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HTRA2 and ACTA1
Number of citations of the paper that reports this interaction (PubMedID
17266347
)
0
Data Source:
BioGRID
(enzymatic study)
HTRA2
ACTA1
Description
HtrA serine peptidase 2
actin alpha 1, skeletal muscle
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Mitochondrion
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Cytoskeleton
Cytoplasmic Side Of Plasma Membrane
Membrane
Mitochondrial Membrane
Protein-containing Complex
CD40 Receptor Complex
Serine-type Endopeptidase Complex
Stress Fiber
Extracellular Space
Cytoplasm
Cytosol
Cytoskeleton
Striated Muscle Thin Filament
Actin Filament
Actin Cytoskeleton
Sarcomere
Lamellipodium
Filopodium
Cell Body
Extracellular Exosome
Blood Microparticle
Molecular Function
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Hydrolase Activity
Protein Serine/threonine Kinase Inhibitor Activity
Identical Protein Binding
Unfolded Protein Binding
Ubiquitin Ligase Inhibitor Activity
Nucleotide Binding
Structural Constituent Of Cytoskeleton
Protein Binding
ATP Binding
Hydrolase Activity
Myosin Binding
ADP Binding
Biological Process
Proteolysis
Ceramide Metabolic Process
Apoptotic Process
Mitochondrion Organization
Adult Walking Behavior
Adult Locomotory Behavior
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Herbicide
Programmed Cell Death
Protein Autoprocessing
Pentacyclic Triterpenoid Metabolic Process
Protein Catabolic Process
Forebrain Development
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To Interferon-beta
Intracellular Signal Transduction
Mitochondrial Protein Catabolic Process
Regulation Of Multicellular Organism Growth
Positive Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Cell Cycle
Neuron Development
Neuron Apoptotic Process
Cellular Response To Retinoic Acid
Cellular Response To Growth Factor Stimulus
Intrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Positive Regulation Of Execution Phase Of Apoptosis
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Type 2 Mitophagy
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Muscle Contraction
Positive Regulation Of Gene Expression
Skeletal Muscle Thin Filament Assembly
Skeletal Muscle Fiber Development
Mesenchyme Migration
Pathways
Mitochondrial protein degradation
Mitochondrial unfolded protein response (UPRmt)
Striated Muscle Contraction
Regulation of CDH1 Function
Formation of the dystrophin-glycoprotein complex (DGC)
Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Latrunculin A
Sucrose
Ulapualide A
Kabiramide C
Jaspisamide A
Tmr
1-Methylhistidine
Phosphoaminophosphonic Acid-Adenylate Ester
Aplyronine A
Reidispongiolide A
Reidispongiolide C
Sphinxolide B
Latrunculin B
Diseases
Parkinson's disease (PD)
Cap myopathy
Congenital fiber type disproportion (CFTD)
Nemaline myopathy
GWAS
Interacting Genes
41 interacting genes:
ACTA1
ALDH1A2
APC
APP
AREL1
BIRC2
BIRC3
BIRC6
BIRC7
CAD
CCAR2
CDK1
CDK5
CSN1S1
CSN2
DIABLO
EEF1A1
EIF4G1
HSD17B10
IMMT
ITGA7
MAPK11
MAPK12
MAPK13
MAPK14
MAPK3
MUL1
PAG1
PDXDC1
PDXDC2P-NPIPB14P
PEA15
TRIM28
TUBA1A
TUBB
TUBB6
TUBB7P
UBC
USP7
VIM
VPS4B
XIAP
115 interacting genes:
ABL1
ABRA
ACTR10
ACTR1B
ADSS2
AFAP1
AIF1
AJUBA
AMOT
ANXA2
BIN1
CCIN
CCT2
CCT4
CCT5
CFL1
CLIC5
CNN1
CORO2B
COTL1
CTNND1
CTTN
CYFIP1
CYTH1
DHX9
DLG1
DMD
DNASE1
DNMBP
DTNA
DUX4L9
EGFR
EPB41
EPB41L2
EPS8
FGD4
FHOD1
FSCN1
GAS2
GAS7
GC
GSN
HCLS1
HDAC4
HIP1R
HSPB2
HTRA2
IQGAP1
ITGA2
ITPKA
KIF23
KLHL20
LASP1
LINC00624
MACF1
MAP1A
MAPT
MIB2
MINPP1
MYL1
MYLK
MYO10
MYO6
MYO7A
MYO9B
NEXN
NR3C2
NRAP
PAK1
PARVA
PCYT1B
PFDN1
PFN1
PHACTR1
PLD1
PPP1R9B
PRKCA
PRKCD
PRKCE
RAC1
RNF167
RPS6KB1
S100A1
S100A4
SCIN
SMTN
SNCA
SORBS1
SPRR1A
SPTA1
SPTAN1
SPTBN2
TAGLN
TJP1
TLN1
TMSB4X
TMSB4Y
TNNI1
TNNI3
TNNI3K
TP53
TPM2
TPM3
TRIM55
TRIM63
TTN
UBC
USP25
USP6NL
UTRN
VASP
VAV1
VCL
VIL1
XIRP1
Entrez ID
27429
58
HPRD ID
05919
00030
Ensembl ID
ENSG00000115317
ENSG00000143632
Uniprot IDs
A0A384MDW9
A0A8Q3SIX7
O43464
P68133
PDB IDs
1LCY
2PZD
5FHT
5M3N
5M3O
5TNY
5TNZ
5TO0
5TO1
5WYN
7VGE
8AUK
8E2K
7RNS
7RNU
7RNV
9DUU
9DUV
Enriched GO Terms of Interacting Partners
?
Cell Death
Apoptotic Process
Programmed Cell Death
MAP Kinase Activity
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
MAPK Cascade
Regulation Of Cell Cycle
Ubiquitin-protein Transferase Activity
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Transferase Activity
Cysteine-type Endopeptidase Inhibitor Activity
Cytosol
Intracellular Signal Transduction
Ubiquitin Protein Ligase Activity
Protein Kinase Activity
Regulation Of Apoptotic Process
Intracellular Signaling Cassette
Structural Constituent Of Cytoskeleton
Regulation Of Programmed Cell Death
Response To Cytokine
Response To Peptide
Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Regulation Of Inflammatory Response
Acetylcholine Receptor Activator Activity
Cytoplasm
Response To Light Stimulus
Positive Regulation Of Post-translational Protein Modification
Glial Cell Development
Protein Serine Kinase Activity
Post-translational Protein Modification
Regulation Of Post-translational Protein Modification
Nucleotide Binding
P38MAPK Cascade
Protein Modification By Small Protein Conjugation
Regulation Of Protein Metabolic Process
Regulation Of Intracellular Transport
Protein Serine/threonine Kinase Activity
Protein Metabolic Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Growth
Regulation Of Synapse Organization
Response To Radiation
DNA Damage Response
Protein Ubiquitination
Regulation Of Protein Ubiquitination
Regulation Of Developmental Growth
Regulation Of Toll-like Receptor Signaling Pathway
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Protein Modification Process
Actin Binding
Actin Filament Binding
Cytoskeleton
Actin Cytoskeleton
Actin Filament-based Process
Cytoplasm
Actin Filament Organization
Regulation Of Supramolecular Fiber Organization
Regulation Of Actin Filament Organization
Actin Cytoskeleton Organization
Supramolecular Fiber Organization
Regulation Of Actin Polymerization Or Depolymerization
Regulation Of Actin Cytoskeleton Organization
Regulation Of Actin Filament Polymerization
Regulation Of Actin Filament Length
Regulation Of Cytoskeleton Organization
Regulation Of Actin Filament-based Process
Cytosol
Regulation Of Cellular Component Size
Regulation Of Protein-containing Complex Assembly
Cell Cortex
Cytoskeleton Organization
Regulation Of Organelle Organization
Regulation Of Cellular Component Organization
Focal Adhesion
Positive Regulation Of Supramolecular Fiber Organization
Positive Regulation Of Organelle Organization
Positive Regulation Of Cytoskeleton Organization
Negative Regulation Of Supramolecular Fiber Organization
Lamellipodium
Ruffle
Actin Filament
Negative Regulation Of Cytoskeleton Organization
Negative Regulation Of Actin Filament Polymerization
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Protein Localization
Cortical Actin Cytoskeleton
Positive Regulation Of Cellular Component Biogenesis
Actin Polymerization Or Depolymerization
Regulation Of Biological Quality
Anchoring Junction
Organelle Organization
Ruffle Membrane
Positive Regulation Of Protein-containing Complex Assembly
Cell Projection
Filopodium
Regulation Of Cell Shape
Muscle System Process
Negative Regulation Of Actin Filament Depolymerization
Regulation Of Protein Localization
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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