HTRA2 and CSN2

Number of citations of the paper that reports this interaction (PubMedID 10971580)
0

Data Source:
HPRD (in vitro)

		HTRA2	CSN2
Description		HtrA serine peptidase 2	casein beta
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Membrane Protein-containing Complex CD40 Receptor Complex Serine-type Endopeptidase Complex	Extracellular Region Extracellular Space
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Protein Serine/threonine Kinase Inhibitor Activity Identical Protein Binding Unfolded Protein Binding Ubiquitin Ligase Inhibitor Activity	Enzyme Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding
	Biological Process	Proteolysis Ceramide Metabolic Process Apoptotic Process Mitochondrion Organization Adult Walking Behavior Adult Locomotory Behavior Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Herbicide Programmed Cell Death Protein Autoprocessing Pentacyclic Triterpenoid Metabolic Process Protein Catabolic Process Forebrain Development Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Interferon-beta Intracellular Signal Transduction Mitochondrial Protein Catabolic Process Regulation Of Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Cycle Neuron Development Neuron Apoptotic Process Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Type 2 Mitophagy Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Calcium Ion Transport Lactation
Pathways		Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)	Nuclear signaling by ERBB4 Developmental Lineage of Mammary Gland Alveolar Cells
Drugs
Diseases		Parkinson's disease (PD)
GWAS
Interacting Genes		41 interacting genes: ACTA1 ALDH1A2 APC APP AREL1 BIRC2 BIRC3 BIRC6 BIRC7 CAD CCAR2 CDK1 CDK5 CSN1S1 CSN2 DIABLO EEF1A1 EIF4G1 HSD17B10 IMMT ITGA7 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MUL1 PAG1 PDXDC1 PDXDC2P-NPIPB14P PEA15 TRIM28 TUBA1A TUBB TUBB6 TUBB7P UBC USP7 VIM VPS4B XIAP	18 interacting genes: AURKA CDC42 CDK1 CELA1 CSN3 CSNK2A1 CSNK2B FHL2 GRB2 HTRA2 NEK1 NEK2 NEK9 NFYC PLK1 RAC1 TOLLIP UBQLN2
Entrez ID		27429	1447
HPRD ID		05919	00281
Ensembl ID		ENSG00000115317	ENSG00000135222
Uniprot IDs		A0A384MDW9 A0A8Q3SIX7 O43464	P05814 W5RWE1
PDB IDs		1LCY 2PZD 5FHT 5M3N 5M3O 5TNY 5TNZ 5TO0 5TO1 5WYN 7VGE 8AUK 8E2K
Enriched GO Terms of Interacting Partners?		Cell Death Apoptotic Process Programmed Cell Death MAP Kinase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process MAPK Cascade Regulation Of Cell Cycle Ubiquitin-protein Transferase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Cytosol Intracellular Signal Transduction Ubiquitin Protein Ligase Activity Protein Kinase Activity Regulation Of Apoptotic Process Intracellular Signaling Cassette Structural Constituent Of Cytoskeleton Regulation Of Programmed Cell Death Response To Cytokine Response To Peptide Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Inflammatory Response Acetylcholine Receptor Activator Activity Cytoplasm Response To Light Stimulus Positive Regulation Of Post-translational Protein Modification Glial Cell Development Protein Serine Kinase Activity Post-translational Protein Modification Regulation Of Post-translational Protein Modification Nucleotide Binding P38MAPK Cascade Protein Modification By Small Protein Conjugation Regulation Of Protein Metabolic Process Regulation Of Intracellular Transport Protein Serine/threonine Kinase Activity Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Growth Regulation Of Synapse Organization Response To Radiation DNA Damage Response Protein Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Developmental Growth Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Modification Process	Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Phosphorylation Centrosome Centrosome Separation Protein Kinase Activity Protein Phosphorylation Midbody Regulation Of Attachment Of Spindle Microtubules To Kinetochore Kinase Activity Regulation Of Proteasomal Protein Catabolic Process Protein Localization To Site Of Double-strand Break Spindle Midzone Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Cell Division Protein Kinase Binding Regulation Of Cell Cycle Regulation Of Mitotic Nuclear Division Wnt Signaling Pathway Organelle Organization Positive Regulation Of Organelle Organization Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Mitotic Cell Cycle Spindle Microtubule Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Organelle Organization Mitotic Cell Cycle Regulation Of Nuclear Division Centrosome Cycle Signal Transduction In Response To DNA Damage Nucleotide Binding G2/M Transition Of Mitotic Cell Cycle G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Cell Cycle Cell Cycle G2/M Phase Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Cytoskeleton Organization Ventricular Cardiac Muscle Cell Development Thioesterase Binding Regulation Of Cellular Component Organization Mitotic Nuclear Membrane Disassembly Cytoskeleton Cilium Disassembly Positive Regulation Of Protein Catabolic Process Cytosol Regulation Of Cell Cycle Process
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