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HTRA2 and CDK1
Number of citations of the paper that reports this interaction (PubMedID
17906618
)
0
Data Source:
BioGRID
(enzymatic study)
HTRA2
CDK1
Description
HtrA serine peptidase 2
cyclin dependent kinase 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Mitochondrion
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Cytoskeleton
Cytoplasmic Side Of Plasma Membrane
Membrane
Mitochondrial Membrane
Protein-containing Complex
CD40 Receptor Complex
Serine-type Endopeptidase Complex
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Endoplasmic Reticulum Membrane
Centrosome
Spindle
Cytosol
Cytoskeleton
Spindle Microtubule
Membrane
Midbody
Extracellular Exosome
Mitotic Spindle
Cyclin A1-CDK1 Complex
Cyclin A2-CDK1 Complex
Cyclin B1-CDK1 Complex
Molecular Function
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Hydrolase Activity
Protein Serine/threonine Kinase Inhibitor Activity
Identical Protein Binding
Unfolded Protein Binding
Ubiquitin Ligase Inhibitor Activity
Nucleotide Binding
Virus Receptor Activity
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Kinase Activity
Transferase Activity
Cyclin Binding
Hsp70 Protein Binding
Histone Kinase Activity
Cyclin-dependent Protein Kinase Activity
Protein Serine Kinase Activity
Biological Process
Proteolysis
Ceramide Metabolic Process
Apoptotic Process
Mitochondrion Organization
Adult Walking Behavior
Adult Locomotory Behavior
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Herbicide
Programmed Cell Death
Protein Autoprocessing
Pentacyclic Triterpenoid Metabolic Process
Protein Catabolic Process
Forebrain Development
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To Interferon-beta
Intracellular Signal Transduction
Mitochondrial Protein Catabolic Process
Regulation Of Multicellular Organism Growth
Positive Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Cell Cycle
Neuron Development
Neuron Apoptotic Process
Cellular Response To Retinoic Acid
Cellular Response To Growth Factor Stimulus
Intrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Positive Regulation Of Execution Phase Of Apoptosis
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Type 2 Mitophagy
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Microtubule Cytoskeleton Organization
DNA Replication
DNA Repair
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
DNA Damage Response
Nuclear Envelope Organization
Mitotic Nuclear Membrane Disassembly
Mitotic G2 DNA Damage Checkpoint Signaling
Centrosome Cycle
Pronuclear Fusion
Response To Toxic Substance
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Schwann Cell Differentiation
Response To Amine
Response To Activity
Cell Migration
Protein Deubiquitination
Peptidyl-threonine Phosphorylation
Chromosome Condensation
Epithelial Cell Differentiation
Protein Localization To Kinetochore
Positive Regulation Of Protein Import Into Nucleus
Response To Hydrogen Peroxide
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Mitotic Cell Cycle Phase Transition
Response To Ethanol
Positive Regulation Of DNA Replication
Regulation Of Embryonic Development
Thymidine Biosynthetic Process
Response To Cadmium Ion
Response To Copper Ion
Symbiont Entry Into Host Cell
Microtubule Polymerization
Fibroblast Proliferation
Rhythmic Process
Response To Axon Injury
Cell Division
Ventricular Cardiac Muscle Cell Development
Positive Regulation Of Cardiac Muscle Cell Proliferation
Cilium Disassembly
Positive Regulation Of Mitotic Sister Chromatid Segregation
Protein-containing Complex Assembly
Cellular Response To Hydrogen Peroxide
ERK1 And ERK2 Cascade
Golgi Disassembly
DNA Strand Resection Involved In Replication Fork Processing
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore
Microtubule Cytoskeleton Organization Involved In Mitosis
DNA Synthesis Involved In Mitotic DNA Replication
Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Protein Localization To Site Of Double-strand Break
Mitotic DNA-templated DNA Replication
Pathways
Mitochondrial protein degradation
Mitochondrial unfolded protein response (UPRmt)
MAPK3 (ERK1) activation
E2F-enabled inhibition of pre-replication complex formation
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdc20 mediated degradation of Cyclin B
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Initiation of Nuclear Envelope (NE) Reformation
Nuclear Pore Complex (NPC) Disassembly
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Depolymerization of the Nuclear Lamina
Anchoring of the basal body to the plasma membrane
MAPK6/MAPK4 signaling
Ovarian tumor domain proteases
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Degradation
Mitotic Prophase
G1/S-Specific Transcription
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Transcriptional regulation by RUNX2
PKR-mediated signaling
Drugs
Indirubin-3'-monoxime
Olomoucine
Hymenialdisine
SU9516
Alvocidib
Alsterpaullone
Seliciclib
AT-7519
Fostamatinib
Avotaciclib
Diseases
Parkinson's disease (PD)
GWAS
Cocaine dependence (
23958962
)
Voxel-wise structural brain imaging measurements in Alzheimer’s disease (
31095298
)
Interacting Genes
41 interacting genes:
ACTA1
ALDH1A2
APC
APP
AREL1
BIRC2
BIRC3
BIRC6
BIRC7
CAD
CCAR2
CDK1
CDK5
CSN1S1
CSN2
DIABLO
EEF1A1
EIF4G1
HSD17B10
IMMT
ITGA7
MAPK11
MAPK12
MAPK13
MAPK14
MAPK3
MUL1
PAG1
PDXDC1
PDXDC2P-NPIPB14P
PEA15
TRIM28
TUBA1A
TUBB
TUBB6
TUBB7P
UBC
USP7
VIM
VPS4B
XIAP
241 interacting genes:
ABL1
ACSL4
ADD1
AKAP12
AKT1
AMPH
APLP2
AR
ARID4A
BARD1
BCL2
BCL2L11
BIRC5
BIRC6
BRCA1
BRCA2
BTG2
BTRC
BUB1
CALD1
CCNA1
CCNA2
CCNB1
CCNB1IP1
CCNB2
CCNE1
CCP110
CD8A
CDC20
CDC25A
CDC25B
CDC25C
CDCA2
CDCA5
CDK7
CDKN1A
CDKN3
CDT1
CEBPA
CENPF
CEP55
CEP63
CHAF1B
CIITA
CIP2A
CKS2
CNOT7
CREB1
CREM
CSN2
CSNK2A1
CSNK2B
CTNNB1
CUL4B
CUX1
CXCR1
DAB2
DCTN6
DNM2
DTL
DUT
E2F1
ECT2
EEF1D
EEF2K
EML3
EPN1
ERCC2
ERCC6L
FANCA
FANCC
FANCG
FBXO5
FEN1
FLNA
FOXM1
FOXO1
FYN
GADD45A
GADD45B
GADD45G
GAS2L3
GATA2
GBF1
GFAP
GOLGA2
GORASP1
H1-0
H1-1
H1-3
H1-5
H2AC4
H2BC3
H4C1
HASPIN
HJURP
HMGA1
HMGA2
HMGB1
HSPA2
HTRA2
ID2
IDH1
IDH2
IL16
IL3RA
IQGAP1
ITGB3
ITPR1
JAK3
KAT5
KHDRBS1
KIF11
KIF20B
KIF26B
KMT2E
KRT18
LATS1
LMNA
LMNB1
LRRK1
LYN
LZTS1
MAP4
MAPK12
MAPT
MBP
MCM2
MCM4
MDM4
MEF2C
MIS18BP1
MISP
MKI67
MLKL
MLST8
MNDA
MYC
MYT1
NCAPD2
NCAPD3
NCAPG
NCAPH
NCL
NDE1
NEDD1
NES
NHERF1
NONO
NPM1
NSFL1C
NUP210
PAK6
PBK
PCM1
PCNA
PIN1
PIP5K1C
PITPNM1
PKMYT1
PLEC
PML
POLA1
POLL
PON1
PPP1R12A
PPP2R1A
PPP2R1B
PPP2R2B
PPP4R2
PPP4R3A
PRC1
PRDX1
PRDX2
PRKAR2A
PSRC1
PTCH1
PTMA
PTPN1
PTPN2
PTPN6
PTTG1
RAB4A
RAB5B
RACGAP1
RAD9A
RANGAP1
RAP1GAP
RB1
RCC1
RELB
REPS2
RGCC
RPA2
RPS3
RPS6KB1
RRM2
RSF1
RUNX1
RUNX2
SAMHD1
SFN
SLBP
SOX2
SP1
SPAG5
SQSTM1
SRC
SSBP1
STK3
STMN1
STMN2
TERF1
TFDP1
TGFBR2
TK1
TLE1
TMPO
TNNC1
TOP2A
TP53
TP53BP1
TP73
TPR
TSC1
TSPYL2
TUBB
UBA1
UBE2A
UBE3A
UHRF2
USP14
USP16
VHL
VIM
WAC
WEE1
XIAP
XPO1
XRCC6
ZBTB16
Entrez ID
27429
983
HPRD ID
05919
00302
Ensembl ID
ENSG00000115317
ENSG00000170312
Uniprot IDs
A0A384MDW9
A0A8Q3SIX7
O43464
B7Z3D6
I6L9I5
P06493
PDB IDs
1LCY
2PZD
5FHT
5M3N
5M3O
5TNY
5TNZ
5TO0
5TO1
5WYN
7VGE
8AUK
8E2K
4Y72
4YC3
4YC6
5HQ0
5LQF
6GU2
6GU3
6GU4
6GU6
6GU7
6TWN
7NJ0
Enriched GO Terms of Interacting Partners
?
Cell Death
Apoptotic Process
Programmed Cell Death
MAP Kinase Activity
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
MAPK Cascade
Regulation Of Cell Cycle
Ubiquitin-protein Transferase Activity
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Transferase Activity
Cysteine-type Endopeptidase Inhibitor Activity
Cytosol
Intracellular Signal Transduction
Ubiquitin Protein Ligase Activity
Protein Kinase Activity
Regulation Of Apoptotic Process
Intracellular Signaling Cassette
Structural Constituent Of Cytoskeleton
Regulation Of Programmed Cell Death
Response To Cytokine
Response To Peptide
Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Regulation Of Inflammatory Response
Acetylcholine Receptor Activator Activity
Cytoplasm
Response To Light Stimulus
Positive Regulation Of Post-translational Protein Modification
Glial Cell Development
Protein Serine Kinase Activity
Post-translational Protein Modification
Regulation Of Post-translational Protein Modification
Nucleotide Binding
P38MAPK Cascade
Protein Modification By Small Protein Conjugation
Regulation Of Protein Metabolic Process
Regulation Of Intracellular Transport
Protein Serine/threonine Kinase Activity
Protein Metabolic Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Growth
Regulation Of Synapse Organization
Response To Radiation
DNA Damage Response
Protein Ubiquitination
Regulation Of Protein Ubiquitination
Regulation Of Developmental Growth
Regulation Of Toll-like Receptor Signaling Pathway
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Protein Modification Process
Regulation Of Cell Cycle
Regulation Of Cell Cycle Process
Cell Division
Nucleus
Cellular Response To Stress
Nucleoplasm
DNA Damage Response
Regulation Of Mitotic Cell Cycle
Organelle Organization
Cytosol
Cytoplasm
Regulation Of Cell Cycle Phase Transition
Chromosome
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Negative Regulation Of Cell Cycle
Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle
Cell Cycle Phase Transition
Intracellular Signal Transduction
Positive Regulation Of Cell Cycle Process
Negative Regulation Of Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Chromosome Organization
DNA Metabolic Process
Response To Stress
Negative Regulation Of Macromolecule Metabolic Process
DNA Repair
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Population Proliferation
Cytoskeleton
Regulation Of DNA Metabolic Process
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Cell Cycle Process
Positive Regulation Of Apoptotic Process
Protein Kinase Binding
Regulation Of Protein Metabolic Process
Regulation Of Cellular Component Organization
Cell Cycle G2/M Phase Transition
Regulation Of Macromolecule Metabolic Process
DNA-binding Transcription Factor Binding
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Intracellular Signal Transduction
G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Cellular Component Assembly
Negative Regulation Of Mitotic Cell Cycle
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