ACTA1 and VIL1

Number of citations of the paper that reports this interaction (PMID 6893424)
121

Data Source:
HPRD (in vitro)

		ACTA1	VIL1
Gene Name		actin, alpha 1, skeletal muscle	villin 1
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Extracellular Vesicular Exosome Blood Microparticle	Ruffle Cytoplasm Microvillus Lamellipodium Filopodium Actin Filament Bundle Filopodium Tip Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding	Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lysophosphatidic Acid Binding Identical Protein Binding Protein Homodimerization Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Actin Filament Binding
	Biological Process	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Cell Growth Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development	Protein Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Shape Response To Bacterium Positive Regulation Of Epithelial Cell Migration Actin Filament Polymerization Actin Filament Depolymerization Positive Regulation Of Cell Migration Epithelial Cell Differentiation Positive Regulation Of Actin Filament Bundle Assembly Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Nucleation Actin Filament Severing Regulation Of Actin Nucleation Actin Filament Capping Cytoplasmic Actin-based Contraction Involved In Cell Motility Regulation Of Wound Healing Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Lamellipodium Morphogenesis
Pathways		Striated Muscle Contraction
Drugs
Diseases
GWAS
Protein-Protein Interactions		107 interactors: ABL1 ABRA ACTR10 ACTR1B ADSS AFAP1 AIF1 AJUBA AMOT CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	6 interactors: ACTA1 ACTG1 JAK3 PLCG1 SRC TEX11
Entrez ID		58	7429
HPRD ID		00030	01898
Ensembl ID		ENSG00000143632
Uniprot IDs		P68133 Q5T8M7	P09327 Q53F91
PDB IDs		1T44	1UNC 3FG7
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Actin Filament-based Movement Muscle Contraction Muscle System Process Cell Projection Organization Organelle Organization Negative Regulation Of Protein Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Cellular Component Assembly Developmental Process Anatomical Structure Morphogenesis Anatomical Structure Development Negative Regulation Of Protein Complex Assembly System Development Actin-mediated Cell Contraction Response To Wounding Locomotion Cell Development Response To External Stimulus Cell Differentiation Wound Healing Multicellular Organismal Development Cell Morphogenesis Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Tissue Development Cell Projection Morphogenesis Chemotaxis Positive Regulation Of Organelle Organization Cell Part Morphogenesis Neuron Development Actin Polymerization Or Depolymerization Blood Coagulation Hemostasis Cell Junction Assembly	Vascular Endothelial Growth Factor Receptor Signaling Pathway Actomyosin Structure Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Regulation Of Immune Response Phagocytosis Fc Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process System Development Immune Response-activating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Multicellular Organismal Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Anatomical Structure Development Axon Guidance Blood Coagulation Locomotion Hemostasis Immune Response Regulation Of Immune System Process Defense Response Immune Response-regulating Signaling Pathway Myofibril Assembly Developmental Process Adherens Junction Organization Axonogenesis Ephrin Receptor Signaling Pathway Negative Regulation Of FasL Biosynthetic Process Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Actin Cytoskeleton Organization Cell Differentiation Positive Regulation Of Immune Response Neuron Projection Morphogenesis Actin Filament-based Process Endocytosis Cell Activation Cell Development Response To External Stimulus Response To Wounding Negative Regulation Of Dendritic Cell Cytokine Production Skeletal Muscle Fiber Adaptation
Tagcloud ?		annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40	2q33 2q34 artificial bcg brazilian exon fn1 il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed visceral
Tagcloud (Difference) ?		annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40	2q33 2q34 artificial bcg brazilian exon fn1 il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed visceral
Tagcloud (Intersection) ?