve Formation Formation Of Anatomical Boundary Mesendoderm Development Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
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