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HTRA2 and AREL1
Number of citations of the paper that reports this interaction (PubMedID
23479728
)
30
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study)
HTRA2
AREL1
Description
HtrA serine peptidase 2
apoptosis resistant E3 ubiquitin protein ligase 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Mitochondrion
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Cytoskeleton
Cytoplasmic Side Of Plasma Membrane
Membrane
Mitochondrial Membrane
Protein-containing Complex
CD40 Receptor Complex
Serine-type Endopeptidase Complex
Cytoplasm
Cytosol
Molecular Function
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Hydrolase Activity
Protein Serine/threonine Kinase Inhibitor Activity
Identical Protein Binding
Unfolded Protein Binding
Ubiquitin Ligase Inhibitor Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Transferase Activity
Ubiquitin Protein Ligase Activity
Biological Process
Proteolysis
Ceramide Metabolic Process
Apoptotic Process
Mitochondrion Organization
Adult Walking Behavior
Adult Locomotory Behavior
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Herbicide
Programmed Cell Death
Protein Autoprocessing
Pentacyclic Triterpenoid Metabolic Process
Protein Catabolic Process
Forebrain Development
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To Interferon-beta
Intracellular Signal Transduction
Mitochondrial Protein Catabolic Process
Regulation Of Multicellular Organism Growth
Positive Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Cell Cycle
Neuron Development
Neuron Apoptotic Process
Cellular Response To Retinoic Acid
Cellular Response To Growth Factor Stimulus
Intrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Positive Regulation Of Execution Phase Of Apoptosis
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Type 2 Mitophagy
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Protein Ubiquitination
Negative Regulation Of Apoptotic Process
Regulation Of Inflammatory Response
Protein K11-linked Ubiquitination
Protein K33-linked Ubiquitination
Pathways
Mitochondrial protein degradation
Mitochondrial unfolded protein response (UPRmt)
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Parkinson's disease (PD)
GWAS
General factor of neuroticism (
30867560
)
Glaucoma (primary open-angle) (
33627673
)
Mood instability (
29187730
)
Interacting Genes
41 interacting genes:
ACTA1
ALDH1A2
APC
APP
AREL1
BIRC2
BIRC3
BIRC6
BIRC7
CAD
CCAR2
CDK1
CDK5
CSN1S1
CSN2
DIABLO
EEF1A1
EIF4G1
HSD17B10
IMMT
ITGA7
MAPK11
MAPK12
MAPK13
MAPK14
MAPK3
MUL1
PAG1
PDXDC1
PDXDC2P-NPIPB14P
PEA15
TRIM28
TUBA1A
TUBB
TUBB6
TUBB7P
UBC
USP7
VIM
VPS4B
XIAP
10 interacting genes:
CRKL
DIABLO
HTRA2
PIAS4
SEPTIN4
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2L3
Entrez ID
27429
9870
HPRD ID
05919
13794
Ensembl ID
ENSG00000115317
ENSG00000119682
Uniprot IDs
A0A384MDW9
A0A8Q3SIX7
O43464
A0A7P0T811
O15033
PDB IDs
1LCY
2PZD
5FHT
5M3N
5M3O
5TNY
5TNZ
5TO0
5TO1
5WYN
7VGE
8AUK
8E2K
6JX5
6LOH
Enriched GO Terms of Interacting Partners
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Cell Death
Apoptotic Process
Programmed Cell Death
MAP Kinase Activity
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
MAPK Cascade
Regulation Of Cell Cycle
Ubiquitin-protein Transferase Activity
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Transferase Activity
Cysteine-type Endopeptidase Inhibitor Activity
Cytosol
Intracellular Signal Transduction
Ubiquitin Protein Ligase Activity
Protein Kinase Activity
Regulation Of Apoptotic Process
Intracellular Signaling Cassette
Structural Constituent Of Cytoskeleton
Regulation Of Programmed Cell Death
Response To Cytokine
Response To Peptide
Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Regulation Of Inflammatory Response
Acetylcholine Receptor Activator Activity
Cytoplasm
Response To Light Stimulus
Positive Regulation Of Post-translational Protein Modification
Glial Cell Development
Protein Serine Kinase Activity
Post-translational Protein Modification
Regulation Of Post-translational Protein Modification
Nucleotide Binding
P38MAPK Cascade
Protein Modification By Small Protein Conjugation
Regulation Of Protein Metabolic Process
Regulation Of Intracellular Transport
Protein Serine/threonine Kinase Activity
Protein Metabolic Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Growth
Regulation Of Synapse Organization
Response To Radiation
DNA Damage Response
Protein Ubiquitination
Regulation Of Protein Ubiquitination
Regulation Of Developmental Growth
Regulation Of Toll-like Receptor Signaling Pathway
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Protein Modification Process
Ubiquitin Conjugating Enzyme Activity
Positive Regulation Of Post-translational Protein Modification
Positive Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Establishment Of Protein Localization To Mitochondrion
Protein Modification By Small Protein Conjugation
Regulation Of Protein Targeting To Mitochondrion
Post-translational Protein Modification
Regulation Of Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Modification-dependent Protein Catabolic Process
CD40 Receptor Complex
Macromolecule Catabolic Process
Protein Polyubiquitination
Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Protein K48-linked Ubiquitination
Proteolysis Involved In Protein Catabolic Process
Proteolysis
Ubiquitin Protein Ligase Activity
Positive Regulation Of Protein Modification Process
Positive Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Signal Transduction
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Apoptotic Process
Cell Death
Negative Regulation Of Cell Communication
Regulation Of Protein Localization
Programmed Cell Death
Negative Regulation Of Signaling
Regulation Of Intrinsic Apoptotic Signaling Pathway
Cytosol
Regulation Of Protein Ubiquitination
Protein K11-linked Ubiquitination
Positive Regulation Of Apoptotic Process
Protein Modification Process
Positive Regulation Of Programmed Cell Death
Ubiquitin-dependent Protein Catabolic Process
Pentacyclic Triterpenoid Metabolic Process
Regulation Of Protein Modification Process
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Catabolic Process
Ubiquitin Protein Ligase Binding
Protein Autoubiquitination
Positive Regulation Of Establishment Of Protein Localization
Helper T Cell Diapedesis
Mitochondrial Intermembrane Space
Negative Regulation Of Type 2 Mitophagy
Limb Epidermis Development
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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