HTRA2 and BIRC3

Number of citations of the paper that reports this interaction (PMID 11583623)
150

Data Source:
HPRD (in vivo)

		HTRA2	BIRC3
Gene Name		HtrA serine peptidase 2	baculoviral IAP repeat containing 3
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Membrane CD40 Receptor Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Spindle Microtubule Membrane Raft
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Unfolded Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Proteolysis Ceramide Metabolic Process Mitochondrion Organization Adult Walking Behavior Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Herbicide Positive Regulation Of Cell Death Protein Autoprocessing Pentacyclic Triterpenoid Metabolic Process Forebrain Development Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Interferon-beta Regulation Of Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Catabolic Process Negative Regulation Of Cell Cycle Neuron Development Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Execution Phase Of Apoptosis Negative Regulation Of Neuron Death Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrion Degradation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Spermatogenesis Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Regulation Of RIG-I Signaling Pathway Negative Regulation Of Phosphorylation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Innate Immune Response Regulation Of Inflammatory Response Protein Heterooligomerization Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Necroptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Mitotic Spindle Assembly Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Activated TLR4 signalling Toll-Like Receptors Cascades Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88-independent cascade Innate Immune System
Drugs
Diseases
GWAS			MRI atrophy measures ( 21116278) Prostate cancer ( 23535732)
Protein-Protein Interactions		37 interactors: ACTA1 ALDH1A2 APC APP AREL1 BIRC2 BIRC3 BIRC6 BIRC7 CAD CCAR2 CDK1 CDK5 CSN1S1 CSN2 DIABLO EEF1A1 EIF4G1 HSD17B10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 PAG1 PDXDC1 PDXDC2P PEA15 TRIM28 TUBA1A TUBB TUBB6 TUBB7P USP7 VIM VPS4B XIAP	37 interactors: BCL10 BIRC5 CASP3 CASP7 CASP9 CD40 CYFIP2 DIABLO DZIP3 GSPT1 HAX1 HTRA2 IKBKE IKBKG MAP3K14 MBTPS1 PACS2 RAF1 RCHY1 RIPK1 RIPK2 RIPK3 RIPK4 SNX7 SPHK1 SUMO1 TRAF1 TRAF2 TRAF3 UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2Q2 UBE2V1 USP19
Entrez ID		27429	330
HPRD ID		05919	03426
Ensembl ID		ENSG00000115317	ENSG00000023445
Uniprot IDs		O43464	Q13489
PDB IDs		1LCY 2PZD	2UVL 3EB5 3EB6 3M0A 3M0D
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Proteolysis Cellular Protein Metabolic Process Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Proteolysis Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Protein Processing Regulation Of Protein Metabolic Process Protein Metabolic Process Regulation Of Protein Processing Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Toll-like Receptor Signaling Pathway Response To Stimulus Regulation Of Cell Death Cellular Response To Stimulus MAPK Cascade Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To Stress Regulation Of Innate Immune Response Activation Of Innate Immune Response Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Peptidase Activity Cellular Response To Stress Cellular Protein Modification Process Signal Transduction By Phosphorylation Response To Organic Substance Cellular Response To DNA Damage Stimulus Positive Regulation Of Innate Immune Response Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Stress-activated MAPK Cascade Peptidyl-serine Phosphorylation Stress-activated Protein Kinase Signaling Cascade Neurotrophin Signaling Pathway	Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Activation Of Innate Immune Response Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Immune System Process Apoptotic Process Programmed Cell Death Regulation Of Immune Response Cell Death Death Innate Immune Response Regulation Of Proteolysis Positive Regulation Of Immune System Process Regulation Of Cysteine-type Endopeptidase Activity Defense Response Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Immune Response Positive Regulation Of Cellular Metabolic Process Immune Response Cellular Response To Stress Positive Regulation Of Catalytic Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Response To Stress Positive Regulation Of Endopeptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Peptidase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Death Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Immune System Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Tagcloud ?		betal concerned decreasing designed ec endometrial er estrogen heterogeneous hnrnp hnrnps ihc immunohistochemisty insight intimate investigation link nucleus performs pharmaceutical possesses prognosis real recurrence recurrent ribonucleoprotein shows towards transformer	binet biology briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations myd88 notch1 persons predominately sf3b1 stratification tp53 un
Tagcloud (Difference) ?		betal concerned decreasing designed ec endometrial er estrogen heterogeneous hnrnp hnrnps ihc immunohistochemisty insight intimate investigation link nucleus performs pharmaceutical possesses prognosis real recurrence recurrent ribonucleoprotein shows towards transformer	binet biology briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations myd88 notch1 persons predominately sf3b1 stratification tp53 un
Tagcloud (Intersection) ?