HTRA2 and BIRC6

Number of citations of the paper that reports this interaction (PMID 15200957)
38

Data Source:
HPRD (in vitro, in vivo)

		HTRA2	BIRC6
Gene Name		HtrA serine peptidase 2	baculoviral IAP repeat containing 6
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Membrane CD40 Receptor Complex	Spindle Pole Endosome Trans-Golgi Network Microtubule Organizing Center Membrane Midbody
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Unfolded Protein Binding	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Ligase Activity
	Biological Process	Proteolysis Ceramide Metabolic Process Mitochondrion Organization Adult Walking Behavior Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Herbicide Positive Regulation Of Cell Death Protein Autoprocessing Pentacyclic Triterpenoid Metabolic Process Forebrain Development Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Interferon-beta Regulation Of Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Catabolic Process Negative Regulation Of Cell Cycle Neuron Development Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Execution Phase Of Apoptosis Negative Regulation Of Neuron Death Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrion Degradation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Protein Phosphorylation Apoptotic Process Mitotic Nuclear Division Positive Regulation Of Cell Proliferation Negative Regulation Of Endopeptidase Activity Protein Ubiquitination Regulation Of Cytokinesis Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Cell Division Labyrinthine Layer Development Spongiotrophoblast Layer Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		37 interactors: ACTA1 ALDH1A2 APC APP AREL1 BIRC2 BIRC3 BIRC6 BIRC7 CAD CCAR2 CDK1 CDK5 CSN1S1 CSN2 DIABLO EEF1A1 EIF4G1 HSD17B10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 PAG1 PDXDC1 PDXDC2P PEA15 TRIM28 TUBA1A TUBB TUBB6 TUBB7P USP7 VIM VPS4B XIAP	19 interactors: BIRC5 CASP3 CASP7 CASP8 CASP9 CDK1 CSNK2A1 DIABLO EXOC3 EXOC4 HTRA2 MAP2K1 PLK1 RAB8A RNF41 UBC UBE2D1 USP8 VAV2
Entrez ID		27429	57448
HPRD ID		05919	05731
Ensembl ID		ENSG00000115317	ENSG00000115760
Uniprot IDs		O43464	Q9NR09
PDB IDs		1LCY 2PZD	3CEG
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Proteolysis Cellular Protein Metabolic Process Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Proteolysis Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Protein Processing Regulation Of Protein Metabolic Process Protein Metabolic Process Regulation Of Protein Processing Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Toll-like Receptor Signaling Pathway Response To Stimulus Regulation Of Cell Death Cellular Response To Stimulus MAPK Cascade Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To Stress Regulation Of Innate Immune Response Activation Of Innate Immune Response Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Peptidase Activity Cellular Response To Stress Cellular Protein Modification Process Signal Transduction By Phosphorylation Response To Organic Substance Cellular Response To DNA Damage Stimulus Positive Regulation Of Innate Immune Response Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Stress-activated MAPK Cascade Peptidyl-serine Phosphorylation Stress-activated Protein Kinase Signaling Cascade Neurotrophin Signaling Pathway	Regulation Of Proteolysis Positive Regulation Of Proteolysis Apoptotic Process Programmed Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Cell Death Apoptotic Signaling Pathway Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Regulation Of Catalytic Activity Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Protein Processing Regulation Of Peptidase Activity Positive Regulation Of Endopeptidase Activity Mitotic Cell Cycle Process Positive Regulation Of Peptidase Activity Negative Regulation Of Cell Cycle TRIF-dependent Toll-like Receptor Signaling Pathway Intracellular Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Protein Metabolic Process Toll-like Receptor 3 Signaling Pathway Mitotic Cell Cycle Proteolysis Positive Regulation Of Cellular Metabolic Process Toll-like Receptor 4 Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway Cellular Protein Catabolic Process Activation Of Cysteine-type Endopeptidase Activity Cellular Macromolecule Catabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Response To Growth Factor Positive Regulation Of Cell Death Protein Catabolic Process Zymogen Activation Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		betal concerned decreasing designed ec endometrial er estrogen heterogeneous hnrnp hnrnps ihc immunohistochemisty insight intimate investigation link nucleus performs pharmaceutical possesses prognosis real recurrence recurrent ribonucleoprotein shows towards transformer	alt carcinogenesis consequences demonstate encode facilitated facilitates hcc hepatocellular hepatoma iaps immunoblot immunochemical indicative interacted interference knockdown lentivirus mechanistic nude overexpressed partly proognostic remarkably reversed sensitized silencing sorafenib xenograft
Tagcloud (Difference) ?		betal concerned decreasing designed ec endometrial er estrogen heterogeneous hnrnp hnrnps ihc immunohistochemisty insight intimate investigation link nucleus performs pharmaceutical possesses prognosis real recurrence recurrent ribonucleoprotein shows towards transformer	alt carcinogenesis consequences demonstate encode facilitated facilitates hcc hepatocellular hepatoma iaps immunoblot immunochemical indicative interacted interference knockdown lentivirus mechanistic nude overexpressed partly proognostic remarkably reversed sensitized silencing sorafenib xenograft
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