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HTRA2 and DIABLO
Number of citations of the paper that reports this interaction (PubMedID
32877691
)
0
Data Source:
BioGRID
(proximity labelling technology)
HPRD
(in vivo)
HTRA2
DIABLO
Description
HtrA serine peptidase 2
diablo IAP-binding mitochondrial protein
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Mitochondrion
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Cytoskeleton
Cytoplasmic Side Of Plasma Membrane
Membrane
Mitochondrial Membrane
Protein-containing Complex
CD40 Receptor Complex
Serine-type Endopeptidase Complex
Cytoplasm
Mitochondrion
Mitochondrial Intermembrane Space
Cytosol
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Molecular Function
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Hydrolase Activity
Protein Serine/threonine Kinase Inhibitor Activity
Identical Protein Binding
Unfolded Protein Binding
Ubiquitin Ligase Inhibitor Activity
Protein Binding
Biological Process
Proteolysis
Ceramide Metabolic Process
Apoptotic Process
Mitochondrion Organization
Adult Walking Behavior
Adult Locomotory Behavior
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Herbicide
Programmed Cell Death
Protein Autoprocessing
Pentacyclic Triterpenoid Metabolic Process
Protein Catabolic Process
Forebrain Development
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To Interferon-beta
Intracellular Signal Transduction
Mitochondrial Protein Catabolic Process
Regulation Of Multicellular Organism Growth
Positive Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Cell Cycle
Neuron Development
Neuron Apoptotic Process
Cellular Response To Retinoic Acid
Cellular Response To Growth Factor Stimulus
Intrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Positive Regulation Of Execution Phase Of Apoptosis
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Type 2 Mitophagy
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Apoptotic Process
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Positive Regulation Of Apoptotic Process
Neuron Apoptotic Process
Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Pathways
Mitochondrial protein degradation
Mitochondrial unfolded protein response (UPRmt)
Release of apoptotic factors from the mitochondria
SMAC (DIABLO) binds to IAPs
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC, XIAP-regulated apoptotic response
Regulation of the apoptosome activity
Drugs
Phenethyl Isothiocyanate
Diseases
Parkinson's disease (PD)
GWAS
A body shape index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
41 interacting genes:
ACTA1
ALDH1A2
APC
APP
AREL1
BIRC2
BIRC3
BIRC6
BIRC7
CAD
CCAR2
CDK1
CDK5
CSN1S1
CSN2
DIABLO
EEF1A1
EIF4G1
HSD17B10
IMMT
ITGA7
MAPK11
MAPK12
MAPK13
MAPK14
MAPK3
MUL1
PAG1
PDXDC1
PDXDC2P-NPIPB14P
PEA15
TRIM28
TUBA1A
TUBB
TUBB6
TUBB7P
UBC
USP7
VIM
VPS4B
XIAP
45 interacting genes:
AGTRAP
APOC2
APOC4
AREL1
ARL6IP1
ARNT
BEX3
BIRC2
BIRC3
BIRC5
BIRC6
BIRC7
CASP9
CDC34
CMTM4
DERL2
DGAT2L6
DHRS1
E2F1
EEF1A1
FADS6
FKBP7
HSD17B13
HSFX1
HTRA2
LTBR
MAML2
MICOS13
MPC2
NR4A1
RHBDD2
RMDN2
SEC22A
SFT2D1
SLC17A9
SLC25A47
SLC66A2
STMN4
SYP
TIMMDC1
UBC
UBE2K
UFM1
XIAP
ZNF746
Entrez ID
27429
56616
HPRD ID
05919
05560
Ensembl ID
ENSG00000115317
ENSG00000184047
Uniprot IDs
A0A384MDW9
A0A8Q3SIX7
O43464
A0A0S2Z5P6
A0A0S2Z5U7
K7X1S0
Q502X2
Q9NR28
PDB IDs
1LCY
2PZD
5FHT
5M3N
5M3O
5TNY
5TNZ
5TO0
5TO1
5WYN
7VGE
8AUK
8E2K
1FEW
1G3F
1G73
1OXQ
1TW6
1XB0
1XB1
3D9U
3UIH
3UIJ
4TX5
6JX6
8ATO
8AUW
8E2I
8E2J
Enriched GO Terms of Interacting Partners
?
Cell Death
Apoptotic Process
Programmed Cell Death
MAP Kinase Activity
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
MAPK Cascade
Regulation Of Cell Cycle
Ubiquitin-protein Transferase Activity
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Transferase Activity
Cysteine-type Endopeptidase Inhibitor Activity
Cytosol
Intracellular Signal Transduction
Ubiquitin Protein Ligase Activity
Protein Kinase Activity
Regulation Of Apoptotic Process
Intracellular Signaling Cassette
Structural Constituent Of Cytoskeleton
Regulation Of Programmed Cell Death
Response To Cytokine
Response To Peptide
Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Regulation Of Inflammatory Response
Acetylcholine Receptor Activator Activity
Cytoplasm
Response To Light Stimulus
Positive Regulation Of Post-translational Protein Modification
Glial Cell Development
Protein Serine Kinase Activity
Post-translational Protein Modification
Regulation Of Post-translational Protein Modification
Nucleotide Binding
P38MAPK Cascade
Protein Modification By Small Protein Conjugation
Regulation Of Protein Metabolic Process
Regulation Of Intracellular Transport
Protein Serine/threonine Kinase Activity
Protein Metabolic Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Growth
Regulation Of Synapse Organization
Response To Radiation
DNA Damage Response
Protein Ubiquitination
Regulation Of Protein Ubiquitination
Regulation Of Developmental Growth
Regulation Of Toll-like Receptor Signaling Pathway
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Protein Modification Process
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Cell Death
Apoptotic Process
Programmed Cell Death
Ubiquitin-protein Transferase Activity
Cysteine-type Endopeptidase Inhibitor Activity
Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Positive Regulation Of Post-translational Protein Modification
Regulation Of Post-translational Protein Modification
Cellular Response To Interferon-beta
Macromolecule Catabolic Process
Negative Regulation Of Apoptotic Process
Protein Modification By Small Protein Conjugation
Ubiquitin Conjugating Enzyme Activity
Negative Regulation Of Programmed Cell Death
Response To Interferon-beta
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Protein Ubiquitination
Signal Recognition Particle Binding
Peptidase Inhibitor Activity
Post-translational Protein Modification
Ubiquitin Protein Ligase Activity
CD40 Receptor Complex
Proteolysis Involved In Protein Catabolic Process
Positive Regulation Of Protein Modification Process
Identical Protein Binding
Canonical NF-kappaB Signal Transduction
Organophosphate Ester Transport
Regulation Of Inflammatory Response
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Protein Polyubiquitination
Proteolysis
Positive Regulation Of Protein Polyubiquitination
Response To Hypoxia
Negative Regulation Of Necroptotic Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Protein Catabolic Process
Regulation Of RIG-I Signaling Pathway
Very-low-density Lipoprotein Particle
Negative Regulation Of Programmed Necrotic Cell Death
Response To Decreased Oxygen Levels
Protein Binding
Positive Regulation Of Execution Phase Of Apoptosis
Regulation Of Protein Modification Process
Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Regulation Of Canonical NF-kappaB Signal Transduction
Nucleotide Transmembrane Transport
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Tagcloud (Intersection)
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