HTRA2 and ALDH1A2

Number of citations of the paper that reports this interaction (PubMedID 17266347)
0

Data Source:
BioGRID (unspecified method)

		HTRA2	ALDH1A2
Description		HtrA serine peptidase 2	aldehyde dehydrogenase 1 family member A2
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GO Annotations	Cellular Component	Chromatin Nucleus Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Membrane Protein-containing Complex CD40 Receptor Complex Serine-type Endopeptidase Complex	Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Protein Serine/threonine Kinase Inhibitor Activity Identical Protein Binding Unfolded Protein Binding Ubiquitin Ligase Inhibitor Activity	Retinal Dehydrogenase (NAD+) Activity 3-chloroallyl Aldehyde Dehydrogenase Activity Aldehyde Dehydrogenase (NAD+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Retinal Binding
	Biological Process	Proteolysis Ceramide Metabolic Process Apoptotic Process Mitochondrion Organization Adult Walking Behavior Adult Locomotory Behavior Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Herbicide Programmed Cell Death Protein Autoprocessing Pentacyclic Triterpenoid Metabolic Process Protein Catabolic Process Forebrain Development Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Interferon-beta Intracellular Signal Transduction Mitochondrial Protein Catabolic Process Regulation Of Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Cycle Neuron Development Neuron Apoptotic Process Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Type 2 Mitophagy Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Blood Vessel Development Kidney Development Liver Development Retinoic Acid Biosynthetic Process Heart Morphogenesis Aldehyde Metabolic Process Lipid Metabolic Process Vitamin A Metabolic Process Midgut Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Determination Of Bilateral Symmetry Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Positive Regulation Of Gene Expression Neural Crest Cell Development Morphogenesis Of Embryonic Epithelium Neural Tube Development Pituitary Gland Development Neuron Differentiation Lung Development Embryonic Limb Morphogenesis Forebrain Development Hindbrain Development Pancreas Development Embryonic Camera-type Eye Development Response To Estradiol Response To Retinoic Acid Response To Vitamin A Response To Cytokine Embryonic Forelimb Morphogenesis Ureter Maturation Retinol Metabolic Process Retinoic Acid Metabolic Process Retinal Metabolic Process 9-cis-retinoic Acid Biosynthetic Process Camera-type Eye Development Positive Regulation Of Apoptotic Process Retinoic Acid Receptor Signaling Pathway Embryonic Digestive Tract Development Cardiac Muscle Tissue Development Protein Homotetramerization Face Development Cellular Response To Retinoic Acid Regulation Of Vascular Endothelial Cell Proliferation
Pathways		Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)	RA biosynthesis pathway
Drugs			NADH Vitamin A Tretinoin
Diseases		Parkinson's disease (PD)
GWAS			Barrett's esophagus ( 27527254) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Brain morphology (MOSTest) ( 32665545) Cholesterol ( 31902109) Diisocyanate-induced asthma ( 25918132) Eosinophil count ( 32888494) HDL cholesterol ( 30275531 28270201) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hypertension ( 19609347) Ischemic stroke ( 26089329) LDL cholesterol ( 30275531) Lipoprotein (a) levels ( 33730874) Low density lipoprotein cholesterol levels ( 32154731) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Low HDL-cholesterol levels ( 31910446) Lymphocyte count ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Osteoarthritis (hand, severe) ( 24728293) Red blood cell count ( 32888494) Serum metabolite levels ( 33031748) Small cell lung carcinoma ( 28604730) Stroke ( 26089329) Total cholesterol levels ( 30275531) Total cholesterol levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Triglyceride levels ( 32154731) Uncontrolled blood pressure in combination therapy (beta blocker and thiazide diuretic) ( 29097388)
Interacting Genes		41 interacting genes: ACTA1 ALDH1A2 APC APP AREL1 BIRC2 BIRC3 BIRC6 BIRC7 CAD CCAR2 CDK1 CDK5 CSN1S1 CSN2 DIABLO EEF1A1 EIF4G1 HSD17B10 IMMT ITGA7 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MUL1 PAG1 PDXDC1 PDXDC2P-NPIPB14P PEA15 TRIM28 TUBA1A TUBB TUBB6 TUBB7P UBC USP7 VIM VPS4B XIAP	3 interacting genes: HTRA2 OGT UBE3A
Entrez ID		27429	8854
HPRD ID		05919	04733
Ensembl ID		ENSG00000115317	ENSG00000128918
Uniprot IDs		A0A384MDW9 A0A8Q3SIX7 O43464	O94788
PDB IDs		1LCY 2PZD 5FHT 5M3N 5M3O 5TNY 5TNZ 5TO0 5TO1 5WYN 7VGE 8AUK 8E2K	4X2Q 6ALJ 6B5G 6B5H 6B5I
Enriched GO Terms of Interacting Partners?		Cell Death Apoptotic Process Programmed Cell Death MAP Kinase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process MAPK Cascade Regulation Of Cell Cycle Ubiquitin-protein Transferase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Cytosol Intracellular Signal Transduction Ubiquitin Protein Ligase Activity Protein Kinase Activity Regulation Of Apoptotic Process Intracellular Signaling Cassette Structural Constituent Of Cytoskeleton Regulation Of Programmed Cell Death Response To Cytokine Response To Peptide Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Inflammatory Response Acetylcholine Receptor Activator Activity Cytoplasm Response To Light Stimulus Positive Regulation Of Post-translational Protein Modification Glial Cell Development Protein Serine Kinase Activity Post-translational Protein Modification Regulation Of Post-translational Protein Modification Nucleotide Binding P38MAPK Cascade Protein Modification By Small Protein Conjugation Regulation Of Protein Metabolic Process Regulation Of Intracellular Transport Protein Serine/threonine Kinase Activity Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Growth Regulation Of Synapse Organization Response To Radiation DNA Damage Response Protein Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Developmental Growth Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Modification Process	Positive Regulation Of TOR Signaling Sperm Entry Positive Regulation Of TORC1 Signaling Regulation Of TORC1 Signaling Regulation Of Protein Localization Positive Regulation Of Golgi Lumen Acidification Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Pentacyclic Triterpenoid Metabolic Process Regulation Of TOR Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteolysis Mitochondrial Membrane Protein Processing Negative Regulation Of Type 2 Mitophagy Regulation Of Protein Ubiquitination Negative Regulation Of Signal Transduction Rhythmic Process Regulation Of Golgi Lumen Acidification Negative Regulation Of Cell Communication Regulation Of Post-translational Protein Modification Cellular Response To Nutrient Levels Negative Regulation Of Signaling Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cellular PH Reduction Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Response To Herbicide Positive Regulation Of Protein Localization To Lysosome Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Protein Maturation Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Proteolysis Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Transcription By Glucose Prostate Gland Growth Mitochondrial Protein Catabolic Process Serine-type Endopeptidase Complex Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand NSL Complex CD40 Receptor Complex Progesterone Receptor Signaling Pathway Ubiquitin Ligase Inhibitor Activity
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