ACTA1 and MYO9B

Number of citations of the paper that reports this interaction (PMID 9490638)
19

Data Source:
HPRD (in vitro)

		ACTA1	MYO9B
Gene Name		actin, alpha 1, skeletal muscle	myosin IXB
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Extracellular Vesicular Exosome Blood Microparticle	Ruffle Cytoplasm Cytosol Cell Cortex Actin Cytoskeleton Membrane Myosin Complex Lamellipodium Filamentous Actin Filopodium Tip Perinuclear Region Of Cytoplasm
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding	Microfilament Motor Activity Actin Binding Rho GTPase Activator Activity Protein Binding Calmodulin Binding ATP Binding Zinc Ion Binding ATPase Activity Actin-dependent ATPase Activity Protein Homodimerization Activity ATP-dependent Protein Binding ADP Binding Actin Filament Binding
	Biological Process	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Cell Growth Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development	Monocyte Chemotaxis Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Establishment Of Cell Polarity Actin Filament-based Movement ARF Protein Signal Transduction Positive Regulation Of Rho GTPase Activity Macrophage Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Lamellipodium Morphogenesis
Pathways		Striated Muscle Contraction	Rho GTPase cycle Signaling by Rho GTPases Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS			Height ( 20881960)
Protein-Protein Interactions		107 interactors: ABL1 ABRA ACTR10 ACTR1B ADSS AFAP1 AIF1 AJUBA AMOT CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	6 interactors: ACTA1 ARFGEF1 CALM1 LRRC41 MOB4 PKN2
Entrez ID		58	4650
HPRD ID		00030	03677
Ensembl ID		ENSG00000143632	ENSG00000099331
Uniprot IDs		P68133 Q5T8M7	B0I1T6 Q13459 Q4LE74 Q8WVD2
PDB IDs		1T44
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Actin Filament-based Movement Muscle Contraction Muscle System Process Cell Projection Organization Organelle Organization Negative Regulation Of Protein Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Cellular Component Assembly Developmental Process Anatomical Structure Morphogenesis Anatomical Structure Development Negative Regulation Of Protein Complex Assembly System Development Actin-mediated Cell Contraction Response To Wounding Locomotion Cell Development Response To External Stimulus Cell Differentiation Wound Healing Multicellular Organismal Development Cell Morphogenesis Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Tissue Development Cell Projection Morphogenesis Chemotaxis Positive Regulation Of Organelle Organization Cell Part Morphogenesis Neuron Development Actin Polymerization Or Depolymerization Blood Coagulation Hemostasis Cell Junction Assembly	Regulation Of Cytokinesis Positive Regulation Of Protein Glycosylation In Golgi Skeletal Muscle Fiber Adaptation Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Protein Glycosylation Regulation Of High Voltage-gated Calcium Channel Activity Muscle Contraction Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Skeletal Muscle Thin Filament Assembly Regulation Of Cell Division Muscle System Process Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Skeletal Myofibril Assembly Skeletal Muscle Adaptation Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Protein Glycosylation Response To Metal Ion Exocytosis Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Rho GTPase Activity Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Ras GTPase Activity Negative Regulation Of Cation Channel Activity Polysaccharide Catabolic Process Positive Regulation Of Viral Genome Replication Response To Inorganic Substance Response To Steroid Hormone Positive Regulation Of Monooxygenase Activity Skeletal Muscle Fiber Development Regulation Of Cell Cycle Process Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Secretion By Cell Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Nitric Oxide Metabolic Process
Tagcloud ?		annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40	akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Difference) ?		annotation assembled biomedical contigs cox1 discover eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40	akap6 atf7 atxn1 bmpr2 categorize deltan grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Intersection) ?		eef1a1