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HTRA2 and BIRC6
Number of citations of the paper that reports this interaction (PubMedID
15200957
)
0
Data Source:
HPRD
(in vivo, in vitro)
HTRA2
BIRC6
Description
HtrA serine peptidase 2
baculoviral IAP repeat containing 6
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Mitochondrion
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Cytoskeleton
Cytoplasmic Side Of Plasma Membrane
Membrane
Mitochondrial Membrane
Protein-containing Complex
CD40 Receptor Complex
Serine-type Endopeptidase Complex
Spindle Pole
Nucleus
Cytoplasm
Endosome
Golgi Apparatus
Trans-Golgi Network
Centrosome
Microtubule Organizing Center
Cytosol
Cytoskeleton
Membrane
Midbody
Flemming Body
Molecular Function
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Hydrolase Activity
Protein Serine/threonine Kinase Inhibitor Activity
Identical Protein Binding
Unfolded Protein Binding
Ubiquitin Ligase Inhibitor Activity
Ubiquitin-protein Transferase Activity
Cysteine-type Endopeptidase Inhibitor Activity
Protein Binding
Transferase Activity
Peptidase Inhibitor Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Proteolysis
Ceramide Metabolic Process
Apoptotic Process
Mitochondrion Organization
Adult Walking Behavior
Adult Locomotory Behavior
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Herbicide
Programmed Cell Death
Protein Autoprocessing
Pentacyclic Triterpenoid Metabolic Process
Protein Catabolic Process
Forebrain Development
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To Interferon-beta
Intracellular Signal Transduction
Mitochondrial Protein Catabolic Process
Regulation Of Multicellular Organism Growth
Positive Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Cell Cycle
Neuron Development
Neuron Apoptotic Process
Cellular Response To Retinoic Acid
Cellular Response To Growth Factor Stimulus
Intrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Positive Regulation Of Execution Phase Of Apoptosis
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Type 2 Mitophagy
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Placenta Development
Protein Phosphorylation
Apoptotic Process
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Protein Ubiquitination
Regulation Of Cytokinesis
Regulation Of Cell Population Proliferation
Negative Regulation Of Apoptotic Process
Cell Division
Labyrinthine Layer Development
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Mitochondrial protein degradation
Mitochondrial unfolded protein response (UPRmt)
ALK mutants bind TKIs
Signaling by ALK fusions and activated point mutants
Drugs
Diseases
Parkinson's disease (PD)
GWAS
Chronotype (
30696823
)
Coffee consumption (
31046077
)
General risk tolerance (MTAG) (
30643258
)
Male-pattern baldness (
28196072
)
Red cell distribution width (
32888494
)
Refractive error (
32231278
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Interacting Genes
41 interacting genes:
ACTA1
ALDH1A2
APC
APP
AREL1
BIRC2
BIRC3
BIRC6
BIRC7
CAD
CCAR2
CDK1
CDK5
CSN1S1
CSN2
DIABLO
EEF1A1
EIF4G1
HSD17B10
IMMT
ITGA7
MAPK11
MAPK12
MAPK13
MAPK14
MAPK3
MUL1
PAG1
PDXDC1
PDXDC2P-NPIPB14P
PEA15
TRIM28
TUBA1A
TUBB
TUBB6
TUBB7P
UBC
USP7
VIM
VPS4B
XIAP
29 interacting genes:
ARIH1
BIRC2
BIRC5
CASP3
CASP8
CASP9
CDK1
CSNK2A1
DIABLO
EXOC3
EXOC4
GABARAP
HTRA2
MAP1LC3B
MAP2K1
NEDD4
PLK1
RAB8A
RACK1
RNF144A
RNF4
RNF41
UBA6
UBC
UBE2D1
UBE3C
USP8
VAV2
VCL
Entrez ID
27429
57448
HPRD ID
05919
05731
Ensembl ID
ENSG00000115317
ENSG00000115760
Uniprot IDs
A0A384MDW9
A0A8Q3SIX7
O43464
A0A8V8TQB4
A0A8V8TR92
Q9NR09
PDB IDs
1LCY
2PZD
5FHT
5M3N
5M3O
5TNY
5TNZ
5TO0
5TO1
5WYN
7VGE
8AUK
8E2K
3CEG
8ATM
8ATO
8ATU
8ATX
8AUK
8AUW
8E2D
8E2E
8E2F
8E2G
8E2H
8E2I
8E2K
Enriched GO Terms of Interacting Partners
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Cell Death
Apoptotic Process
Programmed Cell Death
MAP Kinase Activity
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
MAPK Cascade
Regulation Of Cell Cycle
Ubiquitin-protein Transferase Activity
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Transferase Activity
Cysteine-type Endopeptidase Inhibitor Activity
Cytosol
Intracellular Signal Transduction
Ubiquitin Protein Ligase Activity
Protein Kinase Activity
Regulation Of Apoptotic Process
Intracellular Signaling Cassette
Structural Constituent Of Cytoskeleton
Regulation Of Programmed Cell Death
Response To Cytokine
Response To Peptide
Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Regulation Of Inflammatory Response
Acetylcholine Receptor Activator Activity
Cytoplasm
Response To Light Stimulus
Positive Regulation Of Post-translational Protein Modification
Glial Cell Development
Protein Serine Kinase Activity
Post-translational Protein Modification
Regulation Of Post-translational Protein Modification
Nucleotide Binding
P38MAPK Cascade
Protein Modification By Small Protein Conjugation
Regulation Of Protein Metabolic Process
Regulation Of Intracellular Transport
Protein Serine/threonine Kinase Activity
Protein Metabolic Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Growth
Regulation Of Synapse Organization
Response To Radiation
DNA Damage Response
Protein Ubiquitination
Regulation Of Protein Ubiquitination
Regulation Of Developmental Growth
Regulation Of Toll-like Receptor Signaling Pathway
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Protein Modification Process
Post-translational Protein Modification
Protein Ubiquitination
Proteolysis
Cytosol
Protein Modification By Small Protein Conjugation
Protein Modification Process
Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Macromolecule Catabolic Process
Intracellular Signal Transduction
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-protein Transferase Activity
Apoptotic Process
Catabolic Process
Programmed Cell Death
Cell Death
Midbody
Mitotic Cytokinesis
Response To Anesthetic
Execution Phase Of Apoptosis
Ubiquitin Protein Ligase Activity
Regulation Of Autophagy
Regulation Of Apoptotic Process
Modification-dependent Protein Catabolic Process
Regulation Of Programmed Cell Death
Protein Polyubiquitination
Cytoskeleton-dependent Cytokinesis
Response To Cobalt Ion
CD40 Receptor Complex
Regulation Of Macroautophagy
Apoptotic Signaling Pathway
Positive Regulation Of Protein Catabolic Process
Signal Transduction
Regulation Of Protein Localization
Cytoplasm
Transferase Activity
Regulation Of Protein Catabolic Process
Golgi Inheritance
Positive Regulation Of Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein-containing Complex
Regulation Of Protein Metabolic Process
Cysteine-type Endopeptidase Activity
DNA Damage Response
Cellular Response To Stress
Positive Regulation Of Execution Phase Of Apoptosis
Positive Regulation Of Protein K48-linked Ubiquitination
Ubiquitin Protein Ligase Binding
Protein Localization To Site Of Double-strand Break
Macromolecule Metabolic Process
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Tagcloud (Intersection)
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