ACTA1 and COTL1

Number of citations of the paper that reports this interaction (PubMedID 11583571)
31

Data Source:
HPRD (in vitro, in vivo)

		ACTA1	COTL1
Description		actin alpha 1, skeletal muscle	coactosin like F-actin binding protein 1
Image
GO Annotations	Cellular Component	Stress Fiber Extracellular Space Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Actin Filament Site Of Polarized Growth Cortical Actin Cytoskeleton Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity Myosin Binding ADP Binding	Actin Binding Protein Binding Enzyme Binding Actin Filament Binding
	Biological Process	Muscle Contraction Positive Regulation Of Gene Expression Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Development Mesenchyme Migration	Regulation Of Actin Filament Polymerization Defense Response To Fungus
Pathways		Striated Muscle Contraction Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Neutrophil degranulation
Drugs		Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases		Cap myopathy Congenital fiber type disproportion (CFTD) Nemaline myopathy
GWAS			Carotid intima media thickness x smoking interaction ( 32117412) Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) ( 29535761) Cocaine dependence ( 31212010) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Heel bone mineral density ( 30598549) Macular thickness ( 30535121)
Interacting Genes		115 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 LINC00624 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	6 interacting genes: ACTA1 ACTB ACTG1 ALOX5 PDE6H TERF2IP
Entrez ID		58	23406
HPRD ID		00030	09482
Ensembl ID		ENSG00000143632	ENSG00000103187
Uniprot IDs		P68133	A0A384MTY2 Q14019
PDB IDs		7RNS 7RNU 7RNV 9DUU 9DUV	1T2L 1T3X 1T3Y 1TMW 1VFQ 1WNJ
Enriched GO Terms of Interacting Partners?		Actin Binding Actin Filament Binding Cytoskeleton Actin Cytoskeleton Actin Filament-based Process Cytoplasm Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Actin Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytosol Regulation Of Cellular Component Size Regulation Of Protein-containing Complex Assembly Cell Cortex Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Lamellipodium Ruffle Actin Filament Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Cortical Actin Cytoskeleton Positive Regulation Of Cellular Component Biogenesis Actin Polymerization Or Depolymerization Regulation Of Biological Quality Anchoring Junction Organelle Organization Ruffle Membrane Positive Regulation Of Protein-containing Complex Assembly Cell Projection Filopodium Regulation Of Cell Shape Muscle System Process Negative Regulation Of Actin Filament Depolymerization Regulation Of Protein Localization	Regulation Of Transepithelial Transport Dense Body Morphogenesis Of A Polarized Epithelium Structural Constituent Of Postsynaptic Actin Cytoskeleton Actin Filament Structural Constituent Of Cytoskeleton Blood Microparticle Postsynaptic Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Postsynaptic Cytoskeleton Organization Regulation Of Synaptic Vesicle Endocytosis NuA4 Histone Acetyltransferase Complex Apical Junction Complex Regulation Of Synaptic Vesicle Recycling Maintenance Of Blood-brain Barrier Hydrolase Activity Actin Cytoskeleton Platelet Aggregation Morphogenesis Of An Epithelium Homotypic Cell-cell Adhesion Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Tissue Morphogenesis Protein Localization To Cell Junction Regulation Of Double-strand Break Repair Via Homologous Recombination Schaffer Collateral - CA1 Synapse Regulation Of Norepinephrine Uptake Leukotriene A4 Metabolic Process Leukotriene Production Involved In Inflammatory Response Arachidonate 8(S)-lipoxygenase Activity Negative Regulation Of DNA Recombination At Telomere Regulation Of Cellular Response To Stress Cell-cell Junction Assembly Nuclear Matrix Transporter Regulator Activity Lipoxin Biosynthetic Process Arachidonate 12(S)-lipoxygenase Activity Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Regulation Of DNA Recombination Regulation Of Wound Healing Cytoskeleton Extracellular Space Regulation Of Double-strand Break Repair Arachidonate Metabolite Production Involved In Inflammatory Response Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Axonogenesis
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