DNAJB2 and HSPA4

Number of citations of the paper that reports this interaction (PubMedID 28504929)
81

Data Source:
BioGRID (imaging technique, pull down, affinity chromatography technology)

		DNAJB2	HSPA4
Description		DnaJ heat shock protein family (Hsp40) member B2	heat shock protein family A (Hsp70) member 4
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Inclusion Body Nuclear Membrane Perinuclear Region Of Cytoplasm Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Nucleus Cytoplasm Cytosol Organelle Extracellular Exosome
	Molecular Function	ATPase Activator Activity Protein Binding Hsp70 Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Unfolded Protein Binding Protein-folding Chaperone Binding Proteasome Binding Protein Serine/threonine Kinase Binding Ubiquitin-modified Protein Reader Activity Protein Transporter Activity	Nucleotide Binding Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Protein Folding Response To Unfolded Protein Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Growth Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ATP-dependent Activity Regulation Of Protein Localization ERAD Pathway Protein Refolding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neuron Cellular Homeostasis Negative Regulation Of Inclusion Body Assembly Negative Regulation Of Protein Deubiquitination Regulation Of Protein Folding	Protein Folding Response To Unfolded Protein Protein Import Into Mitochondrial Matrix Chaperone-mediated Protein Complex Assembly
Pathways			Regulation of HSF1-mediated heat shock response
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS			A body shape index ( 34021172) Breast cancer ( 29059683) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) High density lipoprotein cholesterol levels ( 31928498) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Triglyceride levels ( 31928498 32203549 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		11 interacting genes: CSNK2A1 FBXO25 HSPA4 MAP3K1 NEDD8 RPS27A SMAD4 UBA52 UBC UBQLN1 VPS26C	72 interacting genes: ABCC2 AGTRAP APPBP2 BAG1 BAG2 BRMS1 CALM1 CD40 CDC73 CDKN2A CEBPA CSNK1A1 CSNK2A1 DDIT4 DNAJB2 DUSP1 EGFR ESR1 FANCC FES FKBP4 GATA1 GRPEL2 GSK3B GZMA HAP1 HDAC3 HNRNPD HSF2 HSPB1 HSPBP1 IKBKG KPNA2 KRT18 MUC1 NAA10 NEDD8 NFKB1 NR3C2 OLR1 PA2G4 PHLDA1 POU6F2 PPP1CA PRKACA PRKCB PRKCD PRKCG PRSS23 PSMD10 PTEN RAF1 RAP1A REL RELA SENP8 SGTA SIRPA SMAD3 ST13 STIP1 STK4 STUB1 SUGT1 TERT TOMM40 TRAF6 TRIM32 TTC1 UBE2L3 UBE2M UBE3A
Entrez ID		3300	3308
HPRD ID		07249	09025
Ensembl ID		ENSG00000135924	ENSG00000170606
Uniprot IDs		P25686	P34932
PDB IDs		2LGW
Enriched GO Terms of Interacting Partners?		Protein Tag Activity Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Endocytic Vesicle Membrane Protein Ubiquitination Aggrephagy Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Protein Metabolic Process Post-translational Protein Modification Vesicle Protein Modification Process Mitochondrial Outer Membrane Nucleus Macromolecule Metabolic Process Catabolic Process Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Proteolysis Negative Regulation Of Store-operated Calcium Channel Activity Endosome Membrane Cytosol Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Protein Kinase CK2 Complex Regulation Of Protein Catabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Proteolysis Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis Cytosolic Ribosome Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Protein Catabolic Process Cytoplasmic Translation Positive Regulation Of Aggrephagy Sulfate Binding Endocardial Cell Differentiation Cellular Response To Camptothecin Macroautophagy SMAD Protein Complex Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Atrioventricular Valve Formation Formation Of Anatomical Boundary Mesendoderm Development Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis	Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Cytosol Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of Primary Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Protein Catabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Post-translational Protein Modification Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Response To Lipid Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Post-translational Protein Modification Intracellular Signaling Cassette Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cellular Response To Oxygen-containing Compound Regulation Of Protein Stability Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Lipid Negative Regulation Of Metabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Apoptotic Signaling Pathway
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