ACTA1 and ABRA

Number of citations of the paper that reports this interaction (PubMedID 17194709)
0

Data Source:
BioGRID (two hybrid)

		ACTA1	ABRA
Description		actin alpha 1, skeletal muscle	actin binding Rho activating protein
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Extracellular Space Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle	Cytoplasm Cytoskeleton Plasma Membrane Actin Cytoskeleton Myofibril Sarcomere
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity Myosin Binding ADP Binding	Actin Binding Protein Binding
	Biological Process	Muscle Contraction Positive Regulation Of Gene Expression Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Development Mesenchyme Migration	Transcription By RNA Polymerase II Protein Import Into Nucleus Protein Transport Actin Cytoskeleton Organization Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Striated Muscle Contraction Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases		Cap myopathy Congenital fiber type disproportion (CFTD) Nemaline myopathy
GWAS			Dental caries ( 23259602) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Intraocular pressure ( 30054594 31959993) Metabolite levels ( 23823483)
Interacting Genes		115 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 LINC00624 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	6 interacting genes: ABLIM2 ACTA1 ACTB ACTC1 PPP1R18 TRAPPC2
Entrez ID		58	137735
HPRD ID		00030	11608
Ensembl ID		ENSG00000143632	ENSG00000174429
Uniprot IDs		P68133	Q8N0Z2
PDB IDs		7RNS 7RNU 7RNV 9DUU 9DUV
Enriched GO Terms of Interacting Partners?		Actin Binding Actin Filament Binding Cytoskeleton Actin Cytoskeleton Actin Filament-based Process Cytoplasm Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Actin Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytosol Regulation Of Cellular Component Size Regulation Of Protein-containing Complex Assembly Cell Cortex Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Lamellipodium Ruffle Actin Filament Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Cortical Actin Cytoskeleton Positive Regulation Of Cellular Component Biogenesis Actin Polymerization Or Depolymerization Regulation Of Biological Quality Anchoring Junction Organelle Organization Ruffle Membrane Positive Regulation Of Protein-containing Complex Assembly Cell Projection Filopodium Regulation Of Cell Shape Muscle System Process Negative Regulation Of Actin Filament Depolymerization Regulation Of Protein Localization	Actin Filament Actin Cytoskeleton Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Blood Microparticle Lamellipodium Myosin Binding Sarcomere Filopodium Cell Body Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Structural Constituent Of Cytoskeleton Cytoskeleton Regulation Of Norepinephrine Uptake Transporter Regulator Activity Regulation Of Transepithelial Transport Protein Localization To Adherens Junction Dense Body Cytoplasmic Actin-based Contraction Involved In Cell Motility Muscle Contraction Morphogenesis Of A Polarized Epithelium Structural Constituent Of Postsynaptic Actin Cytoskeleton Striated Muscle Thin Filament Muscle System Process Actin Filament Organization BBAF Complex Tat Protein Binding Nitric-oxide Synthase Regulator Activity Postsynaptic Actin Cytoskeleton Cytoskeleton Organization Cytoplasm Brahma Complex Nitric-oxide Synthase Binding Apical Protein Localization RSC-type Complex Adherens Junction Assembly NpBAF Complex GBAF Complex Cellular Component Assembly Cardiac Myofibril Assembly TRAPPII Protein Complex TRAPP Complex TRAPPIII Protein Complex Organelle Organization NBAF Complex Postsynaptic Actin Cytoskeleton Organization Actin-myosin Filament Sliding Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction
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