ACTA1 and MYO7A

Number of citations of the paper that reports this interaction (PMID 12466270)
18

Data Source:
HPRD (in vitro)

		ACTA1	MYO7A
Gene Name		actin, alpha 1, skeletal muscle	myosin VIIA
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Extracellular Vesicular Exosome Blood Microparticle	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Lysosomal Membrane Cytosol Cell Cortex Apical Plasma Membrane Myosin VII Complex Photoreceptor Connecting Cilium Stereocilium Melanosome Synapse
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding	Microfilament Motor Activity Protein Binding Calmodulin Binding ATP Binding Protein Domain Specific Binding Spectrin Binding Actin-dependent ATPase Activity Protein Homodimerization Activity ADP Binding Actin Filament Binding
	Biological Process	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Cell Growth Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development	Phagolysosome Assembly Intracellular Protein Transport Lysosome Organization Visual Perception Sensory Perception Of Sound Actin Filament-based Movement Eye Photoreceptor Cell Development Post-embryonic Organ Morphogenesis Sensory Perception Of Light Stimulus Equilibrioception Pigment Granule Transport Auditory Receptor Cell Stereocilium Organization
Pathways		Striated Muscle Contraction	Visual phototransduction The canonical retinoid cycle in rods (twilight vision) Diseases associated with visual transduction
Drugs
Diseases
GWAS
Protein-Protein Interactions		107 interactors: ABL1 ABRA ACTR10 ACTR1B ADSS AFAP1 AIF1 AJUBA AMOT CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	11 interactors: ACTA1 CALM1 CDH23 DFNB31 KEAP1 KHDRBS1 MAP2 MYRIP PRKAR1A USH1C VEZT
Entrez ID		58	4647
HPRD ID		00030	02043
Ensembl ID		ENSG00000143632	ENSG00000137474
Uniprot IDs		P68133 Q5T8M7	B9A012 Q13402
PDB IDs		1T44
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Actin Filament-based Movement Muscle Contraction Muscle System Process Cell Projection Organization Organelle Organization Negative Regulation Of Protein Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Cellular Component Assembly Developmental Process Anatomical Structure Morphogenesis Anatomical Structure Development Negative Regulation Of Protein Complex Assembly System Development Actin-mediated Cell Contraction Response To Wounding Locomotion Cell Development Response To External Stimulus Cell Differentiation Wound Healing Multicellular Organismal Development Cell Morphogenesis Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Tissue Development Cell Projection Morphogenesis Chemotaxis Positive Regulation Of Organelle Organization Cell Part Morphogenesis Neuron Development Actin Polymerization Or Depolymerization Blood Coagulation Hemostasis Cell Junction Assembly	Retina Homeostasis Equilibrioception Sensory Perception Of Sound Sensory Perception Of Light Stimulus Sensory Perception Of Mechanical Stimulus Tissue Homeostasis Photoreceptor Cell Maintenance Multicellular Organismal Homeostasis Multicellular Organismal Development Activation Of Phospholipase C Activity Anatomical Structure Development Positive Regulation Of Phospholipase C Activity Inner Ear Receptor Cell Differentiation Mechanoreceptor Differentiation Myofibril Assembly Positive Regulation Of Phospholipase Activity Neuromuscular Process Controlling Balance Developmental Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Cellular Localization Positive Regulation Of RNA Export From Nucleus Skeletal Muscle Fiber Adaptation Parallel Actin Filament Bundle Assembly Actomyosin Structure Organization Positive Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization Embryo Development G2/M Transition Of Mitotic Cell Cycle Neuromuscular Process Positive Regulation Of Protein Metabolic Process Energy Reserve Metabolic Process Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Proteasomal Ubiquitin-independent Protein Catabolic Process Striated Muscle Cell Development Regulation Of High Voltage-gated Calcium Channel Activity Actin Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Muscle Cell Development Fibroblast Growth Factor Receptor Signaling Pathway Homeostatic Process Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Actin Filament-based Process Skeletal Muscle Thin Filament Assembly Inner Ear Development Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Organic Substance Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Tagcloud ?		annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40	11q13 15q21 1e aas admixture african americans ancestry caucasian causation chr15q21 cytoskeleton dermal descent exome genotyping gwas japanese keloid keloids mapping migratory myo1e myosin nedd4 peaks predisposition rs35641839 sporadically
Tagcloud (Difference) ?		annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40	11q13 15q21 1e aas admixture african americans ancestry caucasian causation chr15q21 cytoskeleton dermal descent exome genotyping gwas japanese keloid keloids mapping migratory myo1e myosin nedd4 peaks predisposition rs35641839 sporadically
Tagcloud (Intersection) ?