DNAJB2

Description		DnaJ heat shock protein family (Hsp40) member B2
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Inclusion Body Nuclear Membrane Perinuclear Region Of Cytoplasm Cytoplasmic Side Of Endoplasmic Reticulum Membrane
	Molecular Function	ATPase Activator Activity Protein Binding Hsp70 Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Unfolded Protein Binding Protein-folding Chaperone Binding Proteasome Binding Protein Serine/threonine Kinase Binding Ubiquitin-modified Protein Reader Activity Protein Transporter Activity
	Biological Process	Protein Folding Response To Unfolded Protein Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Growth Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ATP-dependent Activity Regulation Of Protein Localization ERAD Pathway Protein Refolding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neuron Cellular Homeostasis Negative Regulation Of Inclusion Body Assembly Negative Regulation Of Protein Deubiquitination Regulation Of Protein Folding
Pathways
Drugs
Diseases
GWAS
Interacting Genes		11 interacting genes: CSNK2A1 FBXO25 HSPA4 MAP3K1 NEDD8 RPS27A SMAD4 UBA52 UBC UBQLN1 VPS26C
Entrez ID		3300
HPRD ID		07249
Ensembl ID		ENSG00000135924
Uniprot IDs		P25686
PDB IDs		2LGW
Enriched GO Terms of Interacting Partners?		Protein Tag Activity Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Endocytic Vesicle Membrane Protein Ubiquitination Aggrephagy Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Protein Metabolic Process Post-translational Protein Modification Vesicle Protein Modification Process Mitochondrial Outer Membrane Nucleus Macromolecule Metabolic Process Catabolic Process Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Proteolysis Negative Regulation Of Store-operated Calcium Channel Activity Endosome Membrane Cytosol Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Protein Kinase CK2 Complex Regulation Of Protein Catabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Proteolysis Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis Cytosolic Ribosome Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Protein Catabolic Process Cytoplasmic Translation Positive Regulation Of Aggrephagy Sulfate Binding Endocardial Cell Differentiation Cellular Response To Camptothecin Macroautophagy SMAD Protein Complex Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Atrioventricular Valve Formation Formation Of Anatomical Boundary Mesendoderm Development Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
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