ACTA1 and SMTN

Data Source:
HPRD (in vivo, in vitro)

		ACTA1	SMTN
Gene Name		actin, alpha 1, skeletal muscle	smoothelin
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Extracellular Vesicular Exosome Blood Microparticle	Nucleoplasm Cytoplasm Cytoskeleton Actin Cytoskeleton
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding	Actin Binding Structural Constituent Of Muscle
	Biological Process	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Cell Growth Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development	Smooth Muscle Contraction Muscle Organ Development
Pathways		Striated Muscle Contraction
Drugs
Diseases
GWAS			Bulimia nervosa ( 23568457)
Protein-Protein Interactions		107 interactors: ABL1 ABRA ACTR10 ACTR1B ADSS AFAP1 AIF1 AJUBA AMOT CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	2 interactors: ACTA1 BRMS1
Entrez ID		58	6525
HPRD ID		00030	03675
Ensembl ID		ENSG00000143632	ENSG00000183963
Uniprot IDs		P68133 Q5T8M7	B4DI56 B4E229 P53814
PDB IDs		1T44	2D87
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Actin Filament-based Movement Muscle Contraction Muscle System Process Cell Projection Organization Organelle Organization Negative Regulation Of Protein Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Cellular Component Assembly Developmental Process Anatomical Structure Morphogenesis Anatomical Structure Development Negative Regulation Of Protein Complex Assembly System Development Actin-mediated Cell Contraction Response To Wounding Locomotion Cell Development Response To External Stimulus Cell Differentiation Wound Healing Multicellular Organismal Development Cell Morphogenesis Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Tissue Development Cell Projection Morphogenesis Chemotaxis Positive Regulation Of Organelle Organization Cell Part Morphogenesis Neuron Development Actin Polymerization Or Depolymerization Blood Coagulation Hemostasis Cell Junction Assembly	Skeletal Muscle Fiber Adaptation Positive Regulation Of Anoikis Skeletal Muscle Thin Filament Assembly Skeletal Myofibril Assembly Skeletal Muscle Adaptation Regulation Of Anoikis Skeletal Muscle Fiber Development Positive Regulation Of Protein Deacetylation Myotube Cell Development Response To Lithium Ion Muscle Filament Sliding Actin-myosin Filament Sliding Actin-mediated Cell Contraction Muscle Fiber Development Regulation Of Protein Deacetylation Myotube Differentiation Actin Filament-based Movement Negative Regulation Of NF-kappaB Transcription Factor Activity Histone Deacetylation Protein Deacetylation Myofibril Assembly
Tagcloud ?		annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40	aaa aaas abdominal adcy7 altogether aorta arl4c blnk chip custom cxcr4 dilatation directions dusp6 fosb gatm infrarenal itga5 lyz mfge8 pathobiological pathobiology plek prune2 ptprc studying tmodi tpm2 typically
Tagcloud (Difference) ?		annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40	aaa aaas abdominal adcy7 altogether aorta arl4c blnk chip custom cxcr4 dilatation directions dusp6 fosb gatm infrarenal itga5 lyz mfge8 pathobiological pathobiology plek prune2 ptprc studying tmodi tpm2 typically
Tagcloud (Intersection) ?