ACTA1 and AJUBA

Number of citations of the paper that reports this interaction (PMID 12417594)
24

Data Source:
HPRD (in vivo, in vitro)

		ACTA1	AJUBA
Gene Name		actin, alpha 1, skeletal muscle	ajuba LIM protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Extracellular Vesicular Exosome Blood Microparticle	Cytoplasmic MRNA Processing Body Nucleus Transcription Factor Complex Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Lamellipodium
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding Alpha-catenin Binding Actin Filament Binding
	Biological Process	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Cell Growth Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Response To Hypoxia Transcription, DNA-templated Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Lamellipodium Assembly Regulation Of Cell Migration Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Protein Complex Assembly Negative Regulation Of Kinase Activity Cellular Protein Localization Gene Silencing By MiRNA Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Hippo Signaling Regulation Of GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Glycerophospholipid Biosynthetic Process Focal Adhesion Assembly Regulation Of Cellular Response To Hypoxia Positive Regulation Of Gene Silencing By MiRNA
Pathways		Striated Muscle Contraction	G2/M Transition Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328)
Protein-Protein Interactions		107 interactors: ABL1 ABRA ACTR10 ACTR1B ADSS AFAP1 AIF1 AJUBA AMOT CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	10 interactors: ACTA1 AURKAIP1 AURKB BCAR1 CTNNA1 GFI1B GRB2 LATS2 LCK SLC1A2
Entrez ID		58	84962
HPRD ID		00030	16426
Ensembl ID		ENSG00000143632	ENSG00000129474
Uniprot IDs		P68133 Q5T8M7	Q96IF1
PDB IDs		1T44
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Actin Filament-based Movement Muscle Contraction Muscle System Process Cell Projection Organization Organelle Organization Negative Regulation Of Protein Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Cellular Component Assembly Developmental Process Anatomical Structure Morphogenesis Anatomical Structure Development Negative Regulation Of Protein Complex Assembly System Development Actin-mediated Cell Contraction Response To Wounding Locomotion Cell Development Response To External Stimulus Cell Differentiation Wound Healing Multicellular Organismal Development Cell Morphogenesis Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Tissue Development Cell Projection Morphogenesis Chemotaxis Positive Regulation Of Organelle Organization Cell Part Morphogenesis Neuron Development Actin Polymerization Or Depolymerization Blood Coagulation Hemostasis Cell Junction Assembly	Aging Response To Hormone Response To Wounding Response To Organonitrogen Compound Response To Organic Substance Cellular Response To Organonitrogen Compound Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Abiotic Stimulus Organ Development Organelle Organization Platelet Activation Cellular Response To Hormone Stimulus Multicellular Organismal Development Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway B Cell Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Actin Filament Organization Developmental Process Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway System Development Regulation Of Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Costimulation Response To External Stimulus Negative Regulation Of Cell Division Cellular Response To Organic Substance Blood Coagulation Cell Division Regulation Of Cellular Component Organization Hemostasis Response To Radiation Negative Regulation Of Cell Cycle Response To Peptide Hormone Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Skeletal Muscle Fiber Adaptation Negative Regulation Of Integrin-mediated Signaling Pathway Cellular Response To Stimulus Response To Peptide T Cell Receptor Signaling Pathway Anatomical Structure Development Protein Heterooligomerization Histone H3-S28 Phosphorylation D-aspartate Import
Tagcloud ?		annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40	belongs carp cdna connect contained cytoplasm cytoskeleton entire extracellular frame gcrv grass hybrid immediately immunoprecipitation inducible ip jx01 lim location matrix ns26 orf overlap polypeptide reading responding sub
Tagcloud (Difference) ?		annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40	belongs carp cdna connect contained cytoplasm cytoskeleton entire extracellular frame gcrv grass hybrid immediately immunoprecipitation inducible ip jx01 lim location matrix ns26 orf overlap polypeptide reading responding sub
Tagcloud (Intersection) ?