ACTA1 and ABRA

Number of citations of the paper that reports this interaction (PMID 17194709)
13

Data Source:
BioGRID (two hybrid)

		ACTA1	ABRA
Gene Name		actin, alpha 1, skeletal muscle	actin-binding Rho activating protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Extracellular Vesicular Exosome Blood Microparticle	Plasma Membrane Actin Cytoskeleton Sarcomere
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding	Transcription Coactivator Activity Actin Binding
	Biological Process	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Cell Growth Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development	Protein Import Into Nucleus, Translocation Transcription, DNA-templated Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways		Striated Muscle Contraction
Drugs
Diseases
GWAS			Dental caries ( 23259602)
Protein-Protein Interactions		107 interactors: ABL1 ABRA ACTR10 ACTR1B ADSS AFAP1 AIF1 AJUBA AMOT CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	4 interactors: ABLIM2 ACTA1 ACTB ACTC1
Entrez ID		58	137735
HPRD ID		00030	11608
Ensembl ID		ENSG00000143632	ENSG00000174429
Uniprot IDs		P68133 Q5T8M7	Q8N0Z2
PDB IDs		1T44
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Actin Filament-based Movement Muscle Contraction Muscle System Process Cell Projection Organization Organelle Organization Negative Regulation Of Protein Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Cellular Component Assembly Developmental Process Anatomical Structure Morphogenesis Anatomical Structure Development Negative Regulation Of Protein Complex Assembly System Development Actin-mediated Cell Contraction Response To Wounding Locomotion Cell Development Response To External Stimulus Cell Differentiation Wound Healing Multicellular Organismal Development Cell Morphogenesis Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Tissue Development Cell Projection Morphogenesis Chemotaxis Positive Regulation Of Organelle Organization Cell Part Morphogenesis Neuron Development Actin Polymerization Or Depolymerization Blood Coagulation Hemostasis Cell Junction Assembly	Skeletal Muscle Thin Filament Assembly Skeletal Myofibril Assembly Muscle Filament Sliding Actin-myosin Filament Sliding Movement Of Cell Or Subcellular Component Actin-mediated Cell Contraction Cell Development Actin Filament-based Movement Myofibril Assembly Actin Cytoskeleton Organization Actin Filament-based Process Anatomical Structure Morphogenesis Actomyosin Structure Organization Striated Muscle Cell Development Muscle Cell Development Skeletal Muscle Fiber Adaptation Organelle Organization Cytoskeleton Organization Cell Differentiation Muscle Contraction Striated Muscle Cell Differentiation Muscle System Process Muscle Organ Development Actin Filament Organization System Development Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Tissue Development Skeletal Muscle Adaptation Axon Guidance Multicellular Organismal Development Response To External Stimulus Anatomical Structure Development Cellular Component Assembly Organelle Assembly Muscle Structure Development Axonogenesis Developmental Process Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cardiac Myofibril Assembly Skeletal Muscle Fiber Development Neuron Projection Morphogenesis Myotube Cell Development Response To Lithium Ion Cell Morphogenesis Involved In Differentiation Substantia Nigra Development Platelet Aggregation Neuron Projection Development
Tagcloud ?		annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40	angiitis angiopathy caa characteristically complicating cortico e4 flair gadolinium granulomatous headaches hyperintensities immunosuppressant immunosuppressants microbleeds obviating pcnsv recur responds scant steroids subcortical superimposed swi t2w transmural treatable vasculitis walls
Tagcloud (Difference) ?		annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40	angiitis angiopathy caa characteristically complicating cortico e4 flair gadolinium granulomatous headaches hyperintensities immunosuppressant immunosuppressants microbleeds obviating pcnsv recur responds scant steroids subcortical superimposed swi t2w transmural treatable vasculitis walls
Tagcloud (Intersection) ?