ACTA1 and AIF1

Number of citations of the paper that reports this interaction (PubMedID 12714565)
0

Data Source:
HPRD (in vitro, in vivo)

		ACTA1	AIF1
Description		actin alpha 1, skeletal muscle	allograft inflammatory factor 1
Image
GO Annotations	Cellular Component	Stress Fiber Extracellular Space Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle	Ruffle Phagocytic Cup Nucleus Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Membrane Lamellipodium Ruffle Membrane Cell Projection Perinuclear Region Of Cytoplasm Glial Cell Projection
	Molecular Function	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity Myosin Binding ADP Binding	Actin Binding Calcium Ion Binding Protein Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Muscle Contraction Positive Regulation Of Gene Expression Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Development Mesenchyme Migration	Microglial Cell Activation Phagocytosis, Engulfment Inflammatory Response Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Rac Protein Signal Transduction Actin Filament Polymerization Parallel Actin Filament Bundle Assembly Positive Regulation Of Cell Migration Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Cellular Response To Oxidative Stress Positive Regulation Of T Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Chemotaxis Actin Filament Bundle Assembly Actin Crosslink Formation Cellular Response To Type II Interferon Negative Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Fibroblast Growth Factor Production Ruffle Assembly Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of T Cell Migration
Pathways		Striated Muscle Contraction Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases		Cap myopathy Congenital fiber type disproportion (CFTD) Nemaline myopathy
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Appendicular lean mass ( 33097823) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 22936669) Heel bone mineral density ( 30598549) Height ( 23563607) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Laryngeal squamous cell carcinoma ( 25194280) Malaria ( 31844061) Mean platelet volume ( 32888494) Neonatal lupus ( 20662065) Oral cavity cancer ( 27749845) Platelet count ( 32888494) Rosacea symptom severity ( 29771307) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Takayasu arteritis ( 25604533) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Weight ( 19079260)
Interacting Genes		115 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 LINC00624 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	2 interacting genes: ACTA1 LCP1
Entrez ID		58	199
HPRD ID		00030	03496
Ensembl ID		ENSG00000143632	ENSG00000204472
Uniprot IDs		P68133	I3WTX1 P55008 Q4V347
PDB IDs		7RNS 7RNU 7RNV 9DUU 9DUV	2D58 2G2B
Enriched GO Terms of Interacting Partners?		Actin Binding Actin Filament Binding Cytoskeleton Actin Cytoskeleton Actin Filament-based Process Cytoplasm Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Actin Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytosol Regulation Of Cellular Component Size Regulation Of Protein-containing Complex Assembly Cell Cortex Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Lamellipodium Ruffle Actin Filament Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Cortical Actin Cytoskeleton Positive Regulation Of Cellular Component Biogenesis Actin Polymerization Or Depolymerization Regulation Of Biological Quality Anchoring Junction Organelle Organization Ruffle Membrane Positive Regulation Of Protein-containing Complex Assembly Cell Projection Filopodium Regulation Of Cell Shape Muscle System Process Negative Regulation Of Actin Filament Depolymerization Regulation Of Protein Localization	Actin Filament Filopodium Stress Fiber Actin Filament Organization Actin Cytoskeleton Supramolecular Fiber Organization Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Actin Filament Network Formation Striated Muscle Thin Filament Actin Filament Bundle Positive Regulation Of Podosome Assembly Protein Kinase A Signaling Regulation Of Podosome Assembly Actin Crosslink Formation Skeletal Muscle Fiber Development Myosin Binding Cortical Actin Cytoskeleton Organization Wound Healing, Spreading Of Cells Phagocytic Cup Glial Cell Projection Myotube Cell Development ADP Binding GTPase Binding Podosome Cortical Cytoskeleton Organization Extracellular Matrix Disassembly Sarcomere Animal Organ Regeneration Cytoskeleton Extracellular Space Actin Filament Bundle Assembly Actin Filament Bundle Organization Striated Muscle Cell Development T Cell Activation Involved In Immune Response Cell Body Structural Constituent Of Cytoskeleton Muscle Cell Development Ruffle Membrane Positive Regulation Of Organelle Assembly Ruffle Extracellular Exosome Blood Microparticle Lymphocyte Activation Involved In Immune Response Regeneration Regulation Of Intracellular Protein Transport Integrin Binding Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response
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