ACTA1 and MYL1

Number of citations of the paper that reports this interaction (PMID 11707283)
2

Data Source:
HPRD (in vitro)

		ACTA1	MYL1
Gene Name		actin, alpha 1, skeletal muscle	myosin, light chain 1, alkali; skeletal, fast
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Extracellular Vesicular Exosome Blood Microparticle	Cytosol Muscle Myosin Complex Myofibril Sarcomere
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding	Calcium Ion Binding Structural Constituent Of Muscle
	Biological Process	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Cell Growth Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development	Muscle Contraction Muscle Filament Sliding Cardiac Muscle Contraction
Pathways		Striated Muscle Contraction	Striated Muscle Contraction
Drugs
Diseases
GWAS
Protein-Protein Interactions		107 interactors: ABL1 ABRA ACTR10 ACTR1B ADSS AFAP1 AIF1 AJUBA AMOT CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	4 interactors: ACTA1 ACTA2 APP EPB41
Entrez ID		58	4632
HPRD ID		00030	01180
Ensembl ID		ENSG00000143632	ENSG00000168530
Uniprot IDs		P68133 Q5T8M7	P05976
PDB IDs		1T44
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Actin Filament-based Movement Muscle Contraction Muscle System Process Cell Projection Organization Organelle Organization Negative Regulation Of Protein Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Cellular Component Assembly Developmental Process Anatomical Structure Morphogenesis Anatomical Structure Development Negative Regulation Of Protein Complex Assembly System Development Actin-mediated Cell Contraction Response To Wounding Locomotion Cell Development Response To External Stimulus Cell Differentiation Wound Healing Multicellular Organismal Development Cell Morphogenesis Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Tissue Development Cell Projection Morphogenesis Chemotaxis Positive Regulation Of Organelle Organization Cell Part Morphogenesis Neuron Development Actin Polymerization Or Depolymerization Blood Coagulation Hemostasis Cell Junction Assembly	Regulation Of Protein Binding Cell Growth Skeletal Muscle Fiber Adaptation Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Muscle Contraction Regulation Of Binding Muscle System Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Glomerular Mesangial Cell Development Blood Circulation Axon Choice Point Recognition Skeletal Muscle Thin Filament Assembly Mesangial Cell Development Renal Interstitial Fibroblast Development Skeletal Myofibril Assembly Neuron Remodeling Skeletal Muscle Adaptation Cell Development Response To External Stimulus Vascular Smooth Muscle Contraction Growth Cellular Copper Ion Homeostasis Glomerulus Vasculature Development Copper Ion Homeostasis Suckling Behavior Actin Cytoskeleton Organization Skeletal Muscle Fiber Development Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cortical Actin Cytoskeleton Organization Actin Filament-based Process Cortical Cytoskeleton Organization Myotube Cell Development Neuron Maturation MRNA Polyadenylation Response To Lithium Ion Regulation Of Epidermal Growth Factor-activated Receptor Activity Vasoconstriction Actin-myosin Filament Sliding Muscle Filament Sliding Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Cell Differentiation Involved In Kidney Development Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Organ Development Actin-mediated Cell Contraction
Tagcloud ?		annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40	acz advantages alleles beyond cassette ce cre disadvantages embryogenesis extends foreseeable immediate inducible knock knocked myf6 myod1 myog myogenic pax3 questions r26r rendering replacing reporter resource skeletal tamoxifen tightly
Tagcloud (Difference) ?		annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40	acz advantages alleles beyond cassette ce cre disadvantages embryogenesis extends foreseeable immediate inducible knock knocked myf6 myod1 myog myogenic pax3 questions r26r rendering replacing reporter resource skeletal tamoxifen tightly
Tagcloud (Intersection) ?